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ABCC2

Michael — Wed, 08 Jul 2026 17:28:28 GMT

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	*Brush border staining suggests response to immunotherapy.<ref>{{cite journal \|authors=Castillo VF, Zakhary A, Rotondo F, Di Ciano-Oliveira C, Hamdani M, Adona E, van der Kwast T, Trpkov K, Saleeb R \|title=Papillary renal cell carcinoma with high-ABCC2 shows an immune-evasive profile associated with favorable response to immunotherapy \|journal=J Pathol \|volume=268 \|issue=2 \|pages=188–199 \|date=February 2026 \|pmid=41259021 \|doi=10.1002/path.70001 \|url=}}</ref>		*Brush border staining suggests response to immunotherapy.<ref>{{cite journal \|authors=Castillo VF, Zakhary A, Rotondo F, Di Ciano-Oliveira C, Hamdani M, Adona E, van der Kwast T, Trpkov K, Saleeb R \|title=Papillary renal cell carcinoma with high-ABCC2 shows an immune-evasive profile associated with favorable response to immunotherapy \|journal=J Pathol \|volume=268 \|issue=2 \|pages=188–199 \|date=February 2026 \|pmid=41259021 \|doi=10.1002/path.70001 \|url=}}</ref>

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			===Positive===
			<pre>
			ABCC2 brush border staining in the tumour is PRESENT, patchy and estimated as >50%; the presence of significant ABCC2 staining suggests a more aggressive disease.[1]

			The findings are in keeping with papillary renal cell carcinoma; the diagnosis is not changed.

			1. Histopathology. 2023 Dec;83(6):949-958. doi: 10.1111/his.15042.
			</pre>

			===Negative===
			<pre>
			Significant ABCC2 brush border staining in the tumour is ABSENT (<50%).
			</pre>

	==References==		==References==