View source for MAP2

'''MICROTUBULE-ASSOCIATED PROTEIN 2''', abbreviated '''MAP2''',<ref>{{OMIM|157130}}</ref> is a common [[immunostain]] used in [[neuropathology]] and [[pulmonary]] pathology. It's expression is associated with neuronal, glial or neuroendocrine differentiation

==Positive==
*CNS cortex, esp. [[Neurohistology#Neuron|neuron]]s. <ref name="pmid7479905"> {{Cite journal  | last1 = Kalcheva | first1 = N. | last2 = Albala | first2 = J. | last3 = O'Guin | first3 = K. | last4 = Rubino | first4 = H. | last5 = Garner | first5 = C. | last6 = Shafit-Zagardo | first6 = B. | title = Genomic structure of human microtubule-associated protein 2 (MAP-2) and characterization of additional MAP-2 isoforms. | journal = Proc Natl Acad Sci U S A | volume = 92 | issue = 24 | pages = 10894-8 | month = Nov | year = 1995 | doi =  | PMID = 7479905 }}</ref>
* [[Oligodendroglioma]], predominantly perinuclear <ref name="pmid11589429">{{Cite journal  | last1 = Blümcke | first1 = I. | last2 = Becker | first2 = AJ. | last3 = Normann | first3 = S. | last4 = Hans | first4 = V. | last5 = Riederer | first5 = BM. | last6 = Krajewski | first6 = S. | last7 = Wiestler | first7 = OD. | last8 = Reifenberger | first8 = G. | title = Distinct expression pattern of microtubule-associated protein-2 in human oligodendrogliomas and glial precursor cells. | journal = J Neuropathol Exp Neurol | volume = 60 | issue = 10 | pages = 984-93 | month = Oct | year = 2001 | doi =  | PMID = 11589429 }}</ref>
* [[Ganglioglioma]] <ref name="pmid11869037">{{Cite journal  | last1 = Duggal | first1 = N. | last2 = Hammond | first2 = RR. | title = Nestin expression in ganglioglioma. | journal = Exp Neurol | volume = 174 | issue = 1 | pages = 89-95 | month = Mar | year = 2002 | doi = 10.1006/exnr.2001.7838 | PMID = 11869037 }}</ref>
* [[Astrocytoma]] / [[Glioblastoma]] <ref name="pmid11922706">{{Cite journal  | last1 = Wharton | first1 = SB. | last2 = Chan | first2 = KK. | last3 = Whittle | first3 = IR. | title = Microtubule-associated protein 2 (MAP-2) is expressed in low and high grade diffuse astrocytomas. | journal = J Clin Neurosci | volume = 9 | issue = 2 | pages = 165-9 | month = Mar | year = 2002 | doi = 10.1054/jocn.2001.1055 | PMID = 11922706 }}</ref>
* [[Neurocytoma]] / [[Medulloblastoma]] <ref name="pmid12605092">{{Cite journal  | last1 = Liu | first1 = Y. | last2 = Saad | first2 = RS. | last3 = Shen | first3 = SS. | last4 = Silverman | first4 = JF. | title = Diagnostic value of microtubule-associated protein-2 (MAP-2) for neuroendocrine neoplasms. | journal = Adv Anat Pathol | volume = 10 | issue = 2 | pages = 101-6 | month = Mar | year = 2003 | doi =  | PMID = 12605092 }}</ref>
* [[Dysembryoplastic neuroepithelial tumour]] <ref name="pmid12670051">{{Cite journal  | last1 = Duggal | first1 = N. | last2 = Iskander | first2 = S. | last3 = Hammond | first3 = RR. | title = MAP2 and nestin co-expression in dysembryoplastic neuroepithelial tumors. | journal = Clin Neuropathol | volume = 22 | issue = 2 | pages = 57-65 | month =  | year =  | doi =  | PMID = 12670051 }}</ref>
* [[Small cell lung carcinoma]] <ref name="pmid24004589">{{Cite journal  | last1 = Zhou | first1 = DM. | last2 = Sun | first2 = Y. | last3 = Li | first3 = XH. | title = [Diagnostic value of microtubule-associated protein-2 in small cell lung carcinoma: an analysis of 240 biopsy cases]. | journal = Zhonghua Bing Li Xue Za Zhi | volume = 42 | issue = 5 | pages = 321-4 | month = May | year = 2013 | doi =  | PMID = 24004589 }}</ref>
* [[Carcinoid tumour]] <ref name="pmid11557784>{{Cite journal  | last1 = Liu | first1 = Y. | last2 = Sturgis | first2 = CD. | last3 = Grzybicki | first3 = DM. | last4 = Jasnosz | first4 = KM. | last5 = Olson | first5 = PR. | last6 = Tong | first6 = M. | last7 = Dabbs | first7 = DD. | last8 = Raab | first8 = SS. | last9 = Silverman | first9 = JF. | title = Microtubule-associated protein-2: a new sensitive and specific marker for pulmonary carcinoid tumor and small cell carcinoma. | journal = Mod Pathol | volume = 14 | issue = 9 | pages = 880-5 | month = Sep | year = 2001 | doi = 10.1038/modpathol.3880406 | PMID = 11557784 }}</ref>
* [[Merkel cell carcinoma]] <ref name="pmid14663358"> {{Cite journal  | last1 = Liu | first1 = Y. | last2 = Mangini | first2 = J. | last3 = Saad | first3 = R. | last4 = Silverman | first4 = AR. | last5 = Abell | first5 = E. | last6 = Tung | first6 = MY. | last7 = Graner | first7 = SR. | last8 = Silverman | first8 = JF. | title = Diagnostic value of microtubule-associated protein-2 in Merkel cell carcinoma. | journal = Appl Immunohistochem Mol Morphol | volume = 11 | issue = 4 | pages = 326-9 | month = Dec | year = 2003 | doi =  | PMID = 14663358 }}</ref>

===Images===
<gallery>
File:MAP2 anaplastic oligodendroglioma.jpg | Perinuclear MAP2 in [[Oligodendroglioma]]
File:Medulloblastoma MAP2 IHC.jpg | MAP2 in [[Medulloblastoma]]
File:DNET MAP-high power.jpg | MAP2 in floating neurons of [[DNT]]
File:Neuropathology case II 07.jpg | MAP2 in [[astrocytoma]]
</gallery>

==See also==
*[[Immunohistochemistry]].

==References==
{{Reflist|1}}

[[Category:Immunohistochemistry]]
[[Category:Neuropathology]]