Atypical lobular hyperplasia - Revision history

Michael at 05:14, 23 January 2017

2017-01-23T05:14:24Z

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	\| Caption = Atypical lobular hyperplasia. [[H&E stain]]. (WC/Nephron)		\| Caption = Atypical lobular hyperplasia. [[H&E stain]]. (WC/Nephron)
	\| Synonyms =		\| Synonyms =
	\| Micro = morphologic changes ('''a'''typia minimal - usually, '''b'''orders of cells distinct/visible - ''dyscohesive'', '''c'''lear cytoplasm (focal), '''d'''istend duct, '''e'''ccentric nucleus, usu. round, '''f'''illed ducts ('''no''' luminal spaces - '''key feature'''), limited extent (<50% of terminal duct lobular unit ~~(TDLU)~~ is involved)		\| Micro = morphologic changes ('''a'''typia minimal - usually, '''b'''orders of cells distinct/visible - ''dyscohesive'', '''c'''lear cytoplasm (focal), '''d'''istend duct, '''e'''ccentric nucleus, usu. round, '''f'''illed ducts ('''no''' luminal spaces - '''key feature'''), limited extent (<50% of terminal duct lobular unit is involved)
	\| Subtypes =		\| Subtypes =
	\| LMDDx = [[lobular carcinoma in situ]], [[lobular carcinoma]]		\| LMDDx = [[lobular carcinoma in situ]], [[lobular carcinoma]]

2017-01-23T05:10:07Z

← Older revision		Revision as of 05:10, 23 January 2017
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	\| Caption = Atypical lobular hyperplasia. [[H&E stain]]. (WC/Nephron)		\| Caption = Atypical lobular hyperplasia. [[H&E stain]]. (WC/Nephron)
	\| Synonyms =		\| Synonyms =
	\| Micro =		\| Micro = morphologic changes ('''a'''typia minimal - usually, '''b'''orders of cells distinct/visible - ''dyscohesive'', '''c'''lear cytoplasm (focal), '''d'''istend duct, '''e'''ccentric nucleus, usu. round, '''f'''illed ducts ('''no''' luminal spaces - '''key feature'''), limited extent (<50% of terminal duct lobular unit (TDLU) is involved)
	\| Subtypes =		\| Subtypes =
	\| LMDDx = [[lobular carcinoma in situ]], [[lobular carcinoma]]		\| LMDDx = [[lobular carcinoma in situ]], [[lobular carcinoma]]

2017-01-23T05:05:01Z

Microscopic

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	==Microscopic==		==Microscopic==
	Features:		Features:
	*~~Extent criterium~~: <50% of terminal duct lobular unit (TDLU) is involved.		#Morphologic changes - memory device ''ABCDEF'':
	*See ''[[lobular carcinoma in situ]]'' for details.		#*'''A'''typia minimal - usually.
			#**Relatively small ~1-2x size lymphocyte.
			#*'''B'''orders of cells distinct/visible - ''dyscohesive''.
			#*'''C'''lear cytoplasm (focal).
			#**May have a signet ring cell-like appearance.
			#*'''D'''istend duct.
			#*'''E'''ccentric nucleus, usu. round.
			#*'''F'''illed ducts.
			#**'''No''' luminal spaces - '''key feature'''.
			#***Partially filled ducts are ''not'' LCIS.
			#Limited extent: <50% of terminal duct lobular unit (TDLU) is involved.

	DDx:		DDx:

2017-01-23T04:58:59Z

tweak

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			{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image = Atypical lobular hyperplasia -- high mag.jpg
			\| Width =
			\| Caption = Atypical lobular hyperplasia. [[H&E stain]]. (WC/Nephron)
			\| Synonyms =
			\| Micro =
			\| Subtypes =
			\| LMDDx = [[lobular carcinoma in situ]], [[lobular carcinoma]]
			\| Stains =
			\| IHC = E-cadherin -ve
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross =
			\| Grossing =
			\| Staging =
			\| Site = [[breast]]
			\| Assdx =
			\| Syndromes =
			\| Clinicalhx =
			\| Signs =
			\| Symptoms =
			\| Prevalence =
			\| Bloodwork =
			\| Rads =
			\| Endoscopy =
			\| Prognosis = benign
			\| Other =
			\| ClinDDx =
			\| Tx =
			}}
	'''Atypical lobular hyperplasia''', abbreviated '''ALH''', a pre-malignant change in the [[breast]] characterized by cellular proliferation and cellular dyscohesion.		'''Atypical lobular hyperplasia''', abbreviated '''ALH''', a pre-malignant change in the [[breast]] characterized by cellular proliferation and cellular dyscohesion.

2017-01-23T04:53:59Z

+images

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	*[[Lobular carcinoma in situ]].		*[[Lobular carcinoma in situ]].
	*[[Lobular carcinoma]].		*[[Lobular carcinoma]].

			===Images===
			<gallery>
			Image: Atypical lobular hyperplasia -- low mag.jpg \| ALH - low mag. (WC)
			Image: Atypical lobular hyperplasia -- intermed mag.jpg \| ALH - intermed. mag. (WC)
			Image: Atypical lobular hyperplasia -- high mag.jpg \| ALH - high mag. (WC)

			Image: Atypical lobular hyperplasia - E-cadherin -- intermed mag.jpg \| ALH - E-cadherin - intermed. mag. (WC)
			Image: Atypical lobular hyperplasia - E-cadherin -- high mag.jpg \| ALH - E-cadherin - high mag. (WC)
			</gallery>
			<gallery>
			Image: Benign breast - E-cadherin -- intermed mag.jpg \| Benign breast - E-cadherin - intermed. mag. (WC)
			Image: Benign breast - E-cadherin -- high mag.jpg \| Benign breast - E-cadherin - high mag. (WC)
			Image: Benign breast - E-cadherin - alt -- high mag.jpg \| Benign breast - E-cadherin - high mag. (WC)
			</gallery>

	==IHC==		==IHC==

2016-11-28T22:03:50Z

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	'''Atypical lobular hyperplasia''', abbreviated '''ALH''', a pre-malignant change in the [[breast]] characterized cellular proliferation and cellular dyscohesion.		'''Atypical lobular hyperplasia''', abbreviated '''ALH''', a pre-malignant change in the [[breast]] characterized by cellular proliferation and cellular dyscohesion.

	It can be seen as the precursor to [[lobular carcinoma in situ]], the precursor of [[lobular carcinoma]].		It can be seen as the precursor to [[lobular carcinoma in situ]], the precursor of [[lobular carcinoma]].

2016-11-28T05:46:55Z

← Older revision		Revision as of 05:46, 28 November 2016
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	'''Atypical lobular hyperplasia''', abbreviated '''ALH''', a pre-malignant change in the breast characterized cellular proliferation and cellular dyscohesion.		'''Atypical lobular hyperplasia''', abbreviated '''ALH''', a pre-malignant change in the [[breast]] characterized cellular proliferation and cellular dyscohesion.

	It can be seen as the ~~pre-cursor~~ to ~~the pre-cursor (~~[[lobular carcinoma in situ]]).		It can be seen as the precursor to [[lobular carcinoma in situ]], the precursor of [[lobular carcinoma]].

	==General==		==General==

2016-11-28T05:44:35Z

split out

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	~~#redirect~~ [[Non-~~invasive_breast_carcinoma#Atypical_lobular_hyperplasia~~]]		'''Atypical lobular hyperplasia''', abbreviated '''ALH''', a pre-malignant change in the breast characterized cellular proliferation and cellular dyscohesion.

			It can be seen as the pre-cursor to the pre-cursor ([[lobular carcinoma in situ]]).

			==General==
			*May occur with ''ductal involvement by cells of atypical lobular hyperplasia'' (abbreviated ''DIALH'').<ref name=pmid3343034>{{Cite journal \| last1 = Page \| first1 = DL. \| last2 = Dupont \| first2 = WD. \| last3 = Rogers \| first3 = LW. \| title = Ductal involvement by cells of atypical lobular hyperplasia in the breast: a long-term follow-up study of cancer risk. \| journal = Hum Pathol \| volume = 19 \| issue = 2 \| pages = 201-7 \| month = Feb \| year = 1988 \| doi = \| PMID = 3343034 }}</ref>
			**ALH with DIALH has a risk of developing breast cancer that is similar to [[LCIS]].

			==Microscopic==
			Features:
			*Extent criterium: <50% of terminal duct lobular unit (TDLU) is involved.
			*See ''[[lobular carcinoma in situ]]'' for details.

			DDx:
			*[[Lobular carcinoma in situ]].
			*[[Lobular carcinoma]].

			==IHC==
			*E-cadherin -ve ''or'' incomplete membrane staining.

			==See also==
			*[[Non-invasive breast carcinoma]].

			==References==
			{{Reflist\|1}}

	[[Category:Diagnosis]]		[[Category:Diagnosis]]
			[[Category:Breast pathology]]

2011-12-10T06:28:07Z

create

New page

#redirect [[Non-invasive_breast_carcinoma#Atypical_lobular_hyperplasia]]

[[Category:Diagnosis]]