Case 111 - Revision history

Michael: /* Other cases */

2015-09-27T02:45:31Z

Other cases

← Older revision		Revision as of 02:45, 27 September 2015
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	[[Category:Cases]]		[[Category:Cases]]

	[[Category:Cases in ~~gynecological~~ pathology]]		[[Category:Cases in gynecologic pathology]]
	[[Category:Cases in ~~gynecological~~ pathology - junior]]		[[Category:Cases in gynecologic pathology - junior]]

	[[Category:Cases difficulty 2]] <!-- difficulty 1-7 -- should roughly correspond to the PGY level -->		[[Category:Cases difficulty 2]] <!-- difficulty 1-7 -- should roughly correspond to the PGY level -->

Michael at 02:43, 27 September 2015

2015-09-27T02:43:19Z

← Older revision		Revision as of 02:43, 27 September 2015
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	===Provided clinical history===		===Provided clinical history===
	28 year old woman with a positive pregnancy test. Cornual mass on ultrasound. No fetal heart identified.		28 year old woman with a positive pregnancy test. Cornual mass on ultrasound. No fetal heart identified.

	===Site===		===Site===
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	{{hidden\|Intermediate magnification\|[[Image: Ariasstella changes in endometrium 20x.jpg \|500px\|link=\|center\|]]		{{hidden\|Intermediate magnification\|[[Image: Ariasstella changes in endometrium 20x.jpg \|500px\|link=\|center\|]]
	<center>Intermediate magnification. [[H&E stain]].</center>}}		<center>Intermediate magnification. [[H&E stain]].</center>}}

	~~{{hidden\|High magnification\|[[Image: NAME OF IMAGE GOES HERE \|500px\|link=\|center\|]]~~
	~~<center>High magnification. [[H&E stain]].</center>}}~~

	===Differential diagnosis===		===Differential diagnosis===
	{{hidden\|Differential diagnosis\|<center>~~CLEAR CELL CARCINOMA~~</center>}}		{{hidden\|Differential diagnosis\|<center>[[clear cell carcinoma]]</center>}}

	===Additional tests===		===Additional tests===
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	===Diagnosis===		===Diagnosis===
	{{hidden\|Diagnosis\|<center>ARIAS STELLA CHANGES/REACTION. The diagnosis in this case is straightforward and relatively easy in this very young patient with a positive pregnancy test. However, it can be challenging in an older patient who comes in with bleeding. Arias Stella reaction shows endometrial glands lined by clear cells with atypia. Intranuclear inclusions (arrow) are often present. There can be occasional mitotic activity, which can further heighten its mimicry to clear cell carcinoma. Furthermore, the clear cells of Arias Stella are positive for Napsin and HNF1Beta, markers that are positive in clear cell carcinoma. AMACR is reportedly negative in Arias Stella while being positive in clear cell carcinoma although too few cases are tested to be confident of this claim. ~~</center>~~}}		{{hidden\|Diagnosis\|<center>ARIAS STELLA CHANGES/REACTION</center>
			<br>
			The diagnosis in this case is straightforward and relatively easy in this very young patient with a positive [[pregnancy]] test. However, it can be challenging in an older patient who comes in with bleeding. Arias Stella reaction shows endometrial glands lined by clear cells with atypia. Intranuclear inclusions (arrow) are often present. There can be occasional mitotic activity, which can further heighten its mimicry to [[clear cell carcinoma]]. Furthermore, the clear cells of Arias Stella are positive for Napsin and HNF1Beta, markers that are positive in clear cell carcinoma. [[AMACR]] is reportedly negative in Arias Stella while being positive in clear cell carcinoma although too few cases are tested to be confident of this claim.}}
	<br>		<br>
	===Other cases===		===Other cases===
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	[[Category:Cases]]		[[Category:Cases]]

	~~<!-- SELECT A CATEGORY~~
	[[Category:Cases in gynecological pathology]]		[[Category:Cases in gynecological pathology]]
	-->		[[Category:Cases in gynecological pathology - junior]]

	[[Category:Cases difficulty 2]] <!-- difficulty 1-7 -- should roughly correspond to the PGY level -->		[[Category:Cases difficulty 2]] <!-- difficulty 1-7 -- should roughly correspond to the PGY level -->

Rudolf: Rudolf moved page Case111 to Case 111

2015-09-24T18:15:50Z

Rudolf moved page Case111 to Case 111

← Older revision

Revision as of 18:15, 24 September 2015

Vinita: Created page with "===Provided clinical history=== 28 year old woman with a positive pregnancy test. Cornual mass on ultrasound. No fetal heart identified. ===Site=== Pregnancy ===Primary im..."

2015-09-24T16:41:00Z

Created page with "===Provided clinical history=== 28 year old woman with a positive pregnancy test. Cornual mass on ultrasound. No fetal heart identified. ===Site=== Pregnancy ===Primary im..."

New page

===Provided clinical history===
28 year old woman with a positive pregnancy test. Cornual mass on ultrasound. No fetal heart identified.

===Site===
Pregnancy

===Primary image===
[[Image: Ariasstella changes in endometrium 4x.jpg |500px|link=|center|]]
<center>Low magnification. [[H&E stain]].</center>

{{hidden|Intermediate magnification|[[Image: Ariasstella changes in endometrium 20x.jpg |500px|link=|center|]]
<center>Intermediate magnification. [[H&E stain]].</center>}}

{{hidden|High magnification|[[Image: NAME OF IMAGE GOES HERE |500px|link=|center|]]
<center>High magnification. [[H&E stain]].</center>}}

===Differential diagnosis===
{{hidden|Differential diagnosis|<center>CLEAR CELL CARCINOMA</center>}}

===Additional tests===
====More history====
{{hidden|More history|<center>MORE HISTORY HERE</center>}}

====Ask a colleague====
{{hidden|Ask a colleague|<center>COLLEAGUE'S ADVICE HERE</center>}}

====Stains====
{{Case Stains
| blank=Dr Torres would ask why!
| alcpas=
| alc1=
| alc25=
| aur=
| biel=
| bili=
| iron=
| congored=
| cresylv=
| dieterle=
| diffquik=
| fontana=
| gallyas=
| giemsa=
| gms=
| gomori=
| gram=
| gremelius=
| jms=
| jones=
| kinyoun=
| luxol=
| masson=
| mmas=
| movat=
| mucicar=
| oilredo=
| orecein=
| pas=
| pasd=
| pasf=
| ptah=
| prussian=
| reticulin=
| sudanblackb=
| toluidine=
| verhoeff=
| vonkossa=
| warthinstarry=
| zn=
}}
====IHC====
{{Case IHC
| blank=Dr Torres would ask why!
| a1at=
| acth=
| ae1ae3=
| afp=
| alk1=
| amacr=
| ar=
| atrx=
| b2microglobulin=
| b72_3=
| bcatenin=
| bcl2=
| bcl6=
| bclxl=
| c3=
| ca9=
| calcitonin=
| calponin=
| calretinin=
| cam5p2=
| cathepsink=
| cd10=
| cd117=
| cd138=
| cd15=
| cd1a=
| cd20=
| cd21=
| cd23=
| cd3=
| cd30=
| cd31=
| cd34=
| cd35=
| cd4=
| cd43=
| cd45=
| cd5=
| cd56=
| cd57=
| cd68=
| cd7=
| cd79a=
| cd8=
| cd99=
| cdx2=
| cea=
| chromo=
| ck17=
| ck19=
| ck20=
| ck34be12=
| ck5_6=
| ck7=
| cmv=
| cmyc=
| cyclin_d1=
| d2_40=
| desmin=
| dog1=
| ebv=
| ema=
| erpr=
| f_viii=
| f_xiiia=
| fascin=
| fh=
| fsh=
| gastrin=
| gata3=
| gcdfp=
| gfap=
| gh=
| glucagon=
| glypican3=
| hbme1=
| hbv_core=
| hbv_surf=
| hcaldesmon=
| hcg=
| helicobacter=
| hepatocyte=
| her2=
| hhv8=
| hmb45=
| hnf1beta= POSITIVE
| hpv=
| hsv1=
| hsv2=
| Idh-1=
| inhibin=
| ini1=
| insulin=
| kappa=
| ki67=
| lambda=
| leu7=
| lga=
| lgg=
| lgm=
| lh=
| lysozyme=
| mammogl=
| map2=
| mcv=
| melanin_a=
| mitf=
| mum1=
| myleoperox=
| myo_d1=
| myog=
| nf=
| nkx3_1=
| nse=
| oct3_4=
| p16=
| p501s=
| p53=
| p57=
| p63=
| panker=
| pax2=
| pax5=
| pax8=
| pcna=
| pdgfr=
| plap=
| pnl-2c=
| prolactin=
| psa=
| psap=
| rcc=
| s100=
| sma=
| somatsatin=
| synapto=
| tdt=
| tfe3=
| tfeb=
| thyrogl=
| toxopl=
| tsh=
| ttf1=
| ubiquitin=
| uchl1=
| ulex_europe=
| vim=
| vip=
| vzv=
| wt1=
}}

====Molecular testing====
=====Chromosomal translocations=====
{{Case Translocations
| blank=Dr Torres would ask why!
| t1_13=
| t2_13=
| t8_14=
| t9_22bcr_abl=
| t9_22chn_ews=
| t11_14=
| t11_22dsrct=
| t11_22ews=
| t12_15=
| t12_16afh=
| t12_16liposar=
| t12_22=
| t14_18=
| t15_17=
| t16_21=
| t17_22=
| t21_22=
| tx_1=
| tx_17=
| tx_18=
}}
=====Other molecular tests=====
{{Case Molecular
| blank=Dr Torres would ask why!
| alk =
| b_cell_clone =
| bcl2 =
| braf =
| EBV_pcr =
| egrf =
| h3f3a =
| hhv8_pcr =
| identity_test =
| idh1_2 =
| jak2_v617f =
| kit =
| loh_1p19q =
| t_cell_clone =
}}

===Diagnosis===
{{hidden|Diagnosis|<center>ARIAS STELLA CHANGES/REACTION. The diagnosis in this case is straightforward and relatively easy in this very young patient with a positive pregnancy test. However, it can be challenging in an older patient who comes in with bleeding. Arias Stella reaction shows endometrial glands lined by clear cells with atypia. Intranuclear inclusions (arrow) are often present. There can be occasional mitotic activity, which can further heighten its mimicry to clear cell carcinoma. Furthermore, the clear cells of Arias Stella are positive for Napsin and HNF1Beta, markers that are positive in clear cell carcinoma. AMACR is reportedly negative in Arias Stella while being positive in clear cell carcinoma although too few cases are tested to be confident of this claim. </center>}}
<br>
===Other cases===
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