Chordoma - Revision history

Michael: wiify

2016-07-31T19:36:43Z

wiify

← Older revision		Revision as of 19:36, 31 July 2016
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	\| LMDDx = [[chondrosarcoma]], [[myxoid lesions]], [[parachordoma]], chordoid lesions (e.g. chordoid glioma, [[chordoid meningioma]]), [[metastasis]] (e.g. [[clear cell renal cell carcinoma]])		\| LMDDx = [[chondrosarcoma]], [[myxoid lesions]], [[parachordoma]], chordoid lesions (e.g. chordoid glioma, [[chordoid meningioma]]), [[metastasis]] (e.g. [[clear cell renal cell carcinoma]])
	\| Stains =		\| Stains =
	\| IHC = S-100 +ve, AE1/AE3 +ve, Brachyury +ve, EMA +ve		\| IHC = S-100 +ve, [[AE1/AE3]] +ve, Brachyury +ve, [[EMA]] +ve
	\| EM =		\| EM =
	\| Molecular =		\| Molecular =
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	Features:<ref>URL: [http://path.upmc.edu/cases/case312/micro.html http://path.upmc.edu/cases/case312/micro.html]. Accessed on: 14 January 2012.</ref><ref name=pmid2431128>{{Cite journal \| last1 = Coindre \| first1 = JM. \| last2 = Rivel \| first2 = J. \| last3 = Trojani \| first3 = M. \| last4 = De Mascarel \| first4 = I. \| last5 = De Mascarel \| first5 = A. \| title = Immunohistological study in chordomas. \| journal = J Pathol \| volume = 150 \| issue = 1 \| pages = 61-3 \| month = Sep \| year = 1986 \| doi = 10.1002/path.1711500110 \| PMID = 2431128 }}</ref>		Features:<ref>URL: [http://path.upmc.edu/cases/case312/micro.html http://path.upmc.edu/cases/case312/micro.html]. Accessed on: 14 January 2012.</ref><ref name=pmid2431128>{{Cite journal \| last1 = Coindre \| first1 = JM. \| last2 = Rivel \| first2 = J. \| last3 = Trojani \| first3 = M. \| last4 = De Mascarel \| first4 = I. \| last5 = De Mascarel \| first5 = A. \| title = Immunohistological study in chordomas. \| journal = J Pathol \| volume = 150 \| issue = 1 \| pages = 61-3 \| month = Sep \| year = 1986 \| doi = 10.1002/path.1711500110 \| PMID = 2431128 }}</ref>
	*S-100 +ve - '''important'''.		*S-100 +ve - '''important'''.
	*AE1/AE3 +ve - '''important'''.		*[[AE1/AE3]] +ve - '''important'''.
	*Brachyury +ve - '''key stain'''.		*Brachyury +ve - '''key stain'''.
	**Protein important for axial development, affects notochord development.<ref name=omim601397>{{OMIM\|601397}}</ref>		**Protein important for axial development, affects notochord development.<ref name=omim601397>{{OMIM\|601397}}</ref>
	**''Brachyury'' literally means ''short tail''.<ref>URL: [http://www.jstor.org/pss/86845 http://www.jstor.org/pss/86845]. Accessed on: 18 May 2010.</ref>		**''Brachyury'' literally means ''short tail''.<ref>URL: [http://www.jstor.org/pss/86845 http://www.jstor.org/pss/86845]. Accessed on: 18 May 2010.</ref>
	*EMA +ve.		*[[EMA]] +ve.
	*PAX8 -ve (1 +ve (weak) of 12.<ref name=pmid21102418>{{Cite journal \| last1 = Sangoi \| first1 = AR. \| last2 = Karamchandani \| first2 = J. \| last3 = Lane \| first3 = B. \| last4 = Higgins \| first4 = JP. \| last5 = Rouse \| first5 = RV. \| last6 = Brooks \| first6 = JD. \| last7 = McKenney \| first7 = JK. \| title = Specificity of brachyury in the distinction of chordoma from clear cell renal cell carcinoma and germ cell tumors: a study of 305 cases. \| journal = Mod Pathol \| volume = 24 \| issue = 3 \| pages = 425-9 \| month = Mar \| year = 2011 \| doi = 10.1038/modpathol.2010.196 \| PMID = 21102418 }}</ref>).		*[[PAX8]] -ve (1 +ve (weak) of 12.<ref name=pmid21102418>{{Cite journal \| last1 = Sangoi \| first1 = AR. \| last2 = Karamchandani \| first2 = J. \| last3 = Lane \| first3 = B. \| last4 = Higgins \| first4 = JP. \| last5 = Rouse \| first5 = RV. \| last6 = Brooks \| first6 = JD. \| last7 = McKenney \| first7 = JK. \| title = Specificity of brachyury in the distinction of chordoma from clear cell renal cell carcinoma and germ cell tumors: a study of 305 cases. \| journal = Mod Pathol \| volume = 24 \| issue = 3 \| pages = 425-9 \| month = Mar \| year = 2011 \| doi = 10.1038/modpathol.2010.196 \| PMID = 21102418 }}</ref>).
	*Other keratins:<ref name=pmid9195570>{{Cite journal \| last1 = Naka \| first1 = T. \| last2 = Iwamoto \| first2 = Y. \| last3 = Shinohara \| first3 = N. \| last4 = Chuman \| first4 = H. \| last5 = Fukui \| first5 = M. \| last6 = Tsuneyoshi \| first6 = M. \| title = Cytokeratin subtyping in chordomas and the fetal notochord: an immunohistochemical analysis of aberrant expression. \| journal = Mod Pathol \| volume = 10 \| issue = 6 \| pages = 545-51 \| month = Jun \| year = 1997 \| doi = \| PMID = 9195570 }}</ref>		*Other keratins:<ref name=pmid9195570>{{Cite journal \| last1 = Naka \| first1 = T. \| last2 = Iwamoto \| first2 = Y. \| last3 = Shinohara \| first3 = N. \| last4 = Chuman \| first4 = H. \| last5 = Fukui \| first5 = M. \| last6 = Tsuneyoshi \| first6 = M. \| title = Cytokeratin subtyping in chordomas and the fetal notochord: an immunohistochemical analysis of aberrant expression. \| journal = Mod Pathol \| volume = 10 \| issue = 6 \| pages = 545-51 \| month = Jun \| year = 1997 \| doi = \| PMID = 9195570 }}</ref>
	**CK8 +ve (16/16).		**CK8 +ve (16/16).
	**CK19 +ve (16/16).		**CK19 +ve (16/16).
	**CK18 +ve/-ve (9 +ve/16).		**CK18 +ve/-ve (9 +ve/16).
	**CK7 -ve (1 +ve/16).		**[[CK7]] -ve (1 +ve/16).
	**CK20 -ve (0 +ve/16).		**[[CK20]] -ve (0 +ve/16).

	Classic chordoma panel:<ref name=pmid24296480>{{Cite journal \| last1 = Shen \| first1 = J. \| last2 = Shi \| first2 = Q. \| last3 = Lu \| first3 = J. \| last4 = Wang \| first4 = DL. \| last5 = Zou \| first5 = TM. \| last6 = Yang \| first6 = HL. \| last7 = Zhu \| first7 = GQ. \| title = Histological study of chordoma origin from fetal notochordal cell rests. \| journal = Spine (Phila Pa 1976) \| volume = 38 \| issue = 25 \| pages = 2165-70 \| month = Dec \| year = 2013 \| doi = 10.1097/BRS.0000000000000010 \| PMID = 24296480 }}</ref>		Classic chordoma panel:<ref name=pmid24296480>{{Cite journal \| last1 = Shen \| first1 = J. \| last2 = Shi \| first2 = Q. \| last3 = Lu \| first3 = J. \| last4 = Wang \| first4 = DL. \| last5 = Zou \| first5 = TM. \| last6 = Yang \| first6 = HL. \| last7 = Zhu \| first7 = GQ. \| title = Histological study of chordoma origin from fetal notochordal cell rests. \| journal = Spine (Phila Pa 1976) \| volume = 38 \| issue = 25 \| pages = 2165-70 \| month = Dec \| year = 2013 \| doi = 10.1097/BRS.0000000000000010 \| PMID = 24296480 }}</ref>

Michael: /* Images */ another chordoma

2016-03-19T03:57:35Z

Images: another chordoma

← Older revision		Revision as of 03:57, 19 March 2016
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	</gallery>		</gallery>
	====Case 2====		====Case 2====
			<gallery>
			Image: Chordoma -- low mag.jpg \| Chordoma - low mag. (WC)
			Image: Chordoma -- intermed mag.jpg \| Chordoma - intermed. mag. (WC)
			Image: Chordoma - alt -- intermed mag.jpg \| Chordoma - intermed. mag. (WC)
			Image: Chordoma -- high mag.jpg \| Chordoma - high mag. (WC)
			</gallery>
			====Case 3====
	<gallery>		<gallery>
	Image:Bone Chordoma 2 HP2.JPG\|Physaliphorous cells. (SKB)		Image:Bone Chordoma 2 HP2.JPG\|Physaliphorous cells. (SKB)

Michael: /* IHC */ +PAX8

2016-01-24T20:47:25Z

IHC: +PAX8

← Older revision		Revision as of 20:47, 24 January 2016
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	**''Brachyury'' literally means ''short tail''.<ref>URL: [http://www.jstor.org/pss/86845 http://www.jstor.org/pss/86845]. Accessed on: 18 May 2010.</ref>		**''Brachyury'' literally means ''short tail''.<ref>URL: [http://www.jstor.org/pss/86845 http://www.jstor.org/pss/86845]. Accessed on: 18 May 2010.</ref>
	*EMA +ve.		*EMA +ve.
			*PAX8 -ve (1 +ve (weak) of 12.<ref name=pmid21102418>{{Cite journal \| last1 = Sangoi \| first1 = AR. \| last2 = Karamchandani \| first2 = J. \| last3 = Lane \| first3 = B. \| last4 = Higgins \| first4 = JP. \| last5 = Rouse \| first5 = RV. \| last6 = Brooks \| first6 = JD. \| last7 = McKenney \| first7 = JK. \| title = Specificity of brachyury in the distinction of chordoma from clear cell renal cell carcinoma and germ cell tumors: a study of 305 cases. \| journal = Mod Pathol \| volume = 24 \| issue = 3 \| pages = 425-9 \| month = Mar \| year = 2011 \| doi = 10.1038/modpathol.2010.196 \| PMID = 21102418 }}</ref>).
	*Other keratins:<ref name=pmid9195570>{{Cite journal \| last1 = Naka \| first1 = T. \| last2 = Iwamoto \| first2 = Y. \| last3 = Shinohara \| first3 = N. \| last4 = Chuman \| first4 = H. \| last5 = Fukui \| first5 = M. \| last6 = Tsuneyoshi \| first6 = M. \| title = Cytokeratin subtyping in chordomas and the fetal notochord: an immunohistochemical analysis of aberrant expression. \| journal = Mod Pathol \| volume = 10 \| issue = 6 \| pages = 545-51 \| month = Jun \| year = 1997 \| doi = \| PMID = 9195570 }}</ref>		*Other keratins:<ref name=pmid9195570>{{Cite journal \| last1 = Naka \| first1 = T. \| last2 = Iwamoto \| first2 = Y. \| last3 = Shinohara \| first3 = N. \| last4 = Chuman \| first4 = H. \| last5 = Fukui \| first5 = M. \| last6 = Tsuneyoshi \| first6 = M. \| title = Cytokeratin subtyping in chordomas and the fetal notochord: an immunohistochemical analysis of aberrant expression. \| journal = Mod Pathol \| volume = 10 \| issue = 6 \| pages = 545-51 \| month = Jun \| year = 1997 \| doi = \| PMID = 9195570 }}</ref>
	**CK8 +ve (16/16).		**CK8 +ve (16/16).

Michael at 19:58, 14 January 2016

2016-01-14T19:58:20Z

← Older revision		Revision as of 19:58, 14 January 2016
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	*It is a malignant [[bone tumour]] (1-4% of all primary bone tumors).		*It is a malignant [[bone tumour]] (1-4% of all primary bone tumors).
	*Usually after age 30.		*Usually after age 30.
	*Comes in three flavours:
	**Chordoma, NOS (ICD-O: 9370/3)		===Classification===
	** Chondroid chordoma (ICD-O: 9371/3)		* Chordoma, NOS (ICD-O: 9370/3).
	** Dedifferentiated chordoma (ICD-O: 9372/3)		* Chondroid chordoma (ICD-O: 9371/3).
			* Dedifferentiated chordoma (ICD-O: 9372/3).

	==Gross==		==Gross==

Michael: /* Images */

2016-01-14T18:31:07Z

Images

← Older revision		Revision as of 18:31, 14 January 2016
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	===Images===		===Images===
			====Case 1====
	<gallery>		<gallery>
	Image:Chordoma_-_low_mag.jpg \| Chordoma - low mag. (WC)		Image:Chordoma_-_low_mag.jpg \| Chordoma - low mag. (WC)
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	Image:Chordoma_-_high_mag.jpg \| Chordoma - high mag. (WC)		Image:Chordoma_-_high_mag.jpg \| Chordoma - high mag. (WC)
	Image:Chordoma - very high mag.jpg\| Chordoma - very high mag. (WC)		Image:Chordoma - very high mag.jpg\| Chordoma - very high mag. (WC)
			</gallery>
			====Case 2====
			<gallery>
	Image:Bone Chordoma 2 HP2.JPG\|Physaliphorous cells. (SKB)		Image:Bone Chordoma 2 HP2.JPG\|Physaliphorous cells. (SKB)
	Image:Bone Chordoma 2 LP PA.JPG\|Low power view. Somewhat lobulated tumour with loose areas, cellular areas and fibrous septa. (SKB)		Image:Bone Chordoma 2 LP PA.JPG\|Low power view. Somewhat lobulated tumour with loose areas, cellular areas and fibrous septa. (SKB)
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	Image:Bone Chordoma HP PA.JPG\|Chordoma cells may form sheets of cells with eosinophilic cytoplasm. (SKB)		Image:Bone Chordoma HP PA.JPG\|Chordoma cells may form sheets of cells with eosinophilic cytoplasm. (SKB)
	</gallery>		</gallery>
	www:		====www====
	*[http://path.upmc.edu/cases/case64.html Chordoma (upmc.edu)].		*[http://path.upmc.edu/cases/case64.html Chordoma (upmc.edu)].
	*[http://path.upmc.edu/cases/case312/micro.html Chordoma - sacrum - several images (upmc.edu)].		*[http://path.upmc.edu/cases/case312/micro.html Chordoma - sacrum - several images (upmc.edu)].

Michael: /* See also */

2016-01-14T18:03:23Z

Michael: /* IHC */

2016-01-14T17:34:07Z

IHC

← Older revision		Revision as of 17:34, 14 January 2016
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	==IHC==		==IHC==
	Features:<ref>URL: [http://path.upmc.edu/cases/case312/micro.html http://path.upmc.edu/cases/case312/micro.html]. Accessed on: 14 January 2012.</ref><ref name=pmid2431128>{{Cite journal \| last1 = Coindre \| first1 = JM. \| last2 = Rivel \| first2 = J. \| last3 = Trojani \| first3 = M. \| last4 = De Mascarel \| first4 = I. \| last5 = De Mascarel \| first5 = A. \| title = Immunohistological study in chordomas. \| journal = J Pathol \| volume = 150 \| issue = 1 \| pages = 61-3 \| month = Sep \| year = 1986 \| doi = 10.1002/path.1711500110 \| PMID = 2431128 }}</ref>		Features:<ref>URL: [http://path.upmc.edu/cases/case312/micro.html http://path.upmc.edu/cases/case312/micro.html]. Accessed on: 14 January 2012.</ref><ref name=pmid2431128>{{Cite journal \| last1 = Coindre \| first1 = JM. \| last2 = Rivel \| first2 = J. \| last3 = Trojani \| first3 = M. \| last4 = De Mascarel \| first4 = I. \| last5 = De Mascarel \| first5 = A. \| title = Immunohistological study in chordomas. \| journal = J Pathol \| volume = 150 \| issue = 1 \| pages = 61-3 \| month = Sep \| year = 1986 \| doi = 10.1002/path.1711500110 \| PMID = 2431128 }}</ref>
	*S-100 +ve.		*S-100 +ve - '''important'''.
	*AE1/AE3 +ve.		*AE1/AE3 +ve - '''important'''.
	*Brachyury +ve -- '''key stain'''.		*Brachyury +ve - '''key stain'''.
	**Protein important for axial development, affects notochord development.<ref name=omim601397>{{OMIM\|601397}}</ref>		**Protein important for axial development, affects notochord development.<ref name=omim601397>{{OMIM\|601397}}</ref>
	**''Brachyury'' literally means ''short tail''.<ref>URL: [http://www.jstor.org/pss/86845 http://www.jstor.org/pss/86845]. Accessed on: 18 May 2010.</ref>		**''Brachyury'' literally means ''short tail''.<ref>URL: [http://www.jstor.org/pss/86845 http://www.jstor.org/pss/86845]. Accessed on: 18 May 2010.</ref>

Michael: /* IHC */

2016-01-14T17:33:25Z

IHC

← Older revision		Revision as of 17:33, 14 January 2016
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	Key points:		Key points:
	*Brachyury is not a commonly stocked antibody.		*Brachyury is not a commonly stocked antibody.
	*Chordoma will be S100 '''~~AND~~''' epithelial marker positive.		*Chordoma will be S100 '''''and''''' epithelial marker positive.
	*Many other items in the DDx will be either S100 '''OR''' epithelial marker positive.		*Many other items in the DDx will be either S100 '''''or''''' epithelial marker positive.

	==See also==		==See also==

Michael: /* IHC */

2016-01-14T17:13:53Z

IHC

← Older revision		Revision as of 17:13, 14 January 2016
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	**CK7 -ve (1 +ve/16).		**CK7 -ve (1 +ve/16).
	**CK20 -ve (0 +ve/16).		**CK20 -ve (0 +ve/16).

			Classic chordoma panel:<ref name=pmid24296480>{{Cite journal \| last1 = Shen \| first1 = J. \| last2 = Shi \| first2 = Q. \| last3 = Lu \| first3 = J. \| last4 = Wang \| first4 = DL. \| last5 = Zou \| first5 = TM. \| last6 = Yang \| first6 = HL. \| last7 = Zhu \| first7 = GQ. \| title = Histological study of chordoma origin from fetal notochordal cell rests. \| journal = Spine (Phila Pa 1976) \| volume = 38 \| issue = 25 \| pages = 2165-70 \| month = Dec \| year = 2013 \| doi = 10.1097/BRS.0000000000000010 \| PMID = 24296480 }}</ref>
			*EMA, AE1/AE3, CAM5.2, vimentin, S-100.

	Key points:		Key points:
	*Brachyury is not a commonly stocked antibody.		*Brachyury is not a commonly stocked antibody.
	*Chordoma will be S100 '''AND''' ~~Epithelial~~ marker positive.		*Chordoma will be S100 '''AND''' epithelial marker positive.
	*Many other items in the ~~DDX~~ will be either S100 '''OR''' ~~Epithelial~~ marker positive.		*Many other items in the DDx will be either S100 '''OR''' epithelial marker positive.

	==See also==		==See also==

Michael: /* IHC */

2016-01-14T17:07:35Z

IHC

← Older revision		Revision as of 17:07, 14 January 2016
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	**''Brachyury'' literally means ''short tail''.<ref>URL: [http://www.jstor.org/pss/86845 http://www.jstor.org/pss/86845]. Accessed on: 18 May 2010.</ref>		**''Brachyury'' literally means ''short tail''.<ref>URL: [http://www.jstor.org/pss/86845 http://www.jstor.org/pss/86845]. Accessed on: 18 May 2010.</ref>
	*EMA +ve.		*EMA +ve.
	*~~Keratins~~:<ref name=pmid9195570>{{Cite journal \| last1 = Naka \| first1 = T. \| last2 = Iwamoto \| first2 = Y. \| last3 = Shinohara \| first3 = N. \| last4 = Chuman \| first4 = H. \| last5 = Fukui \| first5 = M. \| last6 = Tsuneyoshi \| first6 = M. \| title = Cytokeratin subtyping in chordomas and the fetal notochord: an immunohistochemical analysis of aberrant expression. \| journal = Mod Pathol \| volume = 10 \| issue = 6 \| pages = 545-51 \| month = Jun \| year = 1997 \| doi = \| PMID = 9195570 }}</ref>		*Other keratins:<ref name=pmid9195570>{{Cite journal \| last1 = Naka \| first1 = T. \| last2 = Iwamoto \| first2 = Y. \| last3 = Shinohara \| first3 = N. \| last4 = Chuman \| first4 = H. \| last5 = Fukui \| first5 = M. \| last6 = Tsuneyoshi \| first6 = M. \| title = Cytokeratin subtyping in chordomas and the fetal notochord: an immunohistochemical analysis of aberrant expression. \| journal = Mod Pathol \| volume = 10 \| issue = 6 \| pages = 545-51 \| month = Jun \| year = 1997 \| doi = \| PMID = 9195570 }}</ref>
	**CK8 +ve (16/16).		**CK8 +ve (16/16).
	**CK19 +ve (16/16).		**CK19 +ve (16/16).

← Older revision		Revision as of 18:03, 14 January 2016
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	==See also==		==See also==
	*[[CNS tumours]].		*[[CNS tumours]].
			*[[Parachordoma]].

	==References==		==References==