Clear cell carcinoma of the ovary - Revision history

Michael at 21:27, 2 July 2020

2020-07-02T21:27:13Z

← Older revision		Revision as of 21:27, 2 July 2020
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	\| LMDDx = [[serous carcinoma of the ovary]], other [[serous carcinoma]]s, other [[clear cell tumours]] (e.g. [[clear cell renal cell carcinoma]]), [[Arias-Stella reaction]] within [[endometriosis]]		\| LMDDx = [[serous carcinoma of the ovary]], other [[serous carcinoma]]s, other [[clear cell tumours]] (e.g. [[clear cell renal cell carcinoma]]), [[Arias-Stella reaction]] within [[endometriosis]]
	\| Stains =		\| Stains =
	\| IHC = HNF-1beta +ve, WT-1 -ve, CK7 +ve, CD10 -ve, CK20 -ve		\| IHC = [[HNF-1beta]] +ve, WT-1 -ve, [[CK7]] +ve, [[CD10]] -ve, CK20 -ve
	\| EM =		\| EM =
	\| Molecular =		\| Molecular =

Michael: touch

2015-01-18T23:22:35Z

touch

← Older revision		Revision as of 23:22, 18 January 2015
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	{{ Infobox diagnosis		{{ Infobox diagnosis
	\| Name = {{PAGENAME}}		\| Name = {{PAGENAME}}
	\| Image = Ovarian_clear_cell_carcinoma_-a-_very_high_mag_-_cropped.jpg		\| Image = Ovarian_clear_cell_carcinoma_-a-_very_high_mag_-_cropped.jpg
	\| Width =		\| Width =
	\| Caption = Ovarian clear cell carcinoma. [[H&E stain]].		\| Caption = Ovarian clear cell carcinoma. [[H&E stain]].

Michael at 02:40, 9 January 2014

2014-01-09T02:40:24Z

← Older revision		Revision as of 02:40, 9 January 2014
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	{{ Infobox diagnosis		{{ Infobox diagnosis
	\| Name = {{PAGENAME}}		\| Name = {{PAGENAME}}
	\| Image = ~~Ovarian clear cell carcinoma~~ - ~~very high mag~~.jpg		\| Image = Ovarian_clear_cell_carcinoma_-a-_very_high_mag_-_cropped.jpg
	\| Width =		\| Width =
	\| Caption = Ovarian clear cell carcinoma. [[H&E stain]].		\| Caption = Ovarian clear cell carcinoma. [[H&E stain]].

Michael: +infobox

2014-01-09T02:39:22Z

+infobox

← Older revision		Revision as of 02:39, 9 January 2014
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	'''Clear cell carcinoma of the ovary''', also '''ovarian clear cell carcinoma''' (abbreviated '''OCCC''', is an aggressive [[malignant]] [[ovarian tumours\|tumour of the ovary]].		{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image = Ovarian clear cell carcinoma - very high mag.jpg
			\| Width =
			\| Caption = Ovarian clear cell carcinoma. [[H&E stain]].
			\| Synonyms = ovarian clear cell carcinoma, ovarian clear cell adenocarcinoma, clear cell adenocarcinoma of the ovary
			\| Micro = cystic/tubular architecture (may be papillary and/or solid), clear cytoplasm (may be sparse), [[hobnail morphology]] - apical surface larger than basal surface ("nuclei bulge into the lumen"), +/-hyaline droplets, prominent [[nucleoli]]
			\| Subtypes =
			\| LMDDx = [[serous carcinoma of the ovary]], other [[serous carcinoma]]s, other [[clear cell tumours]] (e.g. [[clear cell renal cell carcinoma]]), [[Arias-Stella reaction]] within [[endometriosis]]
			\| Stains =
			\| IHC = HNF-1beta +ve, WT-1 -ve, CK7 +ve, CD10 -ve, CK20 -ve
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross = mass, yellow colour, usu. unilateral
			\| Grossing =
			\| Site = [[ovary]] - see ''[[ovarian tumours]]''
			\| Assdx = [[endometriosis]], [[pulmonary embolism]]
			\| Syndromes =
			\| Clinicalhx =
			\| Signs =
			\| Symptoms =
			\| Prevalence = uncommon
			\| Bloodwork =
			\| Rads =
			\| Endoscopy =
			\| Prognosis = poor
			\| Other =
			\| ClinDDx = other [[ovarian tumours]], other pelvic and abdominal tumours
			\| Tx =
			}}
			'''Clear cell carcinoma of the ovary''', also '''ovarian clear cell carcinoma''' (abbreviated '''OCCC'''), is an aggressive [[malignant]] [[ovarian tumours\|tumour of the ovary]].

	It often forms glands; thus, it is also known as '''ovarian clear cell [[adenocarcinoma]]''', and '''clear cell adenocarcinoma of the ovary'''.		It often forms glands; thus, it is also known as '''ovarian clear cell [[adenocarcinoma]]''', and '''clear cell adenocarcinoma of the ovary'''.

Michael: split out

2014-01-09T02:29:31Z

split out

← Older revision		Revision as of 02:29, 9 January 2014
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	~~#redirect~~ [[~~Ovarian_tumours#Clear_cell_carcinoma_of_the_ovary~~]]		'''Clear cell carcinoma of the ovary''', also '''ovarian clear cell carcinoma''' (abbreviated '''OCCC''', is an aggressive [[malignant]] [[ovarian tumours\|tumour of the ovary]].

			It often forms glands; thus, it is also known as '''ovarian clear cell [[adenocarcinoma]]''', and '''clear cell adenocarcinoma of the ovary'''.

			==General==
			Prognosis:
			* Worse prognosis versus other surface epithelial tumours.<ref name=pmid18035678>{{cite journal \|author=Hauptmann S, Köbel M \|title=[Prognostic factors in ovarian carcinoma] \|language=German \|journal=Verh Dtsch Ges Pathol \|volume=89 \|issue= \|pages=92-100 \|year=2005 \|pmid=18035678 \|doi= \|url=}}</ref>
			**Poor response to platinum-based chemotherapy.<ref name=pmid22885379/>
			**~2.5x risk for thromboembolism compared to other ovarian carcinomas.<ref name=pmid19922988>{{Cite journal \| last1 = Duska \| first1 = LR. \| last2 = Garrett \| first2 = L. \| last3 = Henretta \| first3 = M. \| last4 = Ferriss \| first4 = JS. \| last5 = Lee \| first5 = L. \| last6 = Horowitz \| first6 = N. \| title = When 'never-events' occur despite adherence to clinical guidelines: the case of venous thromboembolism in clear cell cancer of the ovary compared with other epithelial histologic subtypes. \| journal = Gynecol Oncol \| volume = 116 \| issue = 3 \| pages = 374-7 \| month = Mar \| year = 2010 \| doi = 10.1016/j.ygyno.2009.10.069 \| PMID = 19922988 }}</ref>

			Epidemiology:
			* Asians appear to be at an increased risk.<ref name=pmid22885379>{{Cite journal \| last1 = Offman \| first1 = SL. \| last2 = Longacre \| first2 = TA. \| title = Clear cell carcinoma of the female genital tract (not everything is as clear as it seems). \| journal = Adv Anat Pathol \| volume = 19 \| issue = 5 \| pages = 296-312 \| month = Sep \| year = 2012 \| doi = 10.1097/PAP.0b013e31826663b1 \| PMID = 22885379 }}</ref>
			* Thought to be related to endometrioid carcinoma.<ref name=Ref_PBoD1098>{{Ref PBoD \|1098}}</ref>
			*Association with endometriosis:<ref name=pmid22885379/>
			** Increased risk of ovarian clear cell carcinoma ~ 3x.
			** Seen in 50-70% of ovarian CCC.

			==Gross==
			Features:<ref name=pmid22885379/>
			*Usually unilateral (unlike [[serous carcinoma of the ovary\|serous carcinoma]]).
			*Yellow colour.

			==Microscopic==
			Features:
			*Cystic/tubular architecture - important low power feature.
			**May be papillary and/or solid.
			*Clear cells - cytoplasm is clear - '''key feature'''. †
			*[[Hobnail morphology]] - apical surface larger than basal surface.
			**"Nuclei bulge into the lumen".
			*Hyaline droplets -- common, as in ''[[clear cell renal cell carcinoma]]''.
			**Eosinophilic bodies within lumen.
			**Seen in approximately 1/4 of cases.<ref name=pmid22885379/>
			*Nucleoli - prominent.

			Note:
			*† Clear cell adenocarcinoma does not have to have clear cells. Yes, this is stupid; it is like ''[[papillary thyroid carcinoma]]'' -- which often isn't papillary -- see ''[[no truth in names]]''.
			**The ''hobnail morphology'' is important if this is the case.

			DDx:
			*[[Serous carcinoma of the ovary]] - have larger papillae +/- branching +/-multilayered epithelium, more mitotic activity,<ref name=pmid22885379/> more group pleomorphism.
			*[[Serous borderline tumour of the ovary]].
			*High-grade [[endometrioid carcinoma of the ovary]].
			*[[Metastasis\|Metatstatic]] [[clear cell carcinoma]], esp. [[clear cell renal cell carcinoma]].
			*Borderline clear cell lesion of the ovary - very rare; an under sampled carcinoma considered more probable.<ref name=pmid22885379/>
			*[[Arias-Stella reaction]] within [[endometriosis]].

			===Images===
			<gallery>
			Image:Ovarian_clear_cell_carcinoma_-a-_very_high_mag_-_cropped.jpg \| Clear cell carcinoma - very high mag. - cropped (WC)
			Image:Ovarian_clear_cell_carcinoma_-a-_intermed_mag.jpg \| Clear cell carcinoma - intermed. mag. (WC)
			Image:Ovarian_clear_cell_carcinoma_-_low_mag.jpg \| Clear cell carcinoma - low mag. (WC)
			Image:Ovarian clear cell carcinoma - intermed mag.jpg \| Clear cell carcinoma - intermed. mag. (WC)
			Image:Ovarian clear cell carcinoma - high mag.jpg \| Clear cell carcinoma - high mag. (WC)
			Image:Ovarian clear cell carcinoma - very high mag.jpg \| Clear cell carcinoma - very high mag. (WC)
			</gallery>
			www:
			*[http://path.upmc.edu/cases/case343.html Clear cell carcinoma of the ovary - several images (upmc.edu)].

			==IHC==
			*HNF-1beta +ve.<ref>{{Cite journal \| last1 = Tsuchiya \| first1 = A. \| last2 = Sakamoto \| first2 = M. \| last3 = Yasuda \| first3 = J. \| last4 = Chuma \| first4 = M. \| last5 = Ohta \| first5 = T. \| last6 = Ohki \| first6 = M. \| last7 = Yasugi \| first7 = T. \| last8 = Taketani \| first8 = Y. \| last9 = Hirohashi \| first9 = S. \| title = Expression profiling in ovarian clear cell carcinoma: identification of hepatocyte nuclear factor-1 beta as a molecular marker and a possible molecular target for therapy of ovarian clear cell carcinoma. \| journal = Am J Pathol \| volume = 163 \| issue = 6 \| pages = 2503-12 \| month = Dec \| year = 2003 \| doi = \| PMID = 14633622 \| url = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1892387/?tool=pubmed }}</ref><ref name=omim189907>{{OMIM\|189907}}</ref>
			**Usu. -ve in serous carcinoma.
			*WT-1 -ve.
			**Usu. +ve in serous carcinoma.

			Panel for high grade serous vs. clear cell:<ref name=pmid18830127>{{cite journal \|author=Köbel M, Kalloger SE, Carrick J, ''et al.'' \|title=A limited panel of immunomarkers can reliably distinguish between clear cell and high-grade serous carcinoma of the ovary \|journal=Am. J. Surg. Pathol. \|volume=33 \|issue=1 \|pages=14–21 \|year=2009 \|month=January \|pmid=18830127 \|doi=10.1097/PAS.0b013e3181788546 \|url=}}</ref>
			*ER (+ve in serous),<ref name=pmid21164285>{{Cite journal \| last1 = DeLair \| first1 = D. \| last2 = Oliva \| first2 = E. \| last3 = Köbel \| first3 = M. \| last4 = Macias \| first4 = A. \| last5 = Gilks \| first5 = CB. \| last6 = Soslow \| first6 = RA. \| title = Morphologic spectrum of immunohistochemically characterized clear cell carcinoma of the ovary: a study of 155 cases. \| journal = Am J Surg Pathol \| volume = 35 \| issue = 1 \| pages = 36-44 \| month = Jan \| year = 2011 \| doi = 10.1097/PAS.0b013e3181ff400e \| PMID = 21164285 }}</ref> HNF-1beta (+ve in clear cell), WT-1 (+ve in serous).

			Others:<ref name=pmid22885379/>
			*CK7 +ve -- may be focal.
			*CK20 -ve.
			*CD10 -ve.
			**Often +ve in [[clear cell renal cell carcinoma]].

			==See also==
			*[[Serous carcinoma]].
			*[[Ovarian tumours]].
			*[[Ovary]].
			*[[Clear cell tumours]].

			==References==
			{{Reflist\|2}}

	[[Category:Diagnosis]]		[[Category:Diagnosis]]
			[[Category:Ovarian tumours]]

Michael: redirect

2012-01-15T13:26:45Z

redirect

New page

#redirect [[Ovarian_tumours#Clear_cell_carcinoma_of_the_ovary]]

[[Category:Diagnosis]]