Diffuse lung diseases - Revision history

Michael: /* Respiratory bronchiolitis-interstitial lung disease */ split out

2016-04-18T03:37:11Z

Respiratory bronchiolitis-interstitial lung disease: split out

← Older revision		Revision as of 03:37, 18 April 2016
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	*Abbreviated ''RB-ILD'' or ''RBILD''.		*Abbreviated ''RB-ILD'' or ''RBILD''.
	*[[AKA]] ''respiratory bronchiolitis-associated interstitial lung disease''.		*[[AKA]] ''respiratory bronchiolitis-associated interstitial lung disease''.
			{{Main\|Respiratory bronchiolitis-interstitial lung disease}}
	~~===General===~~
	*May be an early version of ''[[DIP]]''.
	*Associated with smoking.

	~~===Microscopic===~~
	~~Features:<ref name=Ref_PPP197-8>~~{{~~Ref PPP~~\|~~197~~-8}}~~</ref>~~
	*Brown pigmented airspace macrophages - ''smoker's macrophages'' - '''key feature'''.
	**Cannot count (distinct) granules.
	*Inflammation of the terminal bronchioles.

	~~Note:~~
	*The histologic features of RBILD may be present peri-tumoural.
	*Hemosiderin-laden macrophages have coarse granules - that one can count.

	~~DDx:~~
	*[[Desquamative interstitial pneumonia]].

	~~====Image====~~
	*[http://www.nature.com/modpathol/journal/v19/n11/fig_tab/3800671f2.html RB-ILD (nature.com)].

	==Desquamative interstitial pneumonia==		==Desquamative interstitial pneumonia==

Michael: /* Desquamative interstitial pneumonia */ split out

2016-03-21T04:05:52Z

Desquamative interstitial pneumonia: split out

← Older revision		Revision as of 04:05, 21 March 2016
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	==Desquamative interstitial pneumonia==		==Desquamative interstitial pneumonia==
	*Abbreviated ''DIP''.		*Abbreviated ''DIP''.
	~~===General===~~		{{Main\|Desquamative interstitial pneumonia}}
	*Thought to be advanced ''[[RBILD]]''.
	*Strong association with smoking.<ref name=Ref_WMSP93>{{~~Ref WMSP~~\|93}}~~</ref>~~
	**Treatment: stop smoking.

	~~===Microscopic===~~
	~~Features:~~
	*Abundant brown pigmented airspace macrophages - ''smoker's macrophages'' - '''key feature'''.
	*Architecture preserved; "linear fibrosis".

	~~Notes:~~
	*Some fields of view may be indistinguishable from [[RBILD]].

	~~DDx:~~
	*Amiodarone toxicity.
	*Fibrotic [[NSIP]].

	~~Images:~~
	*[http://pathhsw5m54.ucsf.edu/case27/dip27.html DIP (ucsf.edu)].

	~~===Stains===~~
	*Macrophages [[PAS stain\|PAS]] +ve.

	=See also=		=See also=

Michael: /* Lymphocytic interstitial pneumonia */ split out

2014-12-09T06:34:09Z

Lymphocytic interstitial pneumonia: split out

← Older revision		Revision as of 06:34, 9 December 2014
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	==Lymphocytic interstitial pneumonia==		==Lymphocytic interstitial pneumonia==
	*Often abbreviated '''''LIP'''''.		*Often abbreviated '''''LIP'''''.
	~~===General===~~		{{Main\|Lymphocytic interstitial pneumonia}}
	*Associated with autoimmune disorders ([[rheumatoid arthritis]], [[pernicious anemia]], [[Sjoegren syndrome]])<ref>URL: [http://emedicine.medscape.com/article/299643-overview http://emedicine.medscape.com/article/299643-overview]. Accessed on: 2 June 2010.</ref> and immunodeficiency.<ref name=pmid16088689>{{~~cite journal~~ \|~~author=Nicholson AG \|title=~~Lymphocytic interstitial pneumonia and other lymphoproliferative disorders in the lung \|journal=Semin Respir Crit Care Med \|volume=22 \|issue=4 \|pages=409–22 \|year=2001 \|month=August \|pmid=16088689 \|doi=10.1055/s-2001-17384 \|url=}}</ref>
	*Associated with viral infections ([[HIV]], EBV, human T-cell leukemia virus (HTLV) type 1).
	**Considered an AIDS-defining diagnosis.<ref>{{Cite journal \| last1 = Turner \| first1 = BJ. \| last2 = Eppes \| first2 = S. \| last3 = McKee \| first3 = LJ. \| last4 = Cosler \| first4 = L. \| last5 = Markson \| first5 = LE. \| title = A population-based comparison of the clinical course of children and adults with AIDS. \| journal = AIDS \| volume = 9 \| issue = 1 \| pages = 65-72 \| month = Jan \| year = 1995 \| doi = \| PMID = 7893443 }}~~</ref>~~

	~~===Gross===~~
	*Location: basilar predominance.
	*Increased interstitial markings.

	~~===Microscopic===~~
	~~Features:<ref>URL: [http://emedicine.medscape.com/article/299643-diagnosis http://emedicine.medscape.com/article/299643-diagnosis]. Accessed on: 2 June 2010.</ref>~~
	*Small mature lymphocytes (usually B cells)<ref name=afip_vol2_265>AFIP atlas of nontumour pathology. 2002. Vo. 2. P.265. ISBN 1-881041-79-4.</ref> in the interstitium of the lung.
	*Plasma cells.
	*+/-Lymphoid follicles.

	~~Negatives:~~
	*No [[vasculitis]].
	*No [[necrosis]].

	~~Images:~~
	*[http://www.scielo.br/img/revistas/jbpneu/v34n2/en_a02fig01.jpg LIP (scielo.br)].
	*[http://path.upmc.edu/cases/case176/micro.html LIP (upmc.edu)].

	~~DDx:~~
	*[[Lymphoma]].
	*Follicular bronchitis/bronchiolitis.
	*Nodular lymphoid hyperplasia.
	**This is determined in part by radiology; it has nodules radiographically.

	~~===Stains===~~
	~~To exclude infection:<ref>URL: [http://path.upmc.edu/cases/case176/dx.html http://path.upmc.edu/cases/case176/dx.html]. Accessed on: 8 January 2012.</ref>~~
	*[[GMS stain]] -ve.
	*[[Ziehl-Neelsen stain]] -ve.

	~~===IHC===~~
	*May be done to exclude lymphoma.

	==Respiratory bronchiolitis-interstitial lung disease==		==Respiratory bronchiolitis-interstitial lung disease==

Michael: /* Respiratory bronchiolitis-interstitial lung disease */

2014-07-15T13:09:25Z

Respiratory bronchiolitis-interstitial lung disease

← Older revision		Revision as of 13:09, 15 July 2014
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	Features:<ref name=Ref_PPP197-8>{{Ref PPP\|197-8}}</ref>		Features:<ref name=Ref_PPP197-8>{{Ref PPP\|197-8}}</ref>
	*Brown pigmented airspace macrophages - ''smoker's macrophages'' - '''key feature'''.		*Brown pigmented airspace macrophages - ''smoker's macrophages'' - '''key feature'''.
			**Cannot count (distinct) granules.
	*Inflammation of the terminal bronchioles.		*Inflammation of the terminal bronchioles.

	Note:		Note:
	*The histologic features of RBILD may be present peri-tumoural.		*The histologic features of RBILD may be present peri-tumoural.
			*Hemosiderin-laden macrophages have coarse granules - that one can count.

	DDx:		DDx:
	*[[Desquamative interstitial pneumonia]].		*[[Desquamative interstitial pneumonia]].

	Image:		====Image====
	*[http://www.nature.com/modpathol/journal/v19/n11/fig_tab/3800671f2.html RB-ILD (nature.com)].		*[http://www.nature.com/modpathol/journal/v19/n11/fig_tab/3800671f2.html RB-ILD (nature.com)].

Michael: /* Desquamative interstitial pneumonia */

2014-07-15T13:07:02Z

Desquamative interstitial pneumonia

← Older revision		Revision as of 13:07, 15 July 2014
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	===Stains===		===Stains===
	*Macrophages PAS +ve.		*Macrophages [[PAS stain\|PAS]] +ve.

	=See also=		=See also=

Michael: /* Histologic classification */

2014-07-15T13:06:04Z

Histologic classification

← Older revision		Revision as of 13:06, 15 July 2014
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	\| [[Usual interstitial pneumonia]] (UIP)		\| [[Usual interstitial pneumonia]] (UIP)
	\| [[collagen vascular disease\|CVD]], [[idiopathic pulmonary fibrosis\|IPF]], [[drug toxicity]], [[pneumoconiosis]]		\| [[collagen vascular disease\|CVD]], [[idiopathic pulmonary fibrosis\|IPF]], [[drug toxicity]], [[pneumoconiosis]]
	\| ~~Allergen~~ (hypersensitivity pneumonitis), idiopathic, autoimmune		\| allergen (hypersensitivity pneumonitis), idiopathic, autoimmune
	\|-		\|-
	\| [[Organizing pneumonia]]		\| [[Organizing pneumonia]]

Michael: /* Histologic classification */

2014-07-15T13:05:49Z

Histologic classification

← Older revision		Revision as of 13:05, 15 July 2014
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	\| [[Lymphocytic interstitial pneumonia]] (LIP)		\| [[Lymphocytic interstitial pneumonia]] (LIP)
	\| LIP		\| LIP
	\| ~~Viral~~/autoimmune		\| viral/autoimmune
	\|}		\|}
	ARDS = adult respiratory distress syndrome, AIP = acute interstitial pneumonia, TRALI = transfusion related acute lung injury, CVD = [[collagen vascular disease]], IPF = idiopathic pulmonary fibrosis.		ARDS = adult respiratory distress syndrome, AIP = acute interstitial pneumonia, TRALI = transfusion related acute lung injury, CVD = [[collagen vascular disease]], IPF = idiopathic pulmonary fibrosis.

Michael: /* Histologic classification */

2014-07-15T13:04:10Z

Histologic classification

← Older revision		Revision as of 13:04, 15 July 2014
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	\| [[Respiratory bronchiolitis]]		\| [[Respiratory bronchiolitis]]
	\| [[Respiratory bronchiolitis-associated interstitial lung disease\|RB-ILD]]		\| [[Respiratory bronchiolitis-associated interstitial lung disease\|RB-ILD]]
	\| ~~Smoking~~		\| smoking
	\|-		\|-
	\| [[Usual interstitial pneumonia]] (UIP)		\| [[Usual interstitial pneumonia]] (UIP)

Michael: /* Histologic classification */

2014-07-15T13:03:53Z

Histologic classification

← Older revision		Revision as of 13:03, 15 July 2014
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	\| [[Desquamative interstitial pneumonia]] (DIP)		\| [[Desquamative interstitial pneumonia]] (DIP)
	\| DIP		\| DIP
	\| ~~Smoking~~		\| [[smoking]]
	\|-		\|-
	\| [[Diffuse alveolar damage]] (DAD)		\| [[Diffuse alveolar damage]] (DAD)

Michael: /* Non-specific interstitial pneumonia */

2014-05-31T04:09:02Z

Non-specific interstitial pneumonia

← Older revision		Revision as of 04:09, 31 May 2014
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	==Non-specific interstitial pneumonia==		==Non-specific interstitial pneumonia==
	*Abbreviated ''NSIP''.		*Abbreviated ''NSIP''.
			{{Main\|Non-specific interstitial pneumonia}}
	~~===General===~~
	*Better prognosis than [[UIP]].
	*Some radiologists and pathologists don't believe in this entity.

	~~Associations:<ref name=Ref_WMSP92>~~{{~~Ref WMSP~~\|~~92}}</ref>~~
	*Connective tissue disease.
	*[[Rheumatoid arthritis]].

	~~===Gross/Radiology===~~
	*No honeycombing.
	*Fibrosis usually lower lung zone.
	*Patchy ground glass.

	~~===Microscopic===~~
	~~Features:<ref name=Ref_WMSP92>{{Ref WMSP\|92}}</ref>~~
	*Diffuse fibrosis:
	**Uniform fibrosis (unlike [[UIP]]).
	**"Linear fibrosis" has a good prognosis - ~~should be mentioned in the report.~~
	***''Linear fibrosis'' = fibrosis that follows alveolar walls + no architectural distortion.
	*+/-Lymphoid nodules - association with collagen vascular disease. (???)
	*+/-Focal [[organizing pneumonia]].

	~~Notes:~~
	*Inflammation in NSIP usually more prominent than in UIP.
	*No honeycombing - key difference between UIP and NSIP.

	~~DDx:~~
	*Collagen vascular disease.
	*Drug reaction.
	*[[Hypersensitivity pneumonitis]] (extrinic allergic alveolitis).
	*[[Lymphocytic interstitial pneumonia~~]] (LIP) - much more inflammation.~~

	==Organizing pneumonia==		==Organizing pneumonia==