Eccrine spiradenoma - Revision history

Michael: /* IHC */

2016-01-02T05:40:07Z

IHC

← Older revision		Revision as of 05:40, 2 January 2016
Line 102:		Line 102:
	*S100 +ve.		*S100 +ve.
	*Keratins 7, 8, and 18 +ve.		*Keratins 7, 8, and 18 +ve.
	*Ductules are EMA and CEA positive.		*Ductules are [[EMA]] and [[CEA]] positive.
	Notes:		Notes:
	*IHC profile essentially identical to dermal cylindroma.<ref name=pmid9129700/>		*IHC profile essentially identical to dermal cylindroma.<ref name=pmid9129700/>

Michael: /* Microscopic */

2016-01-02T05:38:33Z

Microscopic

← Older revision		Revision as of 05:38, 2 January 2016
Line 56:		Line 56:

	DDx:		DDx:
	*[[Dermal cylindroma]]-		*[[Dermal cylindroma]].
	**These two tumors are very closely related and overlap.		**These two tumors are very closely related and overlap.
	**Many tumors have areas of both spiradenoma and cylindroma.		**Many tumors have areas of both spiradenoma and cylindroma.

Michael: /* Microscopic */

2015-06-01T15:40:39Z

Microscopic

← Older revision		Revision as of 15:40, 1 June 2015
Line 48:		Line 48:
	*Biphasic cell population:		*Biphasic cell population:
	**outer dark cells with small hyperchromatic nuclei and minimal cytoplasm.		**outer dark cells with small hyperchromatic nuclei and minimal cytoplasm.
	**inner larger cells with vesicular nuclei and more cytoplasm.		**inner larger cells with [[vesicular nuclei]] and more cytoplasm.
	**In some areas the two cell types mix together with dispersed hyaline droplets.		**In some areas the two cell types mix together with dispersed hyaline droplets.
	*Ductal differentiation.		*Ductal differentiation.

Sarah: /* Microscopic */

2015-02-18T01:48:24Z

Microscopic

Sarah: /* General */

2015-02-18T01:42:00Z

General

← Older revision		Revision as of 01:42, 18 February 2015
Line 41:		Line 41:
	*Multiple lesions, early in life suggest a genetic syndrome.		*Multiple lesions, early in life suggest a genetic syndrome.
	**Brooke-Spiegler syndrome - spiradenomas, cylindromas and trichoepitheliomas		**Brooke-Spiegler syndrome - spiradenomas, cylindromas and trichoepitheliomas
	*Generally considered to be an 'eccrine' tumor but some hypothesize a pilar origin {{Cite journal \| last1 = Kazakov \| first1 = DV. \| last2 = Soukup \| first2 = R. \| last3 = Mukensnabl \| first3 = P. \| last4 = Boudova \| first4 = L. \| last5 = Michal \| first5 = M. \| title = Brooke-Spiegler syndrome: report of a case with combined lesions containing cylindromatous, spiradenomatous, trichoblastomatous, and sebaceous differentiation. \| journal = Am J Dermatopathol \| volume = 27 \| issue = 1 \| pages = 27-33 \| month = Feb \| year = 2005 \| doi = \| PMID = 15677973 }}		*Generally considered to be an 'eccrine' tumor but some hypothesize a pilar origin <ref>{{Cite journal \| last1 = Kazakov \| first1 = DV. \| last2 = Soukup \| first2 = R. \| last3 = Mukensnabl \| first3 = P. \| last4 = Boudova \| first4 = L. \| last5 = Michal \| first5 = M. \| title = Brooke-Spiegler syndrome: report of a case with combined lesions containing cylindromatous, spiradenomatous, trichoblastomatous, and sebaceous differentiation. \| journal = Am J Dermatopathol \| volume = 27 \| issue = 1 \| pages = 27-33 \| month = Feb \| year = 2005 \| doi = \| PMID = 15677973 }}</ref>

	==Microscopic==		==Microscopic==

Sarah: /* General */

2015-02-18T01:40:52Z

General

← Older revision		Revision as of 01:40, 18 February 2015
Line 41:		Line 41:
	*Multiple lesions, early in life suggest a genetic syndrome.		*Multiple lesions, early in life suggest a genetic syndrome.
	**Brooke-Spiegler syndrome - spiradenomas, cylindromas and trichoepitheliomas		**Brooke-Spiegler syndrome - spiradenomas, cylindromas and trichoepitheliomas
			*Generally considered to be an 'eccrine' tumor but some hypothesize a pilar origin {{Cite journal \| last1 = Kazakov \| first1 = DV. \| last2 = Soukup \| first2 = R. \| last3 = Mukensnabl \| first3 = P. \| last4 = Boudova \| first4 = L. \| last5 = Michal \| first5 = M. \| title = Brooke-Spiegler syndrome: report of a case with combined lesions containing cylindromatous, spiradenomatous, trichoblastomatous, and sebaceous differentiation. \| journal = Am J Dermatopathol \| volume = 27 \| issue = 1 \| pages = 27-33 \| month = Feb \| year = 2005 \| doi = \| PMID = 15677973 }}

	==Microscopic==		==Microscopic==

Sarah: /* Microscopic */

2015-02-18T01:35:50Z

Microscopic

← Older revision		Revision as of 01:35, 18 February 2015
Line 50:		Line 50:
	**In some areas the two cell types mix together with dispersed hyaline droplets.		**In some areas the two cell types mix together with dispersed hyaline droplets.
	*Ductal differentiation.		*Ductal differentiation.
	*These cells form lobules that are surrounded by hyaline or reticulin sheath or.		*These cells form lobules that are surrounded by a hyaline or reticulin sheath.
	*+/-Lymphocytes.		*+/-Lymphocytes.
	*Vascular component - large and small blood vessels.		*Vascular component - large and small blood vessels.

Sarah: /* Microscopic */

2015-02-11T11:49:44Z

Microscopic

← Older revision		Revision as of 11:49, 11 February 2015
Line 74:		Line 74:
	*[[Glomus tumour]], hemangioma or hemangiopericytoma (vascular spiradenomas).		*[[Glomus tumour]], hemangioma or hemangiopericytoma (vascular spiradenomas).
	**The location often speaks against glomus tumour.		**The location often speaks against glomus tumour.
			*Basal cell carcinoma
			**Spiradenoma is deeper, without connection to the epidermis
			**Spiradenoma lacks clefting artefact.
			**Spiradenoma lacks mitoses and prominent apoptosis.
	*Lymphoid aggregate (spiradenoma will be cytokeratin positive)		*Lymphoid aggregate (spiradenoma will be cytokeratin positive)

Sarah: /* Microscopic */

2015-02-11T11:47:18Z

Microscopic

← Older revision		Revision as of 11:47, 11 February 2015
Line 58:		Line 58:
	**These two tumors are very closely related and overlap.		**These two tumors are very closely related and overlap.
	**Many tumors have areas of both spiradenoma and cylindroma.		**Many tumors have areas of both spiradenoma and cylindroma.
	**The lobules of cylindroma are more consistently discrete and surrounded by prominent hyaline material.		**The lobules of cylindroma are
			***more consistently discrete,
			***show more a more consistent arrangement of the light and dark cells and are
			***surrounded by prominent hyaline material.
	**Individual lobules of cylindroma fit together like pieces of a puzzle.		**Individual lobules of cylindroma fit together like pieces of a puzzle.
			**Lobules of spiradenoma
			***may run together and fuse,
			***may not have a prominent hyaline surround and
			***may show more disorganization and mixing of the two cell types
	*[[Trichoepithelioma]].		*[[Trichoepithelioma]].
			**Trichoepithelioma will show
			***attempts at hair bulbs,
			***areas with more eosinophilic cytoplasm and
			***characteristic peritumoral stroma
	*[[Glomus tumour]], hemangioma or hemangiopericytoma (vascular spiradenomas).		*[[Glomus tumour]], hemangioma or hemangiopericytoma (vascular spiradenomas).
	**The location often speaks against glomus tumour.		**The location often speaks against glomus tumour.

Sarah: /* Images */

2015-02-11T11:40:03Z

Images

← Older revision		Revision as of 11:40, 11 February 2015
Line 75:		Line 75:
	Image:Skin Spiradenoma Thrombus HP 13PY174127.jpg\|Spiradenoma - vascular channels within a basaloid tumor. (SKB)		Image:Skin Spiradenoma Thrombus HP 13PY174127.jpg\|Spiradenoma - vascular channels within a basaloid tumor. (SKB)
	Image:Skin Spiradenoma Vascular Thrombus 14PY169268.jpg\|Thrombosed blood vessel within a spiradenoma. (SKB)		Image:Skin Spiradenoma Vascular Thrombus 14PY169268.jpg\|Thrombosed blood vessel within a spiradenoma. (SKB)
			Image:Skin Spiradenoma MP2 14PYSNP.jpg\|Spiradenoma - dispersed hyaline pattern. (SKB)
	</gallery>		</gallery>
	www:		www:

← Older revision		Revision as of 01:48, 18 February 2015
Line 59:		Line 59:
	**These two tumors are very closely related and overlap.		**These two tumors are very closely related and overlap.
	**Many tumors have areas of both spiradenoma and cylindroma.		**Many tumors have areas of both spiradenoma and cylindroma.
	**The lobules of cylindroma are		**The lobules of cylindroma are small
	***more consistently discrete,		***more consistently discrete,
	***show more a more consistent arrangement of the light and dark cells and are		***show more a more consistent arrangement of the light and dark cells and are
	***surrounded by prominent hyaline material.		***often surrounded by prominent hyaline material.
	**Individual lobules of cylindroma fit together like pieces of a puzzle.		**Individual lobules of cylindroma fit together like pieces of a puzzle.
	**Lobules of spiradenoma		**Lobules of spiradenoma are larger
	***may run together and fuse,		***may run together and fuse,
	***may not have a prominent hyaline surround and		***may not have a prominent hyaline surround and
Line 79:		Line 79:
	**Spiradenoma lacks clefting artefact.		**Spiradenoma lacks clefting artefact.
	**Spiradenoma lacks mitoses and prominent apoptosis.		**Spiradenoma lacks mitoses and prominent apoptosis.
			**BCC lacks ducts
			**BCC lobules lack a prominent surrounding hyaline membrane
	*Lymphoid aggregate (spiradenoma will be cytokeratin positive)		*Lymphoid aggregate (spiradenoma will be cytokeratin positive)