Granulocytic sarcoma - Revision history

Mark: cases can occasionally precede full blown AML

2023-01-10T22:09:04Z

cases can occasionally precede full blown AML

← Older revision		Revision as of 22:09, 10 January 2023
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	\| Tx = see ''[[acute myeloid leukemia]]''		\| Tx = see ''[[acute myeloid leukemia]]''
	}}		}}
	'''Granulocytic sarcoma''' is an uncommon [[malignant]] [[soft tissue lesion]] that really represents a hematologic malignancy; it is a soft tissue manifestation of [[acute myeloid leukemia]]. It is ''not'' a [[sarcoma]].		'''Granulocytic sarcoma''' is an uncommon [[malignant]] [[soft tissue lesion]] that really represents a hematologic malignancy; it is a soft tissue manifestation of [[acute myeloid leukemia]]. It is ''not'' a [[sarcoma]]. In a small number of cases, granulocytic sarcoma may precede systemic disease and may show a aleukaemic picture, i.e. there may not be significant numbers of blasts circulating in the blood.

	Numerous other terms refer to this including '''extramedullary leukemia''',<ref name=pmid21795742>{{Cite journal \| last1 = Bakst \| first1 = RL. \| last2 = Tallman \| first2 = MS. \| last3 = Douer \| first3 = D. \| last4 = Yahalom \| first4 = J. \| title = How I treat extramedullary acute myeloid leukemia. \| journal = Blood \| volume = 118 \| issue = 14 \| pages = 3785-93 \| month = Oct \| year = 2011 \| doi = 10.1182/blood-2011-04-347229 \| PMID = 21795742 }}</ref> '''myeloid sarcoma''' and '''chloroma'''.		Numerous other terms refer to this including '''extramedullary leukemia''',<ref name=pmid21795742>{{Cite journal \| last1 = Bakst \| first1 = RL. \| last2 = Tallman \| first2 = MS. \| last3 = Douer \| first3 = D. \| last4 = Yahalom \| first4 = J. \| title = How I treat extramedullary acute myeloid leukemia. \| journal = Blood \| volume = 118 \| issue = 14 \| pages = 3785-93 \| month = Oct \| year = 2011 \| doi = 10.1182/blood-2011-04-347229 \| PMID = 21795742 }}</ref> '''myeloid sarcoma''' and '''chloroma'''.

Mark: add another image; other IHC markers

2023-01-10T22:00:07Z

add another image; other IHC markers

← Older revision		Revision as of 22:00, 10 January 2023
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	Image:Chloroma_-_high_mag.jpg \| Chloroma - high mag. (WC)		Image:Chloroma_-_high_mag.jpg \| Chloroma - high mag. (WC)
	Image:Chloroma_-_very_high_mag.jpg \| Chloroma - very high mag. (WC)		Image:Chloroma_-_very_high_mag.jpg \| Chloroma - very high mag. (WC)
			Image:Myeloid sarcoma within a lymph node x40 magnification.jpg \| Myeloid sarcoma within a lymph node (WC)
	</gallery>		</gallery>
	www:		www:
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	==IHC==		==IHC==
	Features:<ref name=pmid24969631>{{Cite journal \| last1 = Seifert \| first1 = RP. \| last2 = Bulkeley \| first2 = W. \| last3 = Zhang \| first3 = L. \| last4 = Menes \| first4 = M. \| last5 = Bui \| first5 = MM. \| title = A practical approach to diagnose soft tissue myeloid sarcoma preceding or coinciding with acute myeloid leukemia. \| journal = Ann Diagn Pathol \| volume = 18 \| issue = 4 \| pages = 253-60 \| month = Aug \| year = 2014 \| doi = 10.1016/j.anndiagpath.2014.06.001 \| PMID = 24969631 }}</ref>		Features:<ref name=pmid24969631>{{Cite journal \| last1 = Seifert \| first1 = RP. \| last2 = Bulkeley \| first2 = W. \| last3 = Zhang \| first3 = L. \| last4 = Menes \| first4 = M. \| last5 = Bui \| first5 = MM. \| title = A practical approach to diagnose soft tissue myeloid sarcoma preceding or coinciding with acute myeloid leukemia. \| journal = Ann Diagn Pathol \| volume = 18 \| issue = 4 \| pages = 253-60 \| month = Aug \| year = 2014 \| doi = 10.1016/j.anndiagpath.2014.06.001 \| PMID = 24969631 }}</ref>
			Markers of immaturity:
			*CD34 +ve/-ve (5 of 9 cases).
	*CD117 +ve (9 of 9 cases).		*CD117 +ve (9 of 9 cases).
	*CD43 +ve (7 of 7 cases).		*TdT
			Myeloid markers:
			*CD43 +ve (7 of 7 cases) - sensitive, but not specific
	*Myeloperoxidase +ve (8 of 10 cases).		*Myeloperoxidase +ve (8 of 10 cases).
	*CD34 ~~+ve~~/-~~ve (5 of 9 cases).~~		*CD11c (myelomonocytic marker)
			*CD13 (granulopoietic marker)
			*CD33 (granulopoietic marker, specific but less sensitive)

			CD34, CD117 and myeloperoxidase are more commonly positive in cases showing granulopoietic differentiation, but can be negative in cases with a myelomonocytic or monocytic differentiation, where CD68, CD163 and lysozyme may be helpful.<ref name=pmid23530613>{{cite journal \|vauthors=Zhou J, Bell D, Medeiros LJ \|title=Myeloid sarcoma of the head and neck region \|journal=Arch Pathol Lab Med \|volume=137 \|issue=11 \|pages=1560–8 \|date=November 2013 \|pmid=23530613 \|doi=10.5858/arpa.2012-0537-OA \|url=}}</ref>

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Michael: /* General */

2015-09-10T21:00:38Z

General

← Older revision		Revision as of 21:00, 10 September 2015
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	==General==		==General==
	*Soft tissue manifestation of [[acute myeloid leukemia]].<ref name=pmid21556238/>		*Soft tissue manifestation of [[acute myeloid leukemia]].<ref name=pmid21556238/>
			*WBC elevated, low or normal range.<ref name=pmid25678833>{{Cite journal \| last1 = Arthur \| first1 = C. \| last2 = Cermak \| first2 = J. \| last3 = Delaunay \| first3 = J. \| last4 = Mayer \| first4 = J. \| last5 = Mazur \| first5 = G. \| last6 = Thomas \| first6 = X. \| last7 = Wierzbowska \| first7 = A. \| last8 = Jones \| first8 = MM. \| last9 = Berrak \| first9 = E. \| title = Post hoc analysis of the relationship between baseline white blood cell count and survival outcome in a randomized Phase III trial of decitabine in older patients with newly diagnosed acute myeloid leukemia. \| journal = J Blood Med \| volume = 6 \| issue = \| pages = 25-9 \| month = \| year = 2015 \| doi = 10.2147/JBM.S64067 \| PMID = 25678833 }}</ref>

	==Microscopic==		==Microscopic==

Michael at 20:40, 10 September 2015

2015-09-10T20:40:54Z

← Older revision		Revision as of 20:40, 10 September 2015
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	\| LMDDx = [[small round cell tumours]]		\| LMDDx = [[small round cell tumours]]
	\| Stains =		\| Stains =
	\| IHC =		\| IHC = CD117 +ve, CD43 +ve, CD34 +ve/-ve
	\| EM =		\| EM =
	\| Molecular =		\| Molecular =

Michael at 20:40, 10 September 2015

2015-09-10T20:40:23Z

← Older revision		Revision as of 20:40, 10 September 2015
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	*[http://path.upmc.edu/cases/case306/micro.html Granulocytic sarcoma - several crappy images (upmc.edu)].		*[http://path.upmc.edu/cases/case306/micro.html Granulocytic sarcoma - several crappy images (upmc.edu)].
	*[http://path.upmc.edu/cases/case379.html Myeloid sarcoma - several images (upmc.edu)].		*[http://path.upmc.edu/cases/case379.html Myeloid sarcoma - several images (upmc.edu)].

			==IHC==
			Features:<ref name=pmid24969631>{{Cite journal \| last1 = Seifert \| first1 = RP. \| last2 = Bulkeley \| first2 = W. \| last3 = Zhang \| first3 = L. \| last4 = Menes \| first4 = M. \| last5 = Bui \| first5 = MM. \| title = A practical approach to diagnose soft tissue myeloid sarcoma preceding or coinciding with acute myeloid leukemia. \| journal = Ann Diagn Pathol \| volume = 18 \| issue = 4 \| pages = 253-60 \| month = Aug \| year = 2014 \| doi = 10.1016/j.anndiagpath.2014.06.001 \| PMID = 24969631 }}</ref>
			*CD117 +ve (9 of 9 cases).
			*CD43 +ve (7 of 7 cases).
			*Myeloperoxidase +ve (8 of 10 cases).
			*CD34 +ve/-ve (5 of 9 cases).

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Michael: /* Microscopic */

2014-05-21T12:51:55Z

Microscopic

← Older revision		Revision as of 12:51, 21 May 2014
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	==Microscopic==		==Microscopic==
	Features:		Features:
	*Cluster of atypical small blue cells in [[soft tissue lesions\|soft tissue]].		*Cluster of atypical small blue cells in [[soft tissue lesions\|soft tissue]] with scant cytoplasm.

	~~Note~~:		DDx:
	*~~May mimic~~ [[~~small~~ cell carcinoma]]~~, large~~ cell lymphomas ([[DLBCL]], [[ALCL]]), [[small round cell tumour]]s.		*[[Small cell carcinoma]]
			*Large cell lymphomas ([[DLBCL]], [[ALCL]]).
			*Other [[small round cell tumour]]s.

	===Images===		===Images===

Michael at 21:12, 5 April 2014

2014-04-05T21:12:04Z

← Older revision		Revision as of 21:12, 5 April 2014
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	\| Caption = Chloroma. [[H&E stain]].		\| Caption = Chloroma. [[H&E stain]].
	\| Synonyms = extramedullary leukemia, myeloid sarcoma and chloroma, myeloblastoma, chloromyeloma, chloromyelosarcoma, granulocytic leukosarcoma, myelosarcoma		\| Synonyms = extramedullary leukemia, myeloid sarcoma and chloroma, myeloblastoma, chloromyeloma, chloromyelosarcoma, granulocytic leukosarcoma, myelosarcoma
	\| Micro = small blue cells ~2x resting lymphocyte, infiltrative		\| Micro = atypical small blue cells ~2x resting lymphocyte, infiltrative
	\| Subtypes =		\| Subtypes =
	\| LMDDx = [[small round cell tumours]]		\| LMDDx = [[small round cell tumours]]

Michael at 21:11, 5 April 2014

2014-04-05T21:11:38Z

← Older revision		Revision as of 21:11, 5 April 2014
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	\| Width =		\| Width =
	\| Caption = Chloroma. [[H&E stain]].		\| Caption = Chloroma. [[H&E stain]].
	\| Synonyms =		\| Synonyms = extramedullary leukemia, myeloid sarcoma and chloroma, myeloblastoma, chloromyeloma, chloromyelosarcoma, granulocytic leukosarcoma, myelosarcoma
	\| Micro =		\| Micro = small blue cells ~2x resting lymphocyte, infiltrative
	\| Subtypes =		\| Subtypes =
	\| LMDDx =		\| LMDDx = [[small round cell tumours]]
	\| Stains =		\| Stains =
	\| IHC =		\| IHC =

Michael at 21:09, 5 April 2014

2014-04-05T21:09:44Z

← Older revision		Revision as of 21:09, 5 April 2014
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			{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image = Chloroma_-_very_high_mag.jpg
			\| Width =
			\| Caption = Chloroma. [[H&E stain]].
			\| Synonyms =
			\| Micro =
			\| Subtypes =
			\| LMDDx =
			\| Stains =
			\| IHC =
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross =
			\| Grossing =
			\| Site = [[soft tissue lesion]]
			\| Assdx =
			\| Syndromes =
			\| Clinicalhx =
			\| Signs =
			\| Symptoms =
			\| Prevalence = rare
			\| Bloodwork =
			\| Rads =
			\| Endoscopy =
			\| Prognosis =
			\| Other =
			\| ClinDDx = other [[soft tissue lesions]]
			\| Tx = see ''[[acute myeloid leukemia]]''
			}}
	'''Granulocytic sarcoma''' is an uncommon [[malignant]] [[soft tissue lesion]] that really represents a hematologic malignancy; it is a soft tissue manifestation of [[acute myeloid leukemia]]. It is ''not'' a [[sarcoma]].		'''Granulocytic sarcoma''' is an uncommon [[malignant]] [[soft tissue lesion]] that really represents a hematologic malignancy; it is a soft tissue manifestation of [[acute myeloid leukemia]]. It is ''not'' a [[sarcoma]].

Michael at 21:03, 5 April 2014

2014-04-05T21:03:46Z

← Older revision		Revision as of 21:03, 5 April 2014
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	==See also==		==See also==
	*[[Soft tissue lesions]].		*[[Soft tissue lesions]].
			*[[Intravascular lymphoma]].

	==References==		==References==