Littoral cell angioma - Revision history

Mark: haemangioendothelioma variant

2018-05-20T21:40:03Z

haemangioendothelioma variant

← Older revision		Revision as of 21:40, 20 May 2018
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	\| Symptoms =		\| Symptoms =
	\| Prevalence = rare		\| Prevalence = rare
	\| Bloodwork =		\| Bloodwork =
	\| Rads = solitary hypodense lesion		\| Rads = solitary hypodense lesion
	\| Endoscopy =		\| Endoscopy =
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	\| Tx =		\| Tx =
	}}		}}
	'''Littoral cell angioma''', abbreviated '''LCA''', is an uncommon ~~benign~~ [[vascular lesions\|vascular lesion]] of the [[spleen]].		'''Littoral cell angioma''', abbreviated '''LCA''', is an uncommon [[vascular lesions\|vascular lesion]] of the [[spleen]]. Regarded as benign, rare cases have shown malignant behaviour and have been labelled as [[littoral cell hemangioendothelioma]].<ref>{{Cite journal \| last1 = Ben-Izhak \| first1 = O. \| last2 = Bejar \| first2 = J. \| last3 = Ben-Eliezer \| first3 = S. \| last4 = Vlodavsky \| first4 = E. \| title = Splenic littoral cell haemangioendothelioma: a new low-grade variant of malignant littoral cell tumour. \| journal = Histopathology \| volume = 39 \| issue = 5 \| pages = 469-75 \| month = Nov \| year = 2001 \| doi = \| PMID = 11737304 }}</ref><ref name=pmid24420309>{{Cite journal \| last1 = He \| first1 = P. \| last2 = Yan \| first2 = XD. \| last3 = Wang \| first3 = JR. \| last4 = Guo \| first4 = RC. \| last5 = Zhang \| first5 = HB. \| title = Splenic littoral cell hemangioendothelioma: report of a case with hepatic metastases and review of the literature. \| journal = J Clin Ultrasound \| volume = 42 \| issue = 5 \| pages = 308-12 \| month = Jun \| year = 2014 \| doi = 10.1002/jcu.22120 \| PMID = 24420309 }}</ref>

	''Angioma'', in general, is dealt with in ''[[vascular malformations]]''.		''Angioma'', in general, is dealt with in ''[[vascular malformations]]''.
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	Features:<ref name=pmid15329769>{{Cite journal \| last1 = Tan \| first1 = YM. \| last2 = Chuah \| first2 = KL. \| last3 = Wong \| first3 = WK. \| title = Littoral cell angioma of the spleen. \| journal = Ann Acad Med Singapore \| volume = 33 \| issue = 4 \| pages = 524-6 \| month = Jul \| year = 2004 \| doi = \| PMID = 15329769 \| url=http://www.annals.edu.sg/pdf200408/V33N4p524.pdf }}</ref>		Features:<ref name=pmid15329769>{{Cite journal \| last1 = Tan \| first1 = YM. \| last2 = Chuah \| first2 = KL. \| last3 = Wong \| first3 = WK. \| title = Littoral cell angioma of the spleen. \| journal = Ann Acad Med Singapore \| volume = 33 \| issue = 4 \| pages = 524-6 \| month = Jul \| year = 2004 \| doi = \| PMID = 15329769 \| url=http://www.annals.edu.sg/pdf200408/V33N4p524.pdf }}</ref>
	*Rare.		*Rare.
	*Benign.		*Benign (except for rare cases - see above)

	Clinical:<ref name=pmid15329769/><ref name=pmid11547761>{{Cite journal \| last1 = Dascalescu \| first1 = CM. \| last2 = Wendum \| first2 = D. \| last3 = Gorin \| first3 = NC. \| title = Littoral-cell angioma as a cause of splenomegaly. \| journal = N Engl J Med \| volume = 345 \| issue = 10 \| pages = 772-3 \| month = Sep \| year = 2001 \| doi = 10.1056/NEJM200109063451016 \| PMID = 11547761 \| url=http://www.nejm.org/doi/full/10.1056/NEJM200109063451016 }}</ref>		Clinical:<ref name=pmid15329769/><ref name=pmid11547761>{{Cite journal \| last1 = Dascalescu \| first1 = CM. \| last2 = Wendum \| first2 = D. \| last3 = Gorin \| first3 = NC. \| title = Littoral-cell angioma as a cause of splenomegaly. \| journal = N Engl J Med \| volume = 345 \| issue = 10 \| pages = 772-3 \| month = Sep \| year = 2001 \| doi = 10.1056/NEJM200109063451016 \| PMID = 11547761 \| url=http://www.nejm.org/doi/full/10.1056/NEJM200109063451016 }}</ref>
	*Pyrexia (fever), splenomegaly, weight loss, solitary hypodense lesion on imaging.		*Pyrexia (fever), splenomegaly, weight loss, solitary hypodense lesion on imaging.
			*Regarded as benign
			*Case series show strong association with synchronous malignancy.<ref name=pmid24987971>{{Cite journal \| last1 = Sarandria \| first1 = JJ. \| last2 = Escano \| first2 = M. \| last3 = Kamangar \| first3 = F. \| last4 = Farooqui \| first4 = S. \| last5 = Montgomery \| first5 = E. \| last6 = Cunningham \| first6 = SC. \| title = Massive splenomegaly correlates with malignancy: 180 cases of splenic littoral cell tumors in the world literature. \| journal = Minerva Chir \| volume = 69 \| issue = 4 \| pages = 229-37 \| month = Aug \| year = 2014 \| doi = \| PMID = 24987971 }}</ref>

	Note:		Note:

Mark: CD21+

2018-05-20T21:33:24Z

CD21+

← Older revision		Revision as of 21:33, 20 May 2018
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	==IHC==		==IHC==
	~~Features~~:<ref name=pmid15329769/>		Normal littoral cells express CD8+, macrophage/histiocytic markers and vascular markers. In comparison, littoral cell angioma is:<ref name=pmid15329769/>
	*CD68 +ve.		*CD68 +ve (and other histiocytic markers)
	*CD31 +ve		*CD31 +ve (and other vascular markers, e.g. Factor VIII, but ''not'' CD34)

	~~Others:~~
	*CD34 -ve (normally in red pulp).<ref name=pmid15329769/>		*CD34 -ve (normally in red pulp).<ref name=pmid15329769/>
	*CD8 -ve (normally in red pulp).<ref name=pmid15329769/>		*CD8 -ve (normally in red pulp).<ref name=pmid15329769/>
	*~~Factor VIII~~ +ve.		*CD21 +ve (at least focally)

	==See also==		==See also==

Mitchell: /* Images */added a case

2016-12-14T23:32:03Z

Images: added a case

← Older revision		Revision as of 23:32, 14 December 2016
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	*[http://www.webpathology.com/image.asp?n=5&Case=382 LCA - low mag. (webpathology.com)].		*[http://www.webpathology.com/image.asp?n=5&Case=382 LCA - low mag. (webpathology.com)].
	*[http://www.webpathology.com/image.asp?n=6&Case=382 LCA - high mag. (webpathology.com)].		*[http://www.webpathology.com/image.asp?n=6&Case=382 LCA - high mag. (webpathology.com)].

			[[File:3 18031130010902 sl 1.png\|Littoral cell angioma of spleen]]
			[[File:3 18031130010902 sl 2.png\|Littoral cell angioma of spleen]]
			[[File:3 18031130010902 sl 3.png\|Littoral cell angioma of spleen]]
			[[File:3 18031130010902 sl 4.png\|Littoral cell angioma of spleen]]


			Littorral cell angioma of spleen. A. Multiple irregular cysts and proliferated erythrocyte filled vessels. B. Plump lesional cells form the lining and are seen to lie within vascular lumens (arrows). C. Small papillae (arrows) appear to form. D. High power view shows them to be vascular lining cells, sometimes even columnar; they are enlarged endothelial cells positive for CD31, CD163, and CD68. Note the presence also of macrophages, some with hemosiderin pigment.

	==IHC==		==IHC==

Michael: /* Microscopic */

2014-04-11T15:26:15Z

Microscopic

← Older revision		Revision as of 15:26, 11 April 2014
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	**[[Hemangiopericytoma]].		**[[Hemangiopericytoma]].
	**[[Splenic hamartoma]].		**[[Splenic hamartoma]].
	**Splenic [[hemangioma]].		**Splenic [[hemangioma]].<ref>URL: [http://www.webpathology.com/image.asp?n=2&Case=382 http://www.webpathology.com/image.asp?n=2&Case=382]. Accessed on: 11 April 2014.</ref>

	===Images===		===Images===

Michael: /* Microscopic */

2014-04-11T13:30:55Z

Microscopic

← Older revision		Revision as of 13:30, 11 April 2014
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	**[[Hemangiopericytoma]].		**[[Hemangiopericytoma]].
	**[[Splenic hamartoma]].		**[[Splenic hamartoma]].
			**Splenic [[hemangioma]].

	===Images===		===Images===

Michael at 20:27, 8 April 2014

2014-04-08T20:27:14Z

← Older revision		Revision as of 20:27, 8 April 2014
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	\| LMDDx = [[hemangioendothelioma]], [[angiosarcoma]], [[hemangiopericytoma]], [[splenic hamartoma]]		\| LMDDx = [[hemangioendothelioma]], [[angiosarcoma]], [[hemangiopericytoma]], [[splenic hamartoma]]
	\| Stains =		\| Stains =
	\| IHC =		\| IHC = lining cells: CD68 +ve, CD31 +ve, CD34 -ve, CD8 -ve
	\| EM =		\| EM =
	\| Molecular =		\| Molecular =

Michael: /* IHC */

2014-04-08T20:26:16Z

IHC

← Older revision		Revision as of 20:26, 8 April 2014
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	Others:		Others:
	*CD34 -ve.		*CD34 -ve (normally in red pulp).<ref name=pmid15329769/>
			*CD8 -ve (normally in red pulp).<ref name=pmid15329769/>
	*Factor VIII +ve.		*Factor VIII +ve.

Michael at 21:24, 16 February 2014

2014-02-16T21:24:51Z

← Older revision		Revision as of 21:24, 16 February 2014
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	{{ Infobox diagnosis		{{ Infobox diagnosis
	\| Name = {{PAGENAME}}		\| Name = {{PAGENAME}}
	\| Image =		\| Image = Littoral_cell_angioma_of_the_spleen_-_low_mag.jpg
	\| Width =		\| Width =
	\| Caption =		\| Caption = Littoral cell angioma. [[H&E stain]].
	\| Synonyms =		\| Synonyms =
	\| Micro =		\| Micro = anastoming, small vascular channels, cystic spaces - may have papillary projections
	\| Subtypes =		\| Subtypes =
	\| LMDDx = [[hemangioendothelioma]], [[angiosarcoma]], [[hemangiopericytoma]], [[splenic hamartoma]]		\| LMDDx = [[hemangioendothelioma]], [[angiosarcoma]], [[hemangiopericytoma]], [[splenic hamartoma]]
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	\| Assdx =		\| Assdx =
	\| Syndromes =		\| Syndromes =
	\| Clinicalhx =		\| Clinicalhx = weight loss
	\| Signs =		\| Signs = pyrexia (fever), splenomegaly
	\| Symptoms =		\| Symptoms =
	\| Prevalence = rare		\| Prevalence = rare
	\| Bloodwork =		\| Bloodwork =
	\| Rads =		\| Rads = solitary hypodense lesion
	\| Endoscopy =		\| Endoscopy =
	\| Prognosis = benign		\| Prognosis = benign

Michael at 21:22, 16 February 2014

2014-02-16T21:22:53Z

← Older revision		Revision as of 21:22, 16 February 2014
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			{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image =
			\| Width =
			\| Caption =
			\| Synonyms =
			\| Micro =
			\| Subtypes =
			\| LMDDx = [[hemangioendothelioma]], [[angiosarcoma]], [[hemangiopericytoma]], [[splenic hamartoma]]
			\| Stains =
			\| IHC =
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross =
			\| Grossing =
			\| Site = [[spleen]]
			\| Assdx =
			\| Syndromes =
			\| Clinicalhx =
			\| Signs =
			\| Symptoms =
			\| Prevalence = rare
			\| Bloodwork =
			\| Rads =
			\| Endoscopy =
			\| Prognosis = benign
			\| Other =
			\| ClinDDx =
			\| Tx =
			}}
	'''Littoral cell angioma''', abbreviated '''LCA''', is an uncommon benign [[vascular lesions\|vascular lesion]] of the [[spleen]].		'''Littoral cell angioma''', abbreviated '''LCA''', is an uncommon benign [[vascular lesions\|vascular lesion]] of the [[spleen]].

Michael: /* Images */

2014-02-16T21:21:11Z

Images

← Older revision		Revision as of 21:21, 16 February 2014
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	===Images===		===Images===
	~~www:~~
	*[http://www.webpathology.com/image.asp?n=5&Case=382 LCA - low mag. (webpathology.com)].
	*[http://www.webpathology.com/image.asp?n=6&Case=382 LCA - high mag. (webpathology.com)].
	<gallery>		<gallery>
	Image:Littoral_cell_angioma_of_the_spleen_-_very_low_mag.jpg \| LCA - very low mag. (WC)		Image:Littoral_cell_angioma_of_the_spleen_-_very_low_mag.jpg \| LCA - very low mag. (WC)
			Image:Littoral_cell_angioma_of_the_spleen_-_low_mag.jpg \| LCA - low mag. (WC)
	Image:Littoral_cell_angioma_of_the_spleen_-_intermed_mag.jpg \| LCA - intermed. mag. (WC)		Image:Littoral_cell_angioma_of_the_spleen_-_intermed_mag.jpg \| LCA - intermed. mag. (WC)
			Image:Littoral_cell_angioma_of_the_spleen_-_high_mag.jpg \| LCA - high mag. (WC)
	Image:Littoral_cell_angioma_of_the_spleen_-_very_high_mag.jpg \| LCA - very high mag. (WC)		Image:Littoral_cell_angioma_of_the_spleen_-_very_high_mag.jpg \| LCA - very high mag. (WC)
	</gallery>		</gallery>
			www:
			*[http://www.webpathology.com/image.asp?n=5&Case=382 LCA - low mag. (webpathology.com)].
			*[http://www.webpathology.com/image.asp?n=6&Case=382 LCA - high mag. (webpathology.com)].

	==IHC==		==IHC==
	Features:<ref name=pmid15329769/>		Features:<ref name=pmid15329769/>