Odontogenic tumours and cysts - Revision history

Michael: /* Adenomatoid odontogenic tumour */ split out

2019-03-24T00:54:46Z

Adenomatoid odontogenic tumour: split out

← Older revision		Revision as of 00:54, 24 March 2019
Line 126:		Line 126:

	==Adenomatoid odontogenic tumour==		==Adenomatoid odontogenic tumour==
	~~===General===~~		{{Main\|Adenomatoid odontogenic tumour}}
	*Paedatric population, typically female.
	*Recurrences rare.<ref name=pmid16270916/>

	~~Main clinical DDx:~~
	*[[Odontogenic cyst]].<ref name=pmid16270916/>

	~~Treatment:~~
	*Surgical enuclation.<ref name=pmid16270916/>

	~~===Gross===~~
	*Usually maxilla.<ref name=pmid16270916/>

	~~===Microscopic===~~
	~~Features:~~
	*Palisaded nuclei.
	*Whorled epithelium.

	~~Notes:~~
	*No stellate reticulum.

	~~DDx:~~
	*[[Ameloblastoma]].

	~~====Image====~~
	*[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1266042/figure/F2/ AOT (nih.gov)].<ref name=pmid16270916>{{~~Cite journal \| last1 = Handschel \| first1 = JG. \| last2 = Depprich \| first2 = RA. \| last3 = Zimmermann \| first3 = AC. \| last4 = Braunstein \| first4 = S. \| last5 = Kübler~~ \| ~~first5 = NR. \| title =~~ Adenomatoid odontogenic tumor of the mandible: review of the literature and report of a rare case. \| journal = Head Face Med \| volume = 1 \| issue = \| pages = 3 \| month = Aug \| year = 2005 \| doi = 10.1186/1746-160X-1-3 \| PMID = 16270916 }}~~</ref>~~

	~~===IHC===~~
	~~Features:<ref name=pmid16270916/>~~
	*CK5 +ve.
	*CK19 +ve.

	==Ameloblastic fibroma==		==Ameloblastic fibroma==

Michael: /* Odontogenic myxoma */

2019-03-18T23:46:38Z

Odontogenic myxoma

← Older revision		Revision as of 23:46, 18 March 2019
Line 185:		Line 185:
	Features:		Features:
	*Paucicellular lesion with pale staining.		*Paucicellular lesion with pale staining.

			==Squamous odontogenic tumour==
			{{Main\|Squamous odontogenic tumour}}

	=See also=		=See also=

Michael: /* Adenomatoid odontogenic tumour */

2018-08-15T18:39:59Z

Adenomatoid odontogenic tumour

← Older revision		Revision as of 18:39, 15 August 2018
Line 127:		Line 127:
	==Adenomatoid odontogenic tumour==		==Adenomatoid odontogenic tumour==
	===General===		===General===
	*Paedatric population.		*Paedatric population, typically female.
			*Recurrences rare.<ref name=pmid16270916/>

			Main clinical DDx:
			*[[Odontogenic cyst]].<ref name=pmid16270916/>

			Treatment:
			*Surgical enuclation.<ref name=pmid16270916/>

			===Gross===
			*Usually maxilla.<ref name=pmid16270916/>

	===Microscopic===		===Microscopic===
Line 142:		Line 152:
	====Image====		====Image====
	*[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1266042/figure/F2/ AOT (nih.gov)].<ref name=pmid16270916>{{Cite journal \| last1 = Handschel \| first1 = JG. \| last2 = Depprich \| first2 = RA. \| last3 = Zimmermann \| first3 = AC. \| last4 = Braunstein \| first4 = S. \| last5 = Kübler \| first5 = NR. \| title = Adenomatoid odontogenic tumor of the mandible: review of the literature and report of a rare case. \| journal = Head Face Med \| volume = 1 \| issue = \| pages = 3 \| month = Aug \| year = 2005 \| doi = 10.1186/1746-160X-1-3 \| PMID = 16270916 }}</ref>		*[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1266042/figure/F2/ AOT (nih.gov)].<ref name=pmid16270916>{{Cite journal \| last1 = Handschel \| first1 = JG. \| last2 = Depprich \| first2 = RA. \| last3 = Zimmermann \| first3 = AC. \| last4 = Braunstein \| first4 = S. \| last5 = Kübler \| first5 = NR. \| title = Adenomatoid odontogenic tumor of the mandible: review of the literature and report of a rare case. \| journal = Head Face Med \| volume = 1 \| issue = \| pages = 3 \| month = Aug \| year = 2005 \| doi = 10.1186/1746-160X-1-3 \| PMID = 16270916 }}</ref>

			===IHC===
			Features:<ref name=pmid16270916/>
			*CK5 +ve.
			*CK19 +ve.

	==Ameloblastic fibroma==		==Ameloblastic fibroma==

Michael: /* Adenomatoid odontogenic tumour */

2018-08-15T18:34:15Z

Adenomatoid odontogenic tumour

← Older revision		Revision as of 18:34, 15 August 2018
Line 140:		Line 140:
	*[[Ameloblastoma]].		*[[Ameloblastoma]].

	Image:		====Image====
	*[~~http~~://www.~~surgicalpathologyatlas~~.~~com~~/~~glfusion~~/~~mediagallery~~/~~media~~.~~php?f~~=~~0&sort~~=~~0&s~~=~~20080802170145276 AOT (surgical pathologyatlas~~.~~com)]~~.		*[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1266042/figure/F2/ AOT (nih.gov)].<ref name=pmid16270916>{{Cite journal \| last1 = Handschel \| first1 = JG. \| last2 = Depprich \| first2 = RA. \| last3 = Zimmermann \| first3 = AC. \| last4 = Braunstein \| first4 = S. \| last5 = Kübler \| first5 = NR. \| title = Adenomatoid odontogenic tumor of the mandible: review of the literature and report of a rare case. \| journal = Head Face Med \| volume = 1 \| issue = \| pages = 3 \| month = Aug \| year = 2005 \| doi = 10.1186/1746-160X-1-3 \| PMID = 16270916 }}</ref>

	==Ameloblastic fibroma==		==Ameloblastic fibroma==

Michael: /* Ameloblastoma */ split out

2014-02-23T15:07:24Z

Ameloblastoma: split out

← Older revision		Revision as of 15:07, 23 February 2014
Line 123:		Line 123:

	==Ameloblastoma==		==Ameloblastoma==
	~~===General===~~		{{Main\|Ameloblastoma}}
	*Osteous lesion.
	*Usually mandible.<ref>URL: [http://www.waent.org/archives/2010/Vol3-2/20100618-ameloblastoma/jaw-tumor.htm http://www.waent.org/archives/2010/Vol3-2/20100618-ameloblastoma/jaw-tumor.htm]. Accessed on: 30 November 2011.</ref>
	**In a review of 3677 cases, the mandible-to-maxilla ratio was 5 to 1.<ref name=pmid7633291>{{~~Cite journal~~ \| ~~last1 = Reichart \| first1 = PA. \| last2 = Philipsen \| first2 = HP. \| last3 = Sonner \| first3 = S. \| title =~~ Ameloblastoma~~: biological profile of 3677 cases. \| journal = Eur J Cancer B Oral Oncol \| volume = 31B \| issue = 2 \| pages = 86-99 \| month = Mar \| year = 1995 \| doi = \| PMID = 7633291 }}</ref>~~
	*May arise from an odontogenic cyst,<ref name=pmid10587275>{{Cite journal \| last1 = Eversole \| first1 = LR. \| title = Malignant epithelial odontogenic tumors. \| journal = Semin Diagn Pathol \| volume = 16 \| issue = 4 \| pages = 317-24 \| month = Nov \| year = 1999 \| doi = \| PMID = 10587275 }}</ref> e.g. [[dentigerous cyst]].<ref name=pmid21957386>{{Cite journal \| last1 = Moosvi \| first1 = Z. \| last2 = Tayaar \| first2 = SA. \| last3 = Kumar \| first3 = GS. \| title = Neoplastic potential of odontogenic cysts. \| journal = Contemp Clin Dent \| volume = 2 \| issue = 2 \| pages = 106-9 \| month = Apr \| year = 2011 \| doi = 10.4103/0976-237X.83073 \| PMID = 21957386 \| PMC = 3180832 }}~~</ref>~~

	~~===Classification===~~
	~~Location:~~
	~~#Intra-osseous.~~
	~~#*Locally aggressive.~~
	~~#Peripheral.~~
	~~#*Benign.~~

	~~====Subclassification of intra-osseous type====~~
	~~Histology:~~
	~~#Solid/multicystic.~~
	~~#*More commonly reoccur.~~
	~~#Unicystic.~~
	~~#*Unlikely to reoccur.~~
	~~#*Classically found in younger individuals.~~

	~~===Microscopic===~~
	Features:<ref>URL: [http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970616-7 http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970616-7]. Accessed on: March 9, 2010.</ref>
	*Stellate reticulum - star-shaped cells, found in a developing tooth.
	*Tall columnar cells.
	**Palisaded nuclei with reverse polarization.
	***Reverse polarization of nuclei = nuclei distant from the basement membrane/nuclei at pole opposite of basement membrane.
	***Palisaded nuclei = picket fence appearance; columnar-shaped nuclei with long axis perpendicular to the basement membrane -- '''key feature'''.
	**Subnuclear vacuolization.
	*+/-Giant cells.
	*+/-Subepithelial hyalinization (eosinophilic acellular amorphous material).
	**Seen deep to the basement membrane.
	*Variable morphology (see below - ''morphology'').

	~~DDx (nuclear palisading):~~
	*[[Adenomatoid odontogenic tumour]].
	*[[Ameloblastic fibroma]].

	~~====Images====~~
	~~www:~~
	*[http://www.estomatologia.com.br/diagnosticos_det2.asp?cod_diag=12 Ameloblastoma - several images (estomatologia.com.br)].
	*[http://www.cytochemistry.net/microanatomy/digestive/devtooth9.jpg Stellate reticulum (cytochemistry.net)].

	~~<gallery>~~
	~~Image: Ameloblastoma - low mag.jpg \| Ameloblastoma - low mag. (WC)~~
	~~Image: Ameloblastoma - intermed mag.jpg \| Ameloblastoma - intermed. mag. (WC)~~
	~~Image: Ameloblastoma - high mag.jpg \| Ameloblastoma - high mag. (WC)~~
	~~Image: Ameloblastoma - very high mag.jpg \| Ameloblastoma - very high mag. (WC)~~
	~~</gallery>~~

	~~====Morphology====~~
	*Not prognostic.

	~~Morphologic variants:~~
	*Follicular ameloblastoma (classic appearance).
	*Plexiform ameloblastoma (does not have prominent palisading).
	*Acanthomatous ameloblastoma.
	*Desmoplastic ameloblastoma.
	*Basaloid ameloblastoma.

	==Adenomatoid odontogenic tumour==		==Adenomatoid odontogenic tumour==

Michael: /* Images */ more

2013-07-26T20:45:30Z

Images: more

← Older revision		Revision as of 20:45, 26 July 2013
Line 167:		Line 167:

	<gallery>		<gallery>
	Image:~~Ameloblastoma_~~-~~_intermed_mag~~.jpg \| Ameloblastoma - intermed. mag. (WC)		Image: Ameloblastoma - low mag.jpg \| Ameloblastoma - low mag. (WC)
	Image:~~Ameloblastoma_~~-~~_very_high_mag~~.jpg \| Ameloblastoma - very high mag. (WC)		Image: Ameloblastoma - intermed mag.jpg \| Ameloblastoma - intermed. mag. (WC)
			Image: Ameloblastoma - high mag.jpg \| Ameloblastoma - high mag. (WC)
			Image: Ameloblastoma - very high mag.jpg \| Ameloblastoma - very high mag. (WC)
	</gallery>		</gallery>

	====Morphology====		====Morphology====
	*Not prognostic.		*Not prognostic.

Michael: /* Identifying stuff */ +image

2013-07-26T20:44:07Z

Identifying stuff: +image

← Older revision		Revision as of 20:44, 26 July 2013
Line 20:		Line 20:

	Image:		Image:
	*[http://commons.wikimedia.org/wiki/File:Tooth_in_teratoma_-_very_low_mag.jpg Tooth (WC)].		<gallery>
			Image:Tooth_in_teratoma_-_very_low_mag.jpg \| Tooth. (WC)
			</gallery>

	===Enamel 101===		===Enamel 101===

Michael: /* Ameloblastoma */

2013-07-26T18:48:11Z

Ameloblastoma

← Older revision		Revision as of 18:48, 26 July 2013
Line 159:		Line 159:
	*[[Ameloblastic fibroma]].		*[[Ameloblastic fibroma]].

	Images:		====Images====
	*www:		www:
	**[http://www.estomatologia.com.br/diagnosticos_det2.asp?cod_diag=12 Ameloblastoma - several images (estomatologia.com.br)].		*[http://www.estomatologia.com.br/diagnosticos_det2.asp?cod_diag=12 Ameloblastoma - several images (estomatologia.com.br)].
	**[http://www.cytochemistry.net/microanatomy/digestive/devtooth9.jpg Stellate reticulum (cytochemistry.net~~)].~~		*[http://www.cytochemistry.net/microanatomy/digestive/devtooth9.jpg Stellate reticulum (cytochemistry.net)].
	*[[WC]]:
	**[http://commons.wikimedia.org/wiki/File:Ameloblastoma_-_intermed_mag.jpg Ameloblastoma - intermed. mag. (WC)].
	**[http://commons.wikimedia.org/wiki/File:Ameloblastoma_-_very_high_mag.jpg Ameloblastoma - very high mag.j (WC)].

			<gallery>
			Image:Ameloblastoma_-_intermed_mag.jpg \| Ameloblastoma - intermed. mag. (WC)
			Image:Ameloblastoma_-_very_high_mag.jpg \| Ameloblastoma - very high mag. (WC)
			</gallery>
	====Morphology====		====Morphology====
	*Not prognostic.		*Not prognostic.

Michael: /* External */ +cat

2013-07-26T18:46:36Z

External: +cat

← Older revision		Revision as of 18:46, 26 July 2013
Line 235:		Line 235:

	[[Category:Head and neck pathology]]		[[Category:Head and neck pathology]]
			[[Category:Odontogenic tumours and cysts\|Odontogenic tumours and cysts]]

Michael: /* Keratocystic odontogenic tumour */

2013-07-26T14:47:20Z

Keratocystic odontogenic tumour

← Older revision		Revision as of 14:47, 26 July 2013
Line 118:		Line 118:

	==Keratocystic odontogenic tumour==		==Keratocystic odontogenic tumour==
	*Abbreviated ''KOT''.		{{Main\|Keratocystic odontogenic tumour}}
	*Previously known as ''odontogenic keratocyst'', abbreviated ''OKC''.<ref name=pmid18353202>{{~~Cite journal \| last1 = Madras \| first1 = J. \| last2 = Lapointe \| first2 = H.~~ \| ~~title =~~ Keratocystic odontogenic tumour: reclassification of the odontogenic keratocyst from cyst to tumour. \| journal = J Can Dent Assoc \| volume = 74 \| issue = 2 \| pages = 165-165h \| month = Mar \| year = 2008 \| doi = \| PMID = 18353202 }}</ref>
	~~===General===~~
	*May be associated with ''[[nevoid basal cell carcinoma syndrome]]''.

	~~====Clinical====~~
	Features:<ref name=pmid17928730>{{Cite journal \| last1 = Habibi \| first1 = A. \| last2 = Saghravanian \| first2 = N. \| last3 = Habibi \| first3 = M. \| last4 = Mellati \| first4 = E. \| last5 = Habibi \| first5 = M. \| title = Keratocystic odontogenic tumor: a 10-year retrospective study of 83 cases in an Iranian population. \| journal = J Oral Sci \| volume = 49 \| issue = 3 \| pages = 229-35 \| month = Sep \| year = 2007 \| doi = \| PMID = 17928730 }}</ref>
	*Most common presentation: swelling.

	~~===Gross===~~
	*Location: usually mandible.
	*May mimic [[ameloblastoma]] radiologically.

	~~===Microscopic===~~
	~~Features: <ref>Thompson LDR. Head and neck pathology - (Foundations in diagnostic pathology). Goldblum JR, Ed.. Churchill Livingstone. 2006. ISBN 0-443-06960-3.</ref>~~
	*Stratified epithelium (resembling squamous epithelium) with:
	**"Ribbon-like appearance" - '''important'''.
	***Typically 8-10 cell layers thick - with relatively uniform thickness.
	***Lacks rete ridges.
	**Palisaded basal cell layer.
	*Parakeratosis (keratinized cells with nuclei) - '''key feature'''.
	*Artefactual separation of epithelium from the basement membrane.

	~~DDx:~~
	*Odontogenic cyst.
	**Orthokeratinized odontogenic cyst<ref name=pmid21062939>{{Cite journal \| last1 = Macdonald-Jankowski \| first1 = DS. \| title = Orthokeratinized odontogenic cyst: a systematic review. \| journal = Dentomaxillofac Radiol \| volume = 39 \| issue = 8 \| pages = 455-67 \| month = Dec \| year = 2010 \| doi = 10.1259/dmfr/19728573 \| PMID = }}~~</ref> - usu. [[dentigerous cyst]] - has [[orthokeratosis]] instead of [[parakeratosis]].~~
	***Orthokeratosis = keratinized cells no nuclei; parakeratosis = keratinized cell with nuclei.

	~~Images:~~
	*[http://commons.wikimedia.org/wiki/File:Keratocystic_odontogenic_tumour_-_2_-_intermed_mag.jpg KOT - intermed. mag. (WC)].
	*[http://commons.wikimedia.org/wiki/File:Keratocystic_odontogenic_tumour_-_2_-_very_high_mag.jpg KOT - very high mag. (WC)].
	*[http://commons.wikimedia.org/wiki/File:Keratocystic_odontogenic_tumour_-_intermed_mag.jpg KOT - another case - intermed. mag. (WC)]
	*[http://commons.wikimedia.org/wiki/File:Keratocystic_odontogenic_tumour1.jpg KOT - poor quality (WC)].
	*[http://commons.wikimedia.org/wiki/File:Keratocystic_odontogenic_tumour2.jpg KOT - showing artefactual clefting - poor quality (WC)].
	*[http://ars.els-cdn.com/content/image/1-s2.0-S0968605305000992-gr5.jpg KOT (els-cdn.com)].<ref>URL: [http://www.sciencedirect.com/science/article/pii/S0968605305000992#fig5 http://www.sciencedirect.com/science/article/pii/S0968605305000992#fig5]. Accessed on: 11 March 2013.</ref>

	==Ameloblastoma==		==Ameloblastoma==