Osteoarthritis - Revision history

Michael: /* Gross pathology/radiology */

2016-05-11T16:02:50Z

Gross pathology/radiology

← Older revision		Revision as of 16:02, 11 May 2016
Line 54:		Line 54:
	#Loss of cartilage, especially asymmetrical.		#Loss of cartilage, especially asymmetrical.
	#*Marble-like appearance - polished appearance known as ''eburnation''.		#*Marble-like appearance - polished appearance known as ''eburnation''.
	#Osteophyte formation.		#[[Osteophyte]] formation.
	#Subchondral cysts - located where there is loss of cartilage.<ref name=pmid404905>{{Cite journal \| last1 = Resnick \| first1 = D. \| last2 = Niwayama \| first2 = G. \| last3 = Coutts \| first3 = RD. \| title = Subchondral cysts (geodes) in arthritic disorders: pathologic and radiographic appearance of the hip joint. \| journal = AJR Am J Roentgenol \| volume = 128 \| issue = 5 \| pages = 799-806 \| month = May \| year = 1977 \| doi = \| PMID = 404905 }}</ref>		#Subchondral cysts - located where there is loss of cartilage.<ref name=pmid404905>{{Cite journal \| last1 = Resnick \| first1 = D. \| last2 = Niwayama \| first2 = G. \| last3 = Coutts \| first3 = RD. \| title = Subchondral cysts (geodes) in arthritic disorders: pathologic and radiographic appearance of the hip joint. \| journal = AJR Am J Roentgenol \| volume = 128 \| issue = 5 \| pages = 799-806 \| month = May \| year = 1977 \| doi = \| PMID = 404905 }}</ref>
	#Subchondral sclerosis.		#Subchondral sclerosis.

Michael at 05:50, 26 October 2014

2014-10-26T05:50:57Z

← Older revision		Revision as of 05:50, 26 October 2014
Line 19:		Line 19:
	\| Assdx = trauma to joint, [[obesity]] (for knees), congenital disease ([[SCFE]], [[Legg–Calvé–Perthes disease]]), complication of [[avascular necrosis of the femoral head]]		\| Assdx = trauma to joint, [[obesity]] (for knees), congenital disease ([[SCFE]], [[Legg–Calvé–Perthes disease]]), complication of [[avascular necrosis of the femoral head]]
	\| Syndromes =		\| Syndromes =
	\| Clinicalhx = old ~~age~~		\| Clinicalhx = often old, +/-history of trauma
	\| Signs = joint pain worse with activity, "morning stiffness"		\| Signs =
	~~\| Symptoms =~~		\| Symptoms = joint pain worse with activity, "morning stiffness"
	\| Prevalence = very common		\| Prevalence = very common
	\| Bloodwork =		\| Bloodwork =

Michael at 05:49, 26 October 2014

2014-10-26T05:49:57Z

← Older revision		Revision as of 05:49, 26 October 2014
Line 20:		Line 20:
	\| Syndromes =		\| Syndromes =
	\| Clinicalhx = old age		\| Clinicalhx = old age
	\| Signs = joint pain		\| Signs = joint pain worse with activity, "morning stiffness"
	\| Symptoms =		\| Symptoms =
	\| Prevalence = very common		\| Prevalence = very common

Michael: /* General */

2014-10-26T05:49:18Z

General

← Older revision		Revision as of 05:49, 26 October 2014
Line 34:		Line 34:

	==General==		==General==
			Clinical:
			*Morning stiffness (<30 minutes).<ref name=pmid24881169>{{Cite journal \| last1 = Negoescu \| first1 = A. \| last2 = Ostör \| first2 = AJ. \| title = Self-management pivotal in osteoarthritis. \| journal = Practitioner \| volume = 258 \| issue = 1770 \| pages = 25-8, 3 \| month = Apr \| year = 2014 \| doi = \| PMID = 24881169 }}</ref>
			*Worse with exercise.<ref>URL: [http://www.nlm.nih.gov/medlineplus/ency/article/000423.htm http://www.nlm.nih.gov/medlineplus/ency/article/000423.htm]. Accessed on: October 25, 2014.</ref>

			Management:
			*Acetaminophen (paracetamol).
			*Other analgesics.
			*Joint replacement.

	===Risks===		===Risks===
	It is associated with:<ref name=pmid20302555>{{Cite journal \| last1 = Martel-Pelletier \| first1 = J. \| last2 = Pelletier \| first2 = JP. \| title = Is osteoarthritis a disease involving only cartilage or other articular tissues? \| journal = Eklem Hastalik Cerrahisi \| volume = 21 \| issue = 1 \| pages = 2-14 \| month = Apr \| year = 2010 \| doi = \| PMID = 20302555 \| url=http://www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--www.tevak.org-images-Eklemlinkout.png }}		It is associated with:<ref name=pmid20302555>{{Cite journal \| last1 = Martel-Pelletier \| first1 = J. \| last2 = Pelletier \| first2 = JP. \| title = Is osteoarthritis a disease involving only cartilage or other articular tissues? \| journal = Eklem Hastalik Cerrahisi \| volume = 21 \| issue = 1 \| pages = 2-14 \| month = Apr \| year = 2010 \| doi = \| PMID = 20302555 \| url=http://www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--www.tevak.org-images-Eklemlinkout.png }}
Line 39:		Line 48:
	*Advanced age.		*Advanced age.
	*Trauma.		*Trauma.
	*Unusual loading (bony misalignment, [[obesity]]).		*Unusual loading (bony misalignment, [[obesity]]).

	==Gross pathology/radiology==		==Gross pathology/radiology==

Michael at 07:41, 12 September 2014

2014-09-12T07:41:08Z

← Older revision		Revision as of 07:41, 12 September 2014
Line 15:		Line 15:
	\| IF =		\| IF =
	\| Gross = thinning/loss of cartilage, osteophyte formation, subchondral cysts, subchondral sclerosis		\| Gross = thinning/loss of cartilage, osteophyte formation, subchondral cysts, subchondral sclerosis
	\| Grossing = [[femoral head grossing]]		\| Grossing = [[femoral head grossing]], [[knee replacement specimen grossing]]
	\| Site = [[joints]], e.g. [[femoral head]], knee, shoulder		\| Site = [[joints]], e.g. [[femoral head]], knee, shoulder
	\| Assdx = trauma to joint, [[obesity]] (for knees), congenital disease ([[SCFE]], [[Legg–Calvé–Perthes disease]]), complication of [[avascular necrosis of the femoral head]]		\| Assdx = trauma to joint, [[obesity]] (for knees), congenital disease ([[SCFE]], [[Legg–Calvé–Perthes disease]]), complication of [[avascular necrosis of the femoral head]]

Michael at 05:33, 12 September 2014

2014-09-12T05:33:07Z

← Older revision		Revision as of 05:33, 12 September 2014
Line 15:		Line 15:
	\| IF =		\| IF =
	\| Gross = thinning/loss of cartilage, osteophyte formation, subchondral cysts, subchondral sclerosis		\| Gross = thinning/loss of cartilage, osteophyte formation, subchondral cysts, subchondral sclerosis
	\| Grossing =		\| Grossing = [[femoral head grossing]]
	\| Site = [[joints]], e.g. [[femoral head]], knee, shoulder		\| Site = [[joints]], e.g. [[femoral head]], knee, shoulder
	\| Assdx = trauma to joint, [[obesity]] (for knees), congenital disease ([[SCFE]], [[Legg–Calvé–Perthes disease]]), complication of [[avascular necrosis of the femoral head]]		\| Assdx = trauma to joint, [[obesity]] (for knees), congenital disease ([[SCFE]], [[Legg–Calvé–Perthes disease]]), complication of [[avascular necrosis of the femoral head]]

Michael: /* Images */

2014-07-21T22:20:56Z

Images

← Older revision		Revision as of 22:20, 21 July 2014
Line 122:		Line 122:
	Image: Degenerative joint disease - severe - alt -- low mag.jpg \| Severe DJD - low mag.		Image: Degenerative joint disease - severe - alt -- low mag.jpg \| Severe DJD - low mag.
	Image: Degenerative joint disease - severe -- intermed mag.jpg \| Severe DJD - intermed. mag.		Image: Degenerative joint disease - severe -- intermed mag.jpg \| Severe DJD - intermed. mag.
			</gallery>
			<gallery>
			Image: Degenerative joint disease -- very low mag.jpg \| Moderate DJD - very low mag.
			Image: Degenerative joint disease -- low mag.jpg \| Moderate DJD - low mag.
			Image: Degenerative joint disease - alt -- low mag.jpg \| Moderate DJD - low mag.
			Image: Degenerative joint disease -- intermed mag.jpg \| Moderate DJD - intermed. mag.
			Image: Degenerative joint disease - alt -- intermed mag.jpg \| Moderate DJD - intermed. mag.
	</gallery>		</gallery>
	www:		www:

Michael: /* Microscopic */

2014-06-18T03:50:37Z

Microscopic

← Older revision		Revision as of 03:50, 18 June 2014
Line 77:		Line 77:
	**[[Avascular necrosis of the femoral head]].		**[[Avascular necrosis of the femoral head]].
	**Trauma.		**Trauma.
	**Slipped capital femoral epiphysis (SCFE).<ref>{{Cite journal \| last1 = Abraham \| first1 = E. \| last2 = Gonzalez \| first2 = MH. \| last3 = Pratap \| first3 = S. \| last4 = Amirouche \| first4 = F. \| last5 = Atluri \| first5 = P. \| last6 = Simon \| first6 = P. \| title = Clinical implications of anatomical wear characteristics in slipped capital femoral epiphysis and primary osteoarthritis. \| journal = J Pediatr Orthop \| volume = 27 \| issue = 7 \| pages = 788-95 \| month = \| year = \| doi = 10.1097/BPO.0b013e3181558c94 \| PMID = 17878786 }}</ref>		**[[Slipped capital femoral epiphysis]] (SCFE).<ref>{{Cite journal \| last1 = Abraham \| first1 = E. \| last2 = Gonzalez \| first2 = MH. \| last3 = Pratap \| first3 = S. \| last4 = Amirouche \| first4 = F. \| last5 = Atluri \| first5 = P. \| last6 = Simon \| first6 = P. \| title = Clinical implications of anatomical wear characteristics in slipped capital femoral epiphysis and primary osteoarthritis. \| journal = J Pediatr Orthop \| volume = 27 \| issue = 7 \| pages = 788-95 \| month = \| year = \| doi = 10.1097/BPO.0b013e3181558c94 \| PMID = 17878786 }}</ref>

	===Grading===		===Grading===

Michael: /* Images */

2014-06-18T03:42:10Z

Images

← Older revision		Revision as of 03:42, 18 June 2014
Line 116:		Line 116:

	===Images===		===Images===
			<gallery>
			Image: Degenerative joint disease - severe -- very low mag.jpg \| Severe DJD - very low mag.
			Image: Degenerative joint disease - severe - alt -- very low mag.jpg \| Severe DJD - very low mag.
			Image: Degenerative joint disease - severe -- low mag.jpg \| Severe DJD - low mag.
			Image: Degenerative joint disease - severe - alt -- low mag.jpg \| Severe DJD - low mag.
			Image: Degenerative joint disease - severe -- intermed mag.jpg \| Severe DJD - intermed. mag.
			</gallery>
			www:
	*[http://ars.els-cdn.com/content/image/1-s2.0-S8756328212000683-gr1.jpg Osteoarthritis showing villous hyperplasia - panel B (els-cdn.com)].		*[http://ars.els-cdn.com/content/image/1-s2.0-S8756328212000683-gr1.jpg Osteoarthritis showing villous hyperplasia - panel B (els-cdn.com)].
	*[http://www.medpath.info/MainContent/Skeletal/3097.GIF Osteophyte (medpath.info)].<ref>URL: [http://www.medpath.info/MainContent/Skeletal/Joint_02.html http://www.medpath.info/MainContent/Skeletal/Joint_02.html]. Accessed on: 10 November 2012.</ref>		*[http://www.medpath.info/MainContent/Skeletal/3097.GIF Osteophyte (medpath.info)].<ref>URL: [http://www.medpath.info/MainContent/Skeletal/Joint_02.html http://www.medpath.info/MainContent/Skeletal/Joint_02.html]. Accessed on: 10 November 2012.</ref>

Michael: +infobox

2014-06-18T03:40:26Z

+infobox

← Older revision		Revision as of 03:40, 18 June 2014
Line 1:		Line 1:

			{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image = Degenerative joint disease - severe - alt -- low mag.jpg
			\| Width =
			\| Caption = Severe degenerative joint disease. [[H&E stain]].
			\| Synonyms =
			\| Micro = vertical clefts of the cartilage, +/-thickening of [[bone\|bony]] trabeculae, subchondral cysts (where there is cartilage loss), +/-mild inflammation (lymphocytes), +/-villous hyperplasia (synovium has finger-like projections into the joint space), osteophytes (ossified projections at the edge of the articular cartilage)
			\| Subtypes =
			\| LMDDx = [[rheumatoid arthritis]], infectious arthritis, arthritis secondary to other disease (IBD, rheumatologic condition), trauma/deformity related, [[AVN]]-related
			\| Stains =
			\| IHC =
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross = thinning/loss of cartilage, osteophyte formation, subchondral cysts, subchondral sclerosis
			\| Grossing =
			\| Site = [[joints]], e.g. [[femoral head]], knee, shoulder
			\| Assdx = trauma to joint, [[obesity]] (for knees), congenital disease ([[SCFE]], [[Legg–Calvé–Perthes disease]]), complication of [[avascular necrosis of the femoral head]]
			\| Syndromes =
			\| Clinicalhx = old age
			\| Signs = joint pain
			\| Symptoms =
			\| Prevalence = very common
			\| Bloodwork =
			\| Rads = joint space narrowing, osteophyte formation, subchondral cysts, subchondral sclerosis
			\| Endoscopy =
			\| Prognosis = benign
			\| Other =
			\| ClinDDx = other types of [[arthritis]]
			\| Tx = pain medications, joint replacement
			}}
	'''Osteoarthritis''', abbreviated '''OA''', is a degenerative disease of the joint.		'''Osteoarthritis''', abbreviated '''OA''', is a degenerative disease of the joint.