Parathyroid hyperplasia - Revision history

Michael: /* General */

2022-04-06T21:53:23Z

General

← Older revision		Revision as of 21:53, 6 April 2022
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	Note: <br>		Note: <br>
	‡ MEN 1 is often described as causing parathyroid hyperplasia; more correctly it is thought ~~to be~~ multiple parathyroid adenomas.<ref name=pmid15490065>{{cite journal \|authors=Doherty GM, Lairmore TC, DeBenedetti MK \|title=Multiple endocrine neoplasia type 1 parathyroid adenoma development over time \|journal=World J Surg \|volume=28 \|issue=11 \|pages=1139–42 \|date=November 2004 \|pmid=15490065 \|doi=10.1007/s00268-004-7560-8 \|url=}}</ref>		‡ MEN 1 and MEN 2A are often described as causing parathyroid hyperplasia; more correctly, it is thought these are actually multiple parathyroid adenomas.<ref name=pmid15490065>{{cite journal \|authors=Doherty GM, Lairmore TC, DeBenedetti MK \|title=Multiple endocrine neoplasia type 1 parathyroid adenoma development over time \|journal=World J Surg \|volume=28 \|issue=11 \|pages=1139–42 \|date=November 2004 \|pmid=15490065 \|doi=10.1007/s00268-004-7560-8 \|url=}}</ref>

	==Gross==		==Gross==

Michael: /* General */

2022-04-06T21:49:42Z

General

← Older revision		Revision as of 21:49, 6 April 2022
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	*Common cause of [[hyperparathyroidism]].		*Common cause of [[hyperparathyroidism]].
	*Usually associated with [[chronic renal failure]].		*Usually associated with [[chronic renal failure]].
	*May be syndromic - chief cell hyperplasia - associated with [[MEN 1]], [[MEN 2A]].<ref>URL: [http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970475-2 http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970475-2]. Accessed on: 29 July 2010.</ref>		*May be syndromic - chief cell hyperplasia - associated with [[MEN 1]], [[MEN 2A]].<ref>URL: [http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970475-2 http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970475-2]. Accessed on: 29 July 2010.</ref> ‡

	Treatment:		Treatment:
	*Surgical removal of all parathyroid glands & re-implantation of half of one parathyroid in the forearm.		*Surgical removal of all parathyroid glands & re-implantation of half of one parathyroid in the forearm.

			Note: <br>
			‡ MEN 1 is often described as causing parathyroid hyperplasia; more correctly it is thought to be multiple parathyroid adenomas.<ref name=pmid15490065>{{cite journal \|authors=Doherty GM, Lairmore TC, DeBenedetti MK \|title=Multiple endocrine neoplasia type 1 parathyroid adenoma development over time \|journal=World J Surg \|volume=28 \|issue=11 \|pages=1139–42 \|date=November 2004 \|pmid=15490065 \|doi=10.1007/s00268-004-7560-8 \|url=}}</ref>

	==Gross==		==Gross==
	*Parathyroid gland enlargement - classically all parathyroid glands are involved; however, some may be spared making it difficult to differentiate this from parathyroid adenoma.<ref name=Ref_PBoD8_1128>{{Ref PBoD8\|1128}}</ref>		*Parathyroid gland enlargement - classically all parathyroid glands are involved; however, some may be spared making it difficult to differentiate this from parathyroid adenoma.<ref name=Ref_PBoD8_1128>{{Ref PBoD8\|1128}}</ref>

Michael at 05:56, 8 March 2016

2016-03-08T05:56:10Z

← Older revision		Revision as of 05:56, 8 March 2016
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	*May be syndromic - chief cell hyperplasia - associated with [[MEN 1]], [[MEN 2A]].<ref>URL: [http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970475-2 http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970475-2]. Accessed on: 29 July 2010.</ref>		*May be syndromic - chief cell hyperplasia - associated with [[MEN 1]], [[MEN 2A]].<ref>URL: [http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970475-2 http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970475-2]. Accessed on: 29 July 2010.</ref>

			Treatment:
			*Surgical removal of all parathyroid glands & re-implantation of half of one parathyroid in the forearm.
	==Gross==		==Gross==
	*Parathyroid gland enlargement - classically all parathyroid glands are involved; however, some may be spared making it difficult to differentiate this from parathyroid adenoma.<ref name=Ref_PBoD8_1128>{{Ref PBoD8\|1128}}</ref>		*Parathyroid gland enlargement - classically all parathyroid glands are involved; however, some may be spared making it difficult to differentiate this from parathyroid adenoma.<ref name=Ref_PBoD8_1128>{{Ref PBoD8\|1128}}</ref>

Michael: /* Microscopic */

2016-02-26T13:35:26Z

Microscopic

← Older revision		Revision as of 13:35, 26 February 2016
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	**Increased parenchymal cells.		**Increased parenchymal cells.
	***Chief cells - usually predominant.<ref name=pmid8090603/>		***Chief cells - usually predominant.<ref name=pmid8090603/>
	***"Water-clear" cells ~~- may not be apparent~~:		***"Water-clear" cells:
	****Abundant foamy or granular cytoplasm.<ref name=pmid7487410/>		****Abundant foamy or granular cytoplasm.<ref name=pmid7487410/>
	****Mild [[nuclear pleomorphism]].		****Mild [[nuclear pleomorphism]].
			****May not be present or apparent.
	***Other parenchymal cells include: oxyphil cells and transitional oxyphil cells.		***Other parenchymal cells include: oxyphil cells and transitional oxyphil cells.

Michael: /* Images */

2016-02-26T07:01:44Z

Images

← Older revision		Revision as of 07:01, 26 February 2016
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	Image: Parathyroid hyperplasia -- high mag.jpg \| PA - high mag. (WC)		Image: Parathyroid hyperplasia -- high mag.jpg \| PA - high mag. (WC)
	</gallery>		</gallery>
			====www====
			*[https://www.flickr.com/photos/jian-hua_qiao_md/13138532173 Water clear cells in hyperplasia (flicker.com)].

	==Sign out==		==Sign out==

Michael: /* Microscopic */ tweak

2016-02-26T06:44:39Z

Microscopic: tweak

← Older revision		Revision as of 06:44, 26 February 2016
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	**Increased parenchymal cells.		**Increased parenchymal cells.
	***Chief cells - usually predominant.<ref name=pmid8090603/>		***Chief cells - usually predominant.<ref name=pmid8090603/>
	***"Water-clear" cells - may not be apparent:~~<ref name=pmid7487410/>~~		***"Water-clear" cells - may not be apparent:
	****Abundant foamy or granular cytoplasm.		****Abundant foamy or granular cytoplasm.<ref name=pmid7487410/>
	****Mild [[nuclear pleomorphism]].		****Mild [[nuclear pleomorphism]].
	***Other parenchymal cells include: oxyphil cells and transitional oxyphil cells.		***Other parenchymal cells include: oxyphil cells and transitional oxyphil cells.

Michael: /* Microscopic */

2016-02-26T06:43:20Z

Microscopic

← Older revision		Revision as of 06:43, 26 February 2016
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	**Increased parenchymal cells.		**Increased parenchymal cells.
	***Chief cells - usually predominant.<ref name=pmid8090603/>		***Chief cells - usually predominant.<ref name=pmid8090603/>
	***"Water-clear" cells:<ref name=pmid7487410/>		***"Water-clear" cells - may not be apparent:<ref name=pmid7487410/>
	****Abundant foamy or granular cytoplasm.		****Abundant foamy or granular cytoplasm.
	****Mild [[nuclear pleomorphism]].		****Mild [[nuclear pleomorphism]].

Michael at 06:42, 26 February 2016

2016-02-26T06:42:07Z

← Older revision		Revision as of 06:42, 26 February 2016
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	\| Caption = Parathyroid hyperplasia. [[H&E stain]].		\| Caption = Parathyroid hyperplasia. [[H&E stain]].
	\| Synonyms =		\| Synonyms =
	\| Micro = ~~classically have abundant~~ adipose tissue, +/-"water-clear" cells (cells with abundant granular/foamy cytoplasm, mild nuclear pleomorphism)		\| Micro = hypercellular - usu. chief cell predominant, decreased adipose tissue, +/-"water-clear" cells (cells with abundant granular/foamy cytoplasm, mild nuclear pleomorphism)
	\| Subtypes =		\| Subtypes =
	\| LMDDx = [[parathyroid adenoma]], [[parathyroid carcinoma]]		\| LMDDx = [[parathyroid adenoma]], [[parathyroid carcinoma]]

Michael: /* Gross */

2016-02-26T06:34:12Z

Gross

← Older revision		Revision as of 06:34, 26 February 2016
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	==Gross==		==Gross==
	*~~Classically~~ all parathyroid glands are involved; however, some may be spared making it difficult to differentiate this from parathyroid adenoma.<ref name=Ref_PBoD8_1128>{{Ref PBoD8\|1128}}</ref>		*Parathyroid gland enlargement - classically all parathyroid glands are involved; however, some may be spared making it difficult to differentiate this from parathyroid adenoma.<ref name=Ref_PBoD8_1128>{{Ref PBoD8\|1128}}</ref>

	==Microscopic==		==Microscopic==

Michael: /* Microscopic */

2016-02-26T06:33:15Z

Microscopic

← Older revision		Revision as of 06:33, 26 February 2016
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	==Microscopic==		==Microscopic==
	Features:		Features:
	*Hyperplastic (hypercellular) appearance:		*Hyperplastic/hypercellular appearance:
	**Decreased adipose tissue.<ref name=pmid8090603>{{Cite journal \| last1 = Yong \| first1 = JL. \| last2 = Vrga \| first2 = L. \| last3 = Warren \| first3 = BA. \| title = A study of parathyroid hyperplasia in chronic renal failure. \| journal = Pathology \| volume = 26 \| issue = 2 \| pages = 99-109 \| month = Apr \| year = 1994 \| doi = \| PMID = 8090603 }}</ref>		**Decreased adipose tissue.<ref name=pmid8090603>{{Cite journal \| last1 = Yong \| first1 = JL. \| last2 = Vrga \| first2 = L. \| last3 = Warren \| first3 = BA. \| title = A study of parathyroid hyperplasia in chronic renal failure. \| journal = Pathology \| volume = 26 \| issue = 2 \| pages = 99-109 \| month = Apr \| year = 1994 \| doi = \| PMID = 8090603 }}</ref>
	**Increased parenchymal cells.		**Increased parenchymal cells.