Perineurioma - Revision history

Michael: vauthors

2021-03-25T17:14:27Z

vauthors

← Older revision		Revision as of 17:14, 25 March 2021
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	*Intraneural perineurioma: segmental tubular enlargement of the nerve.		*Intraneural perineurioma: segmental tubular enlargement of the nerve.
	*Soft tissue perineurioma: Well circumscribed, but not encapsulated.		*Soft tissue perineurioma: Well circumscribed, but not encapsulated.
	*Sclerosing perineurioma: Predilection for hands.<ref name="pmid9414186">{{cite journal \|~~vauthors~~=Fetsch JF, Miettinen M \|title=Sclerosing perineurioma: a clinicopathologic study of 19 cases of a distinctive soft tissue lesion with a predilection for the fingers and palms of young adults \|journal=Am. J. Surg. Pathol. \|volume=21 \|issue=12 \|pages=1433–42 \|date=December 1997 \|pmid=9414186 \|doi=10.1097/00000478-199712000-00005 \|url=}}</ref>		*Sclerosing perineurioma: Predilection for hands.<ref name="pmid9414186">{{cite journal \|authors=Fetsch JF, Miettinen M \|title=Sclerosing perineurioma: a clinicopathologic study of 19 cases of a distinctive soft tissue lesion with a predilection for the fingers and palms of young adults \|journal=Am. J. Surg. Pathol. \|volume=21 \|issue=12 \|pages=1433–42 \|date=December 1997 \|pmid=9414186 \|doi=10.1097/00000478-199712000-00005 \|url=}}</ref>

	==Microscopic==		==Microscopic==
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	==Molecular==		==Molecular==
	*Frequent TRAF7 mut.<ref name="pmid28019650">{{cite journal \|~~vauthors~~=Klein CJ, Wu Y, Jentoft ME, Mer G, Spinner RJ, Dyck PJ, Dyck PJ, Mauermann ML \|title=Genomic analysis reveals frequent TRAF7 mutations in intraneural perineuriomas \|journal=Ann. Neurol. \|volume=81 \|issue=2 \|pages=316–321 \|date=February 2017 \|pmid=28019650 \|pmc=5725965 \|doi=10.1002/ana.24854 \|url=}}</ref>		*Frequent TRAF7 mut.<ref name="pmid28019650">{{cite journal \|authors=Klein CJ, Wu Y, Jentoft ME, Mer G, Spinner RJ, Dyck PJ, Dyck PJ, Mauermann ML \|title=Genomic analysis reveals frequent TRAF7 mutations in intraneural perineuriomas \|journal=Ann. Neurol. \|volume=81 \|issue=2 \|pages=316–321 \|date=February 2017 \|pmid=28019650 \|pmc=5725965 \|doi=10.1002/ana.24854 \|url=}}</ref>

	==See also==		==See also==

Jensflorian: /* Macroscopy */ +Sclerosing perineurioma

2020-09-10T08:28:21Z

Macroscopy: +Sclerosing perineurioma

← Older revision		Revision as of 08:28, 10 September 2020
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	*Intraneural perineurioma: segmental tubular enlargement of the nerve.		*Intraneural perineurioma: segmental tubular enlargement of the nerve.
	*Soft tissue perineurioma: Well circumscribed, but not encapsulated.		*Soft tissue perineurioma: Well circumscribed, but not encapsulated.
			*Sclerosing perineurioma: Predilection for hands.<ref name="pmid9414186">{{cite journal \|vauthors=Fetsch JF, Miettinen M \|title=Sclerosing perineurioma: a clinicopathologic study of 19 cases of a distinctive soft tissue lesion with a predilection for the fingers and palms of young adults \|journal=Am. J. Surg. Pathol. \|volume=21 \|issue=12 \|pages=1433–42 \|date=December 1997 \|pmid=9414186 \|doi=10.1097/00000478-199712000-00005 \|url=}}</ref>

	==Microscopic==		==Microscopic==

Jensflorian: molecular

2020-09-10T08:25:03Z

molecular

← Older revision		Revision as of 08:25, 10 September 2020
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	*EMA +ve.		*EMA +ve.
	*CD34 ~65% +ve.<ref name=pmid15958848/>		*CD34 ~65% +ve.<ref name=pmid15958848/>

			==Molecular==
			*Frequent TRAF7 mut.<ref name="pmid28019650">{{cite journal \|vauthors=Klein CJ, Wu Y, Jentoft ME, Mer G, Spinner RJ, Dyck PJ, Dyck PJ, Mauermann ML \|title=Genomic analysis reveals frequent TRAF7 mutations in intraneural perineuriomas \|journal=Ann. Neurol. \|volume=81 \|issue=2 \|pages=316–321 \|date=February 2017 \|pmid=28019650 \|pmc=5725965 \|doi=10.1002/ana.24854 \|url=}}</ref>

	==See also==		==See also==

Jensflorian: /* Microscopic */ typo

2018-08-30T07:10:04Z

Microscopic: typo

← Older revision		Revision as of 07:10, 30 August 2018
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	<gallery>		<gallery>
	File:Perineurioma,_HE_stain.jpg \| Pseudo-onion bulbs in a intraneural ~~perioneurioma~~ (WC/jensflorian)		File:Perineurioma,_HE_stain.jpg \| Pseudo-onion bulbs in a intraneural perineurioma (WC/jensflorian)
	</gallery>		</gallery>

Michael: /* See also */

2018-08-29T14:19:05Z

Michael: split out

2018-08-29T14:17:50Z

split out

← Older revision		Revision as of 14:17, 29 August 2018
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	~~#redirect~~ [[~~Peripheral_nerve_sheath_tumours#~~Perineurioma]]		'''Perineurioma''' is an uncommon benign [[peripheral nerve sheath tumour]].

			==General==
			*Benign tumour derived from perineurial cells (intraneural or soft tissue).
			**ICD-O 9571/0
			** WHO grade I
			*Rarely malignant soft tissue perineurioma.

			Variant:
			*Reticular perineurioma.<ref name=pmid11257623>{{Cite journal \| last1 = Graadt van Roggen \| first1 = JF. \| last2 = McMenamin \| first2 = ME. \| last3 = Belchis \| first3 = DA. \| last4 = Nielsen \| first4 = GP. \| last5 = Rosenberg \| first5 = AE. \| last6 = Fletcher \| first6 = CD. \| title = Reticular perineurioma: a distinctive variant of soft tissue perineurioma. \| journal = Am J Surg Pathol \| volume = 25 \| issue = 4 \| pages = 485-93 \| month = Apr \| year = 2001 \| doi = \| PMID = 11257623 }}</ref>

			==Macroscopy==
			*Intraneural perineurioma: segmental tubular enlargement of the nerve.
			*Soft tissue perineurioma: Well circumscribed, but not encapsulated.

			==Microscopic==
			Features:<ref name=Ref_Sternberg5_424>{{Ref Sternberg5\|424}}</ref>
			*Perineural epithelioid cells.
			**Abundant pale, fluffy appearing cytoplasm.

			Note:
			*May be intraneural.<ref name=Ref_Sternberg5_424>{{Ref Sternberg5\|424}}</ref>
			**Typical pseudo-onion bulbs.
			**Long considered hypertrophic neuropathy.
			**Rare (less than 1% of all nerve sheath tumours).

			DDx:
			*[[Neuroma]].
			*[[Neurofibroma]].
			*[[Schwannoma]].
			**S100 +ve, EMA -ve.<ref name=Ref_Sternberg5_424>{{Ref Sternberg5\|424}}</ref>
			*[[Liposarcoma]] - reticular perineurioma.

			Images:
			*[http://www.conganat.org/seap/reuniones/almagro2000/scruz/tnerviog5.htm Perineurioma (conganat.org)].

			<gallery>
			File:Perineurioma,_HE_stain.jpg \| Pseudo-onion bulbs in a intraneural perioneurioma (WC/jensflorian)
			</gallery>

			==IHC==
			Features:<ref name=pmid15958848>{{Cite journal \| last1 = Hornick \| first1 = JL. \| last2 = Fletcher \| first2 = CD. \| title = Soft tissue perineurioma: clinicopathologic analysis of 81 cases including those with atypical histologic features. \| journal = Am J Surg Pathol \| volume = 29 \| issue = 7 \| pages = 845-58 \| month = Jul \| year = 2005 \| doi = \| PMID = 15958848 }}</ref><ref name=pmid1497116>{{Cite journal \| last1 = Tsang \| first1 = WY. \| last2 = Chan \| first2 = JK. \| last3 = Chow \| first3 = LT. \| last4 = Tse \| first4 = CC. \| title = Perineurioma: an uncommon soft tissue neoplasm distinct from localized hypertrophic neuropathy and neurofibroma. \| journal = Am J Surg Pathol \| volume = 16 \| issue = 8 \| pages = 756-63 \| month = Aug \| year = 1992 \| doi = \| PMID = 1497116 }}</ref>
			*S100 -ve.
			*EMA +ve.
			*CD34 ~65% +ve.<ref name=pmid15958848/>

			==See also==
			*[[Peripheral nerve sheath tumours]].

			==References==
			{{Reflist\|1}}


	[[Category:Diagnosis]]		[[Category:Diagnosis]]
	[[Category:Neuropathology tumours]]		[[Category:Neuropathology tumours]]
	[[Category:Peripheral nerve sheath tumours]]		[[Category:Peripheral nerve sheath tumours]]

Jensflorian at 08:23, 14 December 2015

2015-12-14T08:23:08Z

← Older revision		Revision as of 08:23, 14 December 2015
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	[[Category:Diagnosis]]		[[Category:Diagnosis]]
	[[Category:Neuropathology tumours]]		[[Category:Neuropathology tumours]]
			[[Category:Peripheral nerve sheath tumours]]

Jensflorian at 08:21, 14 December 2015

2015-12-14T08:21:07Z

← Older revision		Revision as of 08:21, 14 December 2015
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	[[Category:Diagnosis]]		[[Category:Diagnosis]]
			[[Category:Neuropathology tumours]]

Michael: +cat.

2011-10-18T03:52:21Z

+cat.

← Older revision		Revision as of 03:52, 18 October 2011
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	#redirect [[Peripheral_nerve_sheath_tumours#Perineurioma]]		#redirect [[Peripheral_nerve_sheath_tumours#Perineurioma]]

			[[Category:Diagnosis]]

Michael: redirect for now

2011-05-13T05:54:42Z

redirect for now

New page

#redirect [[Peripheral_nerve_sheath_tumours#Perineurioma]]

← Older revision		Revision as of 14:19, 29 August 2018
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	==See also==		==See also==
	*[[Peripheral nerve sheath tumours]].		*[[Peripheral nerve sheath tumours]].
			*[[Hyperplastic polyp with perineuromatous stroma]].

	==References==		==References==