Primitive neuroectodermal tumour - Revision history

Jensflorian: /* CNS neuroblastoma */ molecular cluster

2017-10-04T13:44:56Z

CNS neuroblastoma: molecular cluster

← Older revision		Revision as of 13:44, 4 October 2017
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	===CNS neuroblastoma===		===CNS neuroblastoma===
	* ~~This~~ is now a subgroup of [[Other CNS embryonal tumours]].		* Since WHO 2016 CNS classification this is now a subgroup of [[Other CNS embryonal tumours]].
			* Many CNS neuroblastoma / CNS ganglioneuroblastoma cluster molecularly into a group designated as CNS NB-FOXR2.<ref>{{Cite journal \| last1 = Sturm \| first1 = D. \| last2 = Orr \| first2 = BA. \| last3 = Toprak \| first3 = UH. \| last4 = Hovestadt \| first4 = V. \| last5 = Jones \| first5 = DTW. \| last6 = Capper \| first6 = D. \| last7 = Sill \| first7 = M. \| last8 = Buchhalter \| first8 = I. \| last9 = Northcott \| first9 = PA. \| title = New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs. \| journal = Cell \| volume = 164 \| issue = 5 \| pages = 1060-1072 \| month = Feb \| year = 2016 \| doi = 10.1016/j.cell.2016.01.015 \| PMID = 26919435 }}</ref>
			*Usu Olig-2 +ve.
			*Synaptophysin +ve.

	===CNS ganglioneuroblastoma===		===CNS ganglioneuroblastoma===

Jensflorian: update

2017-10-04T13:33:24Z

update

← Older revision		Revision as of 13:33, 4 October 2017
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	===CNS neuroblastoma===		===CNS neuroblastoma===
			* This is now a subgroup of [[Other CNS embryonal tumours]].

	===CNS ganglioneuroblastoma===		===CNS ganglioneuroblastoma===
			* This is now a subgroup of [[Other CNS embryonal tumours]].

	===Lipomatous medulloblastoma===		===Lipomatous medulloblastoma===
			* These tumors are now designated as [[Cerebellar liponeurocytoma]].

			===Melanotic medulloblastoma===
			* In WHO CNS 1997 still a distinct tumor.
			* These tumors are now considered a variant of [[medulloblastoma]].

	===Medullomyoblastoma===		===Medullomyoblastoma===

Jensflorian: /* Medullomyoblastoma */ old tumor class

2017-10-04T13:26:22Z

Medullomyoblastoma: old tumor class

← Older revision		Revision as of 13:26, 4 October 2017
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	===Medullomyoblastoma===		===Medullomyoblastoma===
			* Embryonal tumor with primitive neuronal cells and striated muscle component.
			* First description in 1933.<ref>{{Cite journal \| last1 = Brody \| first1 = BS. \| last2 = German \| first2 = WJ. \| title = Medulloblastoma of the Cerebellum: A Report of 15 Cases. \| journal = Yale J Biol Med \| volume = 6 \| issue = 1 \| pages = 19-29 \| month = Oct \| year = 1933 \| doi = \| PMID = 21433586 }}</ref>
			* Since WHO 2007 CNS tumor classification tumors were classified as ''medulloblastoma with myogenic differentiation''.

	===Medulloepithelioma===		===Medulloepithelioma===

Jensflorian: now abandoned

2017-10-04T13:19:36Z

now abandoned

← Older revision		Revision as of 13:19, 4 October 2017
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	}}		}}

	''' CNS Primitive neuroectodermal tumour''', abbreviated '''CNS-PNET''', is an ~~uncommon~~ [[neuropathology tumour]] in the group of embryonal tumours.		''' CNS Primitive neuroectodermal tumour''', abbreviated '''CNS-PNET''', is an abandoned [[neuropathology tumour]] description within in the group of embryonal tumours.
			The terminology was introduced in 1973 <ref>{{Cite journal \| last1 = Hart \| first1 = MN. \| last2 = Earle \| first2 = KM. \| title = Primitive neuroectodermal tumors of the brain in children. \| journal = Cancer \| volume = 32 \| issue = 4 \| pages = 890-7 \| month = Oct \| year = 1973 \| doi = \| PMID = 4751919 }}</ref> and used in the WHO 2007 classification of CNS tumors. Since 2016 this category has been replaced by the designation '''other CNS embryonal tumors'''.
	~~It is also known as~~ '' ~~supratentorial primitive neuroepithelial tumour~~'' ~~(supratentorial PNET)~~.

	==General==		==General==
	*Should '''not''' be confused with ''peripheral primitive neuroectodermal tumour'' (abbreviated ''[[pPNET]]''<ref name=PST14feb11>PST. 14 February 2011.</ref>), [[AKA]] ''[[Ewing sarcoma]]''.		*Should '''not''' be confused with ''peripheral primitive neuroectodermal tumour'' (abbreviated ''[[pPNET]]''<ref name=PST14feb11>PST. 14 February 2011.</ref>), [[AKA]] ''[[Ewing sarcoma]]''.
	*~~Currently contains~~ a heterogenous group of poorly differentiated WHO grade IV tumours~~. '''Major reoganisation of this group will occur in the upcoming WHO classification.'''~~		*The former category contained a heterogenous group of poorly differentiated WHO grade IV tumours associated with following ICD-O codes:
	*Mainly children and adolescents.
	*Cerebral hemisphere, brain stem or spinal cord.
	*Cerebrospinal dissemination found in up to 1/3 patients.<ref name="pmid1030655">{{Cite journal \| last1 = Horten \| first1 = BC. \| last2 = Rubinstein \| first2 = LJ. \| title = Primary cerebral neuroblastoma. A clinicopathological study of 35 cases. \| journal = Brain \| volume = 99 \| issue = 4 \| pages = 735-56 \| month = Dec \| year = 1976 \| doi = \| PMID = 1030655 }}</ref>
	*There are currently five ICD-O codes ~~assigned within this group~~:
	**9473/3 CNS-PNET, NOS.		**9473/3 CNS-PNET, NOS.
	**9500/3 CNS neuroblastoma.		**9500/3 CNS neuroblastoma.
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	**9501/3 Medulloepithelioma.		**9501/3 Medulloepithelioma.
	**9392/3 Ependymoblastoma.		**9392/3 Ependymoblastoma.
			*Mainly children and adolescents.
			*Cerebral hemisphere, brain stem or spinal cord.
			*Cerebrospinal dissemination found in up to 1/3 patients.<ref name="pmid1030655">{{Cite journal \| last1 = Horten \| first1 = BC. \| last2 = Rubinstein \| first2 = LJ. \| title = Primary cerebral neuroblastoma. A clinicopathological study of 35 cases. \| journal = Brain \| volume = 99 \| issue = 4 \| pages = 735-56 \| month = Dec \| year = 1976 \| doi = \| PMID = 1030655 }}</ref>

	* Very poor prognosis<ref name="pmid26304823">{{Cite journal \| last1 = Tulla \| first1 = M. \| last2 = Berthold \| first2 = F. \| last3 = Graf \| first3 = N. \| last4 = Rutkowski \| first4 = S. \| last5 = von Schweinitz \| first5 = D. \| last6 = Spix \| first6 = C. \| last7 = Kaatsch \| first7 = P. \| title = Incidence, Trends, and Survival of Children With Embryonal Tumors. \| journal = Pediatrics \| volume = 136 \| issue = 3 \| pages = e623-32 \| month = Sep \| year = 2015 \| doi = 10.1542/peds.2015-0224 \| PMID = 26304823 }}</ref>		* Very poor prognosis<ref name="pmid26304823">{{Cite journal \| last1 = Tulla \| first1 = M. \| last2 = Berthold \| first2 = F. \| last3 = Graf \| first3 = N. \| last4 = Rutkowski \| first4 = S. \| last5 = von Schweinitz \| first5 = D. \| last6 = Spix \| first6 = C. \| last7 = Kaatsch \| first7 = P. \| title = Incidence, Trends, and Survival of Children With Embryonal Tumors. \| journal = Pediatrics \| volume = 136 \| issue = 3 \| pages = e623-32 \| month = Sep \| year = 2015 \| doi = 10.1542/peds.2015-0224 \| PMID = 26304823 }}</ref>

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	*Fibrillary background in tumours with advanced neuronal maturation (ganglioneuroblastomas).		*Fibrillary background in tumours with advanced neuronal maturation (ganglioneuroblastomas).
	*Variable mitotic activity.		*Variable mitotic activity.

			===Supratentorial PNET===
			* This category of small round- and blue cell tumor was used in the WHO 2007 CNS tumor classification to separate them from medulloblastomas.
			* Tumors are today classified as [[AT/RT]], [[Pineoblastoma]], [[ETMR]], H3F3A-mutated [[glioblastoma]] or CNS embryonal tumor, NOS.

			===CNS neuroblastoma===

			===CNS ganglioneuroblastoma===

			===Lipomatous medulloblastoma===

			===Medullomyoblastoma===

	===Medulloepithelioma===		===Medulloepithelioma===

Jensflorian: update + images

2015-10-09T09:07:19Z

update + images

← Older revision		Revision as of 09:07, 9 October 2015
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	==General==		==General==
	*Should '''not''' be confused with ''peripheral primitive neuroectodermal tumour'' (abbreviated ''[[pPNET]]''<ref name=PST14feb11>PST. 14 February 2011.</ref>), [[AKA]] ''[[Ewing sarcoma]]''.		*Should '''not''' be confused with ''peripheral primitive neuroectodermal tumour'' (abbreviated ''[[pPNET]]''<ref name=PST14feb11>PST. 14 February 2011.</ref>), [[AKA]] ''[[Ewing sarcoma]]''.
	*Currently contains a heterogenous group of poorly differentiated WHO grade IV tumours. Major reoganisation of this group will occur in the upcoming WHO classification.		*Currently contains a heterogenous group of poorly differentiated WHO grade IV tumours. '''Major reoganisation of this group will occur in the upcoming WHO classification.'''
	*Mainly children and adolescents.		*Mainly children and adolescents.
	*Cerebral hemisphere, brain stem or spinal cord.		*Cerebral hemisphere, brain stem or spinal cord.
			*Cerebrospinal dissemination found in up to 1/3 patients.<ref name="pmid1030655">{{Cite journal \| last1 = Horten \| first1 = BC. \| last2 = Rubinstein \| first2 = LJ. \| title = Primary cerebral neuroblastoma. A clinicopathological study of 35 cases. \| journal = Brain \| volume = 99 \| issue = 4 \| pages = 735-56 \| month = Dec \| year = 1976 \| doi = \| PMID = 1030655 }}</ref>
	*There are currently five ICD-O codes assigned within this group:		*There are currently five ICD-O codes assigned within this group:
	**9473/3 CNS-PNET, NOS.		**9473/3 CNS-PNET, NOS.
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	**9501/3 Medulloepithelioma.		**9501/3 Medulloepithelioma.
	**9392/3 Ependymoblastoma.		**9392/3 Ependymoblastoma.
			* Very poor prognosis<ref name="pmid26304823">{{Cite journal \| last1 = Tulla \| first1 = M. \| last2 = Berthold \| first2 = F. \| last3 = Graf \| first3 = N. \| last4 = Rutkowski \| first4 = S. \| last5 = von Schweinitz \| first5 = D. \| last6 = Spix \| first6 = C. \| last7 = Kaatsch \| first7 = P. \| title = Incidence, Trends, and Survival of Children With Embryonal Tumors. \| journal = Pediatrics \| volume = 136 \| issue = 3 \| pages = e623-32 \| month = Sep \| year = 2015 \| doi = 10.1542/peds.2015-0224 \| PMID = 26304823 }}</ref>

	==Microscopic==		==Microscopic==
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	*[[Small round blue cell tumour]].		*[[Small round blue cell tumour]].
	** Focal differentation into astrocytic, neuronal or ependymal phenotypes possible.		** Focal differentation into astrocytic, neuronal or ependymal phenotypes possible.
			*May have true rosettes (slit-like/oval).
			*Growth in streams or palisades possible ("spongioneuroblastoma").
			*Vascular endothelial proliferations.
			*Fibrillary background in tumours with advanced neuronal maturation (ganglioneuroblastomas).
			*Variable mitotic activity.

	==~~Immunohistocehmistry~~==		===Medulloepithelioma===
			*Neuroepithelial tumor cells arranged papillary, tubular or trabecular.
			*Pseudostratified with PAS-positive membrane.
			*Medulloepithelioma are grouped with ependymoblastomas and [[ETANTR]] into embryonal tumors with multilayered rosettes ([[ETMR]]).<ref name="pmid26438544">{{Cite journal \| last1 = Horwitz \| first1 = M. \| last2 = Dufour \| first2 = C. \| last3 = Leblond \| first3 = P. \| last4 = Bourdeaut \| first4 = F. \| last5 = Faure-Conter \| first5 = C. \| last6 = Bertozzi \| first6 = AI. \| last7 = Delisle \| first7 = MB. \| last8 = Palenzuela \| first8 = G. \| last9 = Jouvet \| first9 = A. \| title = Embryonal tumors with multilayered rosettes in children: the SFCE experience. \| journal = Childs Nerv Syst \| volume = \| issue = \| pages = \| month = Oct \| year = 2015 \| doi = 10.1007/s00381-015-2920-2 \| PMID = 26438544 }}</ref>
			*'''Not''' the same tumour as the intraocular medulloepithelioma.<ref name="pmid26183384">{{Cite journal \| last1 = Korshunov \| first1 = A. \| last2 = Jakobiec \| first2 = FA. \| last3 = Eberhart \| first3 = CG. \| last4 = Hovestadt \| first4 = V. \| last5 = Capper \| first5 = D. \| last6 = Jones \| first6 = DT. \| last7 = Sturm \| first7 = D. \| last8 = Stagner \| first8 = AM. \| last9 = Edward \| first9 = DP. \| title = Comparative integrated molecular analysis of intraocular medulloepitheliomas and central nervous system embryonal tumors with multilayered rosettes confirms that they are distinct nosologic entities. \| journal = Neuropathology \| volume = \| issue = \| pages = \| month = Jul \| year = 2015 \| doi = 10.1111/neup.12227 \| PMID = 26183384 }}</ref>

			<gallery>
			File:Medulloepithelioma_Histology.jpg \| Medulloepithelioma/ETMR ([[H&E]])
			File:Ependymoblastoma_ETMRjpg.jpg \| Medulloepithelioma/ETMR ([[H&E]])
			File:Medulloepitheliom_high.jpg \| Medulloepithelioma/ETMR ([[H&E]])
			</gallery>

			===Ependymoblastoma===
			*Often supratentorial, well circumscribed.
			*Multilayered ("ependymoblastous") rosettes.
			*High mitotic and proliferative activity
			*Ependymoblastoma are grouped with medulloepithelioma and [[ETANTR]] into embryonal tumors with multilayered rosettes ([[ETMR]]).<ref name="pmid26438544">{{Cite journal \| last1 = Horwitz \| first1 = M. \| last2 = Dufour \| first2 = C. \| last3 = Leblond \| first3 = P. \| last4 = Bourdeaut \| first4 = F. \| last5 = Faure-Conter \| first5 = C. \| last6 = Bertozzi \| first6 = AI. \| last7 = Delisle \| first7 = MB. \| last8 = Palenzuela \| first8 = G. \| last9 = Jouvet \| first9 = A. \| title = Embryonal tumors with multilayered rosettes in children: the SFCE experience. \| journal = Childs Nerv Syst \| volume = \| issue = \| pages = \| month = Oct \| year = 2015 \| doi = 10.1007/s00381-015-2920-2 \| PMID = 26438544 }}</ref>

			<gallery>
			File:Ependymoblastoma.jpg \| Ependymoblastoma. (WC/AFIP)
			File:Ependymoblastomatous_Rosette.jpg \| Ependymoblastous rosettes.
			File:MIB1_ependymoblastoma.jpg \| MIB-1 in ependymoblastous rosettes.
			</gallery>

			==Immunohistochemistry==
	* S-100 +ve.		* S-100 +ve.
	* INI1 +ve (loss defines tumour as [[ATRT]]).		* [[INI1]] +ve (loss defines tumour as [[ATRT]]).
			* [[LIN28]]+ve (in [[ETMR]]), otherwise -ve. <ref>{{Cite journal \| last1 = Korshunov \| first1 = A. \| last2 = Ryzhova \| first2 = M. \| last3 = Jones \| first3 = DT. \| last4 = Northcott \| first4 = PA. \| last5 = van Sluis \| first5 = P. \| last6 = Volckmann \| first6 = R. \| last7 = Koster \| first7 = J. \| last8 = Versteeg \| first8 = R. \| last9 = Cowdrey \| first9 = C. \| title = LIN28A immunoreactivity is a potent diagnostic marker of embryonal tumor with multilayered rosettes (ETMR). \| journal = Acta Neuropathol \| volume = 124 \| issue = 6 \| pages = 875-81 \| month = Dec \| year = 2012 \| doi = 10.1007/s00401-012-1068-3 \| PMID = 23161096 }}</ref>
			* Nestin +ve
			* [[MAP2]] +ve/-ve
			* Vimentin +ve
			* [[IDH-1]] -ve
			* No [[ATRX]] loss
			* MIB-1 between 20-80% (usu. 50%)

			==Molecular genetics==
			Divergent molecular subgroups are emerging:
			* Loss of 9q / CDKN2A deletions in CNS neuroblastoma<ref>{{Cite journal \| last1 = Pfister \| first1 = S. \| last2 = Remke \| first2 = M. \| last3 = Toedt \| first3 = G. \| last4 = Werft \| first4 = W. \| last5 = Benner \| first5 = A. \| last6 = Mendrzyk \| first6 = F. \| last7 = Wittmann \| first7 = A. \| last8 = Devens \| first8 = F. \| last9 = von Hoff \| first9 = K. \| title = Supratentorial primitive neuroectodermal tumors of the central nervous system frequently harbor deletions of the CDKN2A locus and other genomic aberrations distinct from medulloblastomas. \| journal = Genes Chromosomes Cancer \| volume = 46 \| issue = 9 \| pages = 839-51 \| month = Sep \| year = 2007 \| doi = 10.1002/gcc.20471 \| PMID = 17592618 }}</ref>
			*Amplification 19q13.42 in [[ETMR]]<ref>{{Cite journal \| last1 = Korshunov \| first1 = A. \| last2 = Remke \| first2 = M. \| last3 = Gessi \| first3 = M. \| last4 = Ryzhova \| first4 = M. \| last5 = Hielscher \| first5 = T. \| last6 = Witt \| first6 = H. \| last7 = Tobias \| first7 = V. \| last8 = Buccoliero \| first8 = AM. \| last9 = Sardi \| first9 = I. \| title = Focal genomic amplification at 19q13.42 comprises a powerful diagnostic marker for embryonal tumors with ependymoblastic rosettes. \| journal = Acta Neuropathol \| volume = 120 \| issue = 2 \| pages = 253-60 \| month = Aug \| year = 2010 \| doi = 10.1007/s00401-010-0688-8 \| PMID = 20407781 }}</ref>


	DDx:		DDx:
	* Small round blue cell tumours		* Small round blue cell tumours
	* [[Medulloblastoma]]		* [[Medulloblastoma]]
	* [[ATRT]]		* [[ATRT]] (INI1 loss)
	*[[Embryonal tumour with abundant neuropil and true rosettes]] (ETANTR).<ref name=pmid19563506>{{cite journal \|author=Buccoliero AM, Castiglione F, Degl'Innocenti DR, ''et al.'' \|title=Embryonal tumor with abundant neuropil and true rosettes: morphological, immunohistochemical, ultrastructural and molecular study of a case showing features of medulloepithelioma and areas of mesenchymal and epithelial differentiation \|journal=Neuropathology \|volume=30 \|issue=1 \|pages=84–91 \|year=2010 \|month=February \|pmid=19563506 \|doi=10.1111/j.1440-1789.2009.01040.x \|url=}}</ref>		* Anaplastic [[ependymoma]] (RELA fusions)
			* Paediatric [[glioblastoma]] (IDH1/2) and (H3F3A mutations)
			*[[Embryonal tumour with abundant neuropil and true rosettes]] (ETANTR) - currently no distinct WHO entity.<ref name=pmid19563506>{{cite journal \|author=Buccoliero AM, Castiglione F, Degl'Innocenti DR, ''et al.'' \|title=Embryonal tumor with abundant neuropil and true rosettes: morphological, immunohistochemical, ultrastructural and molecular study of a case showing features of medulloepithelioma and areas of mesenchymal and epithelial differentiation \|journal=Neuropathology \|volume=30 \|issue=1 \|pages=84–91 \|year=2010 \|month=February \|pmid=19563506 \|doi=10.1111/j.1440-1789.2009.01040.x \|url=}}</ref>

	===Images===		===Images===

Jensflorian: infobox

2015-10-09T06:35:42Z

infobox

← Older revision		Revision as of 06:35, 9 October 2015
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	~~'''Primitive_neuroectodermal_tumour''', abbreviated '''~~PNET~~''', is an uncommon~~ [[~~neuropathology tumour~~]].		{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image = PNET_Histopathology_HE_200x.jpg
			\| Width =
			\| Caption = CNS primitive neuroectodermal tumour [[H&E stain]].
			\| Synonyms = CNS-PNET
			\| Micro =
			\| Subtypes =
			\| LMDDx = [[small round blue cell tumours]]
			\| Stains =
			\| IHC = S-100 +ve, Syn +/-ve
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross =
			\| Grossing =
			\| Site = brain, spinal cord
			\| Assdx =
			\| Syndromes =
			\| Clinicalhx =
			\| Signs =
			\| Symptoms =
			\| Prevalence = rare - typically in young adults
			\| Bloodwork =
			\| Rads =
			\| Endoscopy =
			\| Prognosis = poor (WHO Grade IV)
			\| Other =
			\| ClinDDx =
			\| Tx =
			}}

	It is also known as ''primitive neuroepithelial tumour''. (~~???~~)		''' CNS Primitive neuroectodermal tumour''', abbreviated '''CNS-PNET''', is an uncommon [[neuropathology tumour]] in the group of embryonal tumours.

			It is also known as '' supratentorial primitive neuroepithelial tumour'' (supratentorial PNET).

	==General==		==General==
	*Should '''not''' be confused with ''peripheral primitive neuroectodermal tumour'' (abbreviated ''[[pPNET]]''<ref name=PST14feb11>PST. 14 February 2011.</ref>), [[AKA]] ''[[Ewing sarcoma]]''.		*Should '''not''' be confused with ''peripheral primitive neuroectodermal tumour'' (abbreviated ''[[pPNET]]''<ref name=PST14feb11>PST. 14 February 2011.</ref>), [[AKA]] ''[[Ewing sarcoma]]''.
			*Currently contains a heterogenous group of poorly differentiated WHO grade IV tumours. Major reoganisation of this group will occur in the upcoming WHO classification.
			*Mainly children and adolescents.
			*Cerebral hemisphere, brain stem or spinal cord.
			*There are currently five ICD-O codes assigned within this group:
			**9473/3 CNS-PNET, NOS.
			**9500/3 CNS neuroblastoma.
			**9490/3 CNS ganglioneuroblastoma.
			**9501/3 Medulloepithelioma.
			**9392/3 Ependymoblastoma.

	==Microscopic==		==Microscopic==
	Features:		Features:
	*[[Small round blue cell tumour]] - ~~see ''~~[[~~medulloblastoma~~]]''.		*[[Small round blue cell tumour]].
			** Focal differentation into astrocytic, neuronal or ependymal phenotypes possible.

			==Immunohistocehmistry==
			* S-100 +ve.
			* INI1 +ve (loss defines tumour as [[ATRT]]).

	DDx:		DDx:
			* Small round blue cell tumours
			* [[Medulloblastoma]]
			* [[ATRT]]
	*[[Embryonal tumour with abundant neuropil and true rosettes]] (ETANTR).<ref name=pmid19563506>{{cite journal \|author=Buccoliero AM, Castiglione F, Degl'Innocenti DR, ''et al.'' \|title=Embryonal tumor with abundant neuropil and true rosettes: morphological, immunohistochemical, ultrastructural and molecular study of a case showing features of medulloepithelioma and areas of mesenchymal and epithelial differentiation \|journal=Neuropathology \|volume=30 \|issue=1 \|pages=84–91 \|year=2010 \|month=February \|pmid=19563506 \|doi=10.1111/j.1440-1789.2009.01040.x \|url=}}</ref>		*[[Embryonal tumour with abundant neuropil and true rosettes]] (ETANTR).<ref name=pmid19563506>{{cite journal \|author=Buccoliero AM, Castiglione F, Degl'Innocenti DR, ''et al.'' \|title=Embryonal tumor with abundant neuropil and true rosettes: morphological, immunohistochemical, ultrastructural and molecular study of a case showing features of medulloepithelioma and areas of mesenchymal and epithelial differentiation \|journal=Neuropathology \|volume=30 \|issue=1 \|pages=84–91 \|year=2010 \|month=February \|pmid=19563506 \|doi=10.1111/j.1440-1789.2009.01040.x \|url=}}</ref>

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	[[Category:Neuropathology tumours]]		[[Category:Neuropathology tumours]]
			[[Category:Embryonal tumour]]
			[[Category:WHO Grade IV tumour]]

Michael: split out

2014-12-10T07:42:04Z

split out

← Older revision		Revision as of 07:42, 10 December 2014
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	~~#redirect~~ [[~~Neuropathology_tumours#Primitive_neuroectodermal_tumour~~]]		'''Primitive_neuroectodermal_tumour''', abbreviated '''PNET''', is an uncommon [[neuropathology tumour]].

			It is also known as ''primitive neuroepithelial tumour''. (???)

			==General==
			*Should '''not''' be confused with ''peripheral primitive neuroectodermal tumour'' (abbreviated ''[[pPNET]]''<ref name=PST14feb11>PST. 14 February 2011.</ref>), [[AKA]] ''[[Ewing sarcoma]]''.

			==Microscopic==
			Features:
			*[[Small round blue cell tumour]] - see ''[[medulloblastoma]]''.

			DDx:
			*[[Embryonal tumour with abundant neuropil and true rosettes]] (ETANTR).<ref name=pmid19563506>{{cite journal \|author=Buccoliero AM, Castiglione F, Degl'Innocenti DR, ''et al.'' \|title=Embryonal tumor with abundant neuropil and true rosettes: morphological, immunohistochemical, ultrastructural and molecular study of a case showing features of medulloepithelioma and areas of mesenchymal and epithelial differentiation \|journal=Neuropathology \|volume=30 \|issue=1 \|pages=84–91 \|year=2010 \|month=February \|pmid=19563506 \|doi=10.1111/j.1440-1789.2009.01040.x \|url=}}</ref>

			===Images===
			www:
			*[http://path.upmc.edu/cases/case414.html Primitive neuroectodermal tumour - several images (upmc.edu)].
			*[http://path.upmc.edu/cases/case649.html GBM with PNET component - several images (upmc.edu)].

			==See also==
			*[[Neuropathology tumours]].

			==References==
			{{Reflist\|2}}

			[[Category:Neuropathology tumours]]

Michael: create

2011-07-29T04:21:38Z

create

New page

#redirect [[Neuropathology_tumours#Primitive_neuroectodermal_tumour]]