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2015-10-14T15:07:59Z

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	[[Category:Immunohistochemistry]]		[[Category:Immunohistochemistry]]
			[[Category:Neuropathology]]

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2015-09-23T08:03:25Z

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{{ Infobox immunostain
| Name = {{PAGENAME}}
| Image = Neuropathology case VI 01.jpg
| Width =
| Caption = STAT6+ve in [[Hemangiopericytoma]].
| Abbrev =
| Synonyms =
| Similar =
| Clones =
| Use =
| Subspecial =
| Pattern = cytoplasmic staining (nuclear is diagnostic)
| Positive = [[Hemangiopericytoma]], [[SFT]]
| Negative = any healthy tissue
| Other =
}}
'''Signal transducer and activator of transcription 6''', commonly abbreviated '''STAT6''' is a diagnostic [[immunostain]], because nuclear staining is found in some specific types of cancer that carry a NAB2-STAT6 fusion <ref>{{Cite journal | last1 = Schweizer | first1 = L. | last2 = Koelsche | first2 = C. | last3 = Sahm | first3 = F. | last4 = Piro | first4 = RM. | last5 = Capper | first5 = D. | last6 = Reuss | first6 = DE. | last7 = Pusch | first7 = S. | last8 = Habel | first8 = A. | last9 = Meyer | first9 = J. | title = Meningeal hemangiopericytoma and solitary fibrous tumors carry the NAB2-STAT6 fusion and can be diagnosed by nuclear expression of STAT6 protein. | journal = Acta Neuropathol | volume = 125 | issue = 5 | pages = 651-8 | month = May | year = 2013 | doi = 10.1007/s00401-013-1117-6 | PMID = 23575898 }}</ref> or have a STAT6 amplification.<ref>{{Cite journal | last1 = Doyle | first1 = LA. | last2 = Tao | first2 = D. | last3 = Mariño-Enríquez | first3 = A. | title = STAT6 is amplified in a subset of dedifferentiated liposarcoma. | journal = Mod Pathol | volume = 27 | issue = 9 | pages = 1231-7 | month = Sep | year = 2014 | doi = 10.1038/modpathol.2013.247 | PMID = 24457460 }}</ref>

Cytoplasmic STAT6 staining is seen in a wide variety of tissue and represents normal protein localization.

==Positive==
* [[Hemangiopericytoma]].
* [[Solitary fibrous tumour]].<ref>{{Cite journal | last1 = Cheah | first1 = AL. | last2 = Billings | first2 = SD. | last3 = Goldblum | first3 = JR. | last4 = Carver | first4 = P. | last5 = Tanas | first5 = MZ. | last6 = Rubin | first6 = BP. | title = STAT6 rabbit monoclonal antibody is a robust diagnostic tool for the distinction of solitary fibrous tumour from its mimics. | journal = Pathology | volume = 46 | issue = 5 | pages = 389-95 | month = Aug | year = 2014 | doi = 10.1097/PAT.0000000000000122 | PMID = 24977739 }}</ref>
* well-differentiated/dedifferentiated [[liposarcoma]].<ref>{{Cite journal | last1 = Demicco | first1 = EG. | last2 = Harms | first2 = PW. | last3 = Patel | first3 = RM. | last4 = Smith | first4 = SC. | last5 = Ingram | first5 = D. | last6 = Torres | first6 = K. | last7 = Carskadon | first7 = SL. | last8 = Camelo-Piragua | first8 = S. | last9 = McHugh | first9 = JB. | title = Extensive survey of STAT6 expression in a large series of mesenchymal tumors. | journal = Am J Clin Pathol | volume = 143 | issue = 5 | pages = 672-82 | month = May | year = 2015 | doi = 10.1309/AJCPN25NJTOUNPNF | PMID = 25873501 }}</ref>

==See also==
*[[Immunohistochemistry]].

==References==
{{Reflist|1}}

[[Category:Immunohistochemistry]]

STAT6 - Revision history

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