Squamous metaplasia of the uterine cervix - Revision history

Michael: /* Microscopic */ remove deadlink

2015-09-17T15:17:49Z

Microscopic: remove deadlink

← Older revision		Revision as of 15:17, 17 September 2015
Line 74:		Line 74:
	*[http://commons.wikimedia.org/wiki/File:Bronchial_squamous_metaplasia.jpg Squamous metaplasia - bronchus (WC)].		*[http://commons.wikimedia.org/wiki/File:Bronchial_squamous_metaplasia.jpg Squamous metaplasia - bronchus (WC)].
	*[http://nih.techriver.net/patientImages%5C6676.jpg Squamous metaplasia - cytology (techriver.net)].<ref>URL: [http://nih.techriver.net/view.php?patientId=1 http://nih.techriver.net/view.php?patientId=1]. Accessed on: 17 September 2015.</ref>		*[http://nih.techriver.net/patientImages%5C6676.jpg Squamous metaplasia - cytology (techriver.net)].<ref>URL: [http://nih.techriver.net/view.php?patientId=1 http://nih.techriver.net/view.php?patientId=1]. Accessed on: 17 September 2015.</ref>
	*[http://www.eurocytology.eu/static/eurocytology/eng/cervical/mod1img4b.html Immature squamous metaplasia (eurocytology.eu)].<ref>URL: [http://www.eurocytology.eu/static/eurocytology/eng/cervical/LP1ContentAcontD.html http://www.eurocytology.eu/static/eurocytology/eng/cervical/LP1ContentAcontD.html]. Accessed on: 9 October 2013.</ref>

	==IHC==		==IHC==

Michael: /* Images */

2015-09-17T15:16:50Z

Images

← Older revision		Revision as of 15:16, 17 September 2015
Line 73:		Line 73:
	*[http://www.sciencephoto.com/media/294722/view Squamous metaplasia - cervix (sciencephoto.com)].		*[http://www.sciencephoto.com/media/294722/view Squamous metaplasia - cervix (sciencephoto.com)].
	*[http://commons.wikimedia.org/wiki/File:Bronchial_squamous_metaplasia.jpg Squamous metaplasia - bronchus (WC)].		*[http://commons.wikimedia.org/wiki/File:Bronchial_squamous_metaplasia.jpg Squamous metaplasia - bronchus (WC)].
	*[http://nih.techriver.net/patientImages%5C6676.jpg Squamous metaplasia - cytology (techriver.net)].		*[http://nih.techriver.net/patientImages%5C6676.jpg Squamous metaplasia - cytology (techriver.net)].<ref>URL: [http://nih.techriver.net/view.php?patientId=1 http://nih.techriver.net/view.php?patientId=1]. Accessed on: 17 September 2015.</ref>
	*[http://www.eurocytology.eu/static/eurocytology/eng/cervical/mod1img4b.html Immature squamous metaplasia (eurocytology.eu)].<ref>URL: [http://www.eurocytology.eu/static/eurocytology/eng/cervical/LP1ContentAcontD.html http://www.eurocytology.eu/static/eurocytology/eng/cervical/LP1ContentAcontD.html]. Accessed on: 9 October 2013.</ref>		*[http://www.eurocytology.eu/static/eurocytology/eng/cervical/mod1img4b.html Immature squamous metaplasia (eurocytology.eu)].<ref>URL: [http://www.eurocytology.eu/static/eurocytology/eng/cervical/LP1ContentAcontD.html http://www.eurocytology.eu/static/eurocytology/eng/cervical/LP1ContentAcontD.html]. Accessed on: 9 October 2013.</ref>

Michael: /* Images */

2014-05-06T02:06:10Z

Images

← Older revision		Revision as of 02:06, 6 May 2014
Line 66:		Line 66:

	===Images===		===Images===
			<gallery>
			Image: Endocervical epithelium and squamous metaplasia -- high mag.jpg \| Endocx and SM - high mag.
			Image: Endocervical epithelium and squamous metaplasia -- very high mag.jpg \| Endocx and SM - very high mag.
			</gallery>
			www:
	*[http://www.sciencephoto.com/media/294722/view Squamous metaplasia - cervix (sciencephoto.com)].		*[http://www.sciencephoto.com/media/294722/view Squamous metaplasia - cervix (sciencephoto.com)].
	*[http://commons.wikimedia.org/wiki/File:Bronchial_squamous_metaplasia.jpg Squamous metaplasia - bronchus (WC)].		*[http://commons.wikimedia.org/wiki/File:Bronchial_squamous_metaplasia.jpg Squamous metaplasia - bronchus (WC)].

Michael at 02:05, 6 May 2014

2014-05-06T02:05:00Z

← Older revision		Revision as of 02:05, 6 May 2014
Line 1:		Line 1:

			{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image = Endocervical_epithelium_and_squamous_metaplasia_--_very_high_mag.jpg
			\| Width =
			\| Caption = Squamous metaplasia and endocervical epithelium. [[H&E stain]].
			\| Synonyms =
			\| Micro = uniform cell spacing (no "crowding"), nuclei are uniform size and round, +/-[[nucleoli]], distinct cell borders +/- intercellular bridges visible (common), adjacent/closely associated with endocervical epithelium - classically sits on surface (immature metaplasia), mitoses - rare, usually no nuclear hyperchromasia
			\| Subtypes =
			\| LMDDx = [[HSIL]], [[reactive squamous epithelium of the uterine cervix]], [[squamous cell carcinoma of the uterine cervix]]
			\| Stains =
			\| IHC = p16 patchy +ve (''not'' diffuse), Ki-67 low & predominantly basal
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross =
			\| Grossing =
			\| Site = [[uterine cervix]]
			\| Assdx =
			\| Syndromes =
			\| Clinicalhx =
			\| Signs = [[acetowhite lesion]]
			\| Symptoms = none
			\| Prevalence = common
			\| Bloodwork =
			\| Rads =
			\| Endoscopy =
			\| Prognosis = benign
			\| Other =
			\| ClinDDx = [[squamous intraepithelial lesion of the uterine cervix]]
			\| Tx =
			}}
	'''Squamous metaplasia of the uterine cervix''' is a common change of the [[uterine cervix]] that may resemble [[squamous intraepithelial lesion]].		'''Squamous metaplasia of the uterine cervix''' is a common change of the [[uterine cervix]] that may resemble [[squamous intraepithelial lesion]].

Michael: split out

2014-05-06T01:54:43Z

split out

← Older revision		Revision as of 01:54, 6 May 2014
Line 1:		Line 1:
	~~#redirect~~ [[~~Uterine_cervix#Squamous_metaplasia_of_the_uterine_cervix~~]]		'''Squamous metaplasia of the uterine cervix''' is a common change of the [[uterine cervix]] that may resemble [[squamous intraepithelial lesion]].

	<!-- [[~~Category~~:~~Diagnosis~~]] -->		It may be abbreviated '''SMC'''.

			==General==
			*Benign process: columnar cells -> squamoid cells.
			**Biologic response to irritation and/or inflammation.

			==Gross==
			*[[Acetowhite epithelium\|Acetowhite lesion]].<ref name=pmid19256708>{{Cite journal \| last1 = Li \| first1 = W. \| last2 = Venkataraman \| first2 = S. \| last3 = Gustafsson \| first3 = U. \| last4 = Oyama \| first4 = JC. \| last5 = Ferris \| first5 = DG. \| last6 = Lieberman \| first6 = RW. \| title = Using acetowhite opacity index for detecting cervical intraepithelial neoplasia. \| journal = J Biomed Opt \| volume = 14 \| issue = 1 \| pages = 014020 \| month = \| year = \| doi = 10.1117/1.3079810 \| PMID = 19256708 }}</ref>

			==Microscopic==
			Features:
			* Uniform cell spacing - no crowding - '''key feature'''.
			* Nuclei are uniform size and round.
			** [[Nucleoli]] present.
			*Distinct cell borders
			* +/-Intercellular bridges (due to edema) - common.
			* Adjacent/closely associated with columnar epithelium.
			** Columnar epithelium superficial in immature metaplasia.

			Negatives:
			* No mitoses (think cancer/CIN if you see 'em).
			* Usually no hyperchromatism (think cancer/CIN if you see it).

			Notes:
			*NC ratio high - possible to confuse with CIN III.
			*May have goblet cells - uncommon.<ref name=pmid21077478>{{Cite journal \| last1 = Sivridis \| first1 = E. \| last2 = Karpathiou \| first2 = G. \| last3 = Malamou-Mitsi \| first3 = V. \| last4 = Giatromanolaki \| first4 = A. \| title = Intestinal-type metaplasia in the original squamous epithelium of the cervix. \| journal = Eur J Gynaecol Oncol \| volume = 31 \| issue = 3 \| pages = 319-22 \| month = \| year = 2010 \| doi = \| PMID = 21077478 }}</ref>

			DDx:
			*[[CIN II]] - esp. for immature squamous metaplasia.
			*[[CIN III]].
			*[[Squamous cell carcinoma of the uterine cervix]].

			===Images===
			*[http://www.sciencephoto.com/media/294722/view Squamous metaplasia - cervix (sciencephoto.com)].
			*[http://commons.wikimedia.org/wiki/File:Bronchial_squamous_metaplasia.jpg Squamous metaplasia - bronchus (WC)].
			*[http://nih.techriver.net/patientImages%5C6676.jpg Squamous metaplasia - cytology (techriver.net)].
			*[http://www.eurocytology.eu/static/eurocytology/eng/cervical/mod1img4b.html Immature squamous metaplasia (eurocytology.eu)].<ref>URL: [http://www.eurocytology.eu/static/eurocytology/eng/cervical/LP1ContentAcontD.html http://www.eurocytology.eu/static/eurocytology/eng/cervical/LP1ContentAcontD.html]. Accessed on: 9 October 2013.</ref>

			==IHC==
			*p16 weak-to-moderate patchy +ve -- checkerboard-like; not full thickness.
			**Strong diffuse full thickness positivity in HSIL and SCC.
			*Ki-67 - low proliferative rate.

			==Sign out==
			===ECC===
			<pre>
			UTERINE ENDOCERVIX, CURETTAGE:
			- SQUAMOUS METAPLASTIC EPITHELIUM.
			- VERY SCANT STRIPPED ENDOCERVICAL EPITHELIUM.
			</pre>

			===Cervical biopsy===
			<pre>
			UTERINE CERVIX, BIOPSY:
			- SQUAMOUS METAPLASTIC EPITHELIUM.
			- SCANT BENIGN ENDOCERVICAL GLANDS.
			</pre>

			<pre>
			UTERINE CERVIX, BIOPSY:
			- SQUAMOUS METAPLASTIC EPITHELIUM.
			- SCANT BENIGN ENDOCERVICAL GLANDS.
			- NEGATIVE FOR DYSPLASIA AND NEGATIVE FOR MALIGNANCY.
			</pre>

			===Micro===
			The sections show stratified squamous epithelium. The cells are equally spaced and spaces are seen between the cells (edema).

			The nuclei are not significantly enlarged (<3x resting lymphocyte diameter). No nuclear halos are apparent. The nuclear membranes are regular. Mild inflammation is present. Nucleoli are present focally.

			No endocervical cells are identified.

			==See also==
			*[[Squamous metaplasia]].
			*[[Uterine cervix]].

			==References==
			{{Reflist\|2}}

			[[Category:Uterine cervix]]
			[[Category:Diagnosis]]

Michael: create

2012-04-29T14:14:17Z

create

New page

#redirect [[Uterine_cervix#Squamous_metaplasia_of_the_uterine_cervix]]