Subependymoma - Revision history

Jensflorian: /* Molecular */ chr. 6

2020-07-08T14:00:16Z

Molecular: chr. 6

← Older revision		Revision as of 14:00, 8 July 2020
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	==Molecular==		==Molecular==
	*No consistent abberations		*Posterior fossa and spine: chr.6 alterations.
			*Supratentorial: No consistent abberations.

	==See also==		==See also==

Jensflorian: update + pictures from WC

2015-04-15T15:02:37Z

update + pictures from WC

← Older revision		Revision as of 15:02, 15 April 2015
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	==General==		==General==
	*Good prognosis - WHO Grade I.		*Good prognosis - WHO Grade I (ICD-O 9383/1).
	*Low-grade glial tumour.<ref name=pmid23483468/>		*Low-grade glial tumour of the middle-aged and elderly.<ref name=pmid23483468/>
			*Formerly called ''subependymal (glomerate) astrocytoma''

	Clinical:<ref name=pmid23483468>{{Cite journal \| last1 = Castro-Castro \| first1 = J. \| last2 = Castro-Bouzas \| first2 = D. \| last3 = Prieto-Casal \| first3 = PL. \| last4 = Carcacia-Hermilla \| first4 = ID. \| last5 = Riu-Lloveras \| first5 = M. \| last6 = Castro-Gómez \| first6 = JE. \| title = [Subependymoma of the lateral ventricle. A case report]. \| journal = Rev Neurol \| volume = 56 \| issue = 6 \| pages = 332-6 \| month = Mar \| year = 2013 \| doi = \| PMID = 23483468 }}		Clinical:<ref name=pmid23483468>{{Cite journal \| last1 = Castro-Castro \| first1 = J. \| last2 = Castro-Bouzas \| first2 = D. \| last3 = Prieto-Casal \| first3 = PL. \| last4 = Carcacia-Hermilla \| first4 = ID. \| last5 = Riu-Lloveras \| first5 = M. \| last6 = Castro-Gómez \| first6 = JE. \| title = [Subependymoma of the lateral ventricle. A case report]. \| journal = Rev Neurol \| volume = 56 \| issue = 6 \| pages = 332-6 \| month = Mar \| year = 2013 \| doi = \| PMID = 23483468 }}
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	*Slow growing.		*Slow growing.
	*+/-Headaches.		*+/-Headaches.
			*CSF obstructions.
	*Tx: surgery.		*Tx: surgery.

	==Gross/radiology==		==Gross/radiology==
	*Classic location: fourth ventricle.<ref>{{Cite journal \| last1 = Hoeffel \| first1 = C. \| last2 = Boukobza \| first2 = M. \| last3 = Polivka \| first3 = M. \| last4 = Lot \| first4 = G. \| last5 = Guichard \| first5 = JP. \| last6 = Lafitte \| first6 = F. \| last7 = Reizine \| first7 = D. \| last8 = Merland \| first8 = JJ. \| title = MR manifestations of subependymomas. \| journal = AJNR Am J Neuroradiol \| volume = 16 \| issue = 10 \| pages = 2121-9 \| month = \| year = \| doi = \| PMID = 8585504 \|url=http://www.ajnr.org/cgi/reprint/16/10/2121}}</ref>		*Classic location: fourth ventricle (50-60%).<ref>{{Cite journal \| last1 = Hoeffel \| first1 = C. \| last2 = Boukobza \| first2 = M. \| last3 = Polivka \| first3 = M. \| last4 = Lot \| first4 = G. \| last5 = Guichard \| first5 = JP. \| last6 = Lafitte \| first6 = F. \| last7 = Reizine \| first7 = D. \| last8 = Merland \| first8 = JJ. \| title = MR manifestations of subependymomas. \| journal = AJNR Am J Neuroradiol \| volume = 16 \| issue = 10 \| pages = 2121-9 \| month = \| year = \| doi = \| PMID = 8585504 \|url=http://www.ajnr.org/cgi/reprint/16/10/2121}}</ref>
			*Lateral ventricles (30-40% of all cases), rarely IIIrd ventricle, septum pellucideum and spinal cord
	*Well-demarcated margin.		*Well-demarcated margin.
	*Usu. completely within the ventricle; does not extend into brain (like [[ependymoma]]s).		*Usu. completely within the ventricle; does not extend into brain (like [[ependymoma]]s).
			*May be hemorrhagic. <ref>{{Cite journal \| last1 = Landriel \| first1 = F. \| last2 = Besada \| first2 = C. \| last3 = Migliaro \| first3 = M. \| last4 = Christiansen \| first4 = S. \| last5 = Goldschmidt \| first5 = E. \| last6 = Yampolsky \| first6 = C. \| last7 = Ajler \| first7 = P. \| title = Atypical hemorrhagic presentation of a fourth ventricle subependymoma: case report. \| journal = Neurol Med Chir (Tokyo) \| volume = 53 \| issue = 11 \| pages = 828-31 \| month = \| year = 2013 \| doi = \| PMID = 24140775 }}</ref>
			*Usually less than 2cm in diameter.
			*Incidentally found at autopsies.

			===Images===
			<gallery>
			File:AFIP405740R-SUBEPENDYMOMA.jpg \| Subependymoma (AFIP)
			File:Subependymoma.jpg \| Macroscopy (AFIP)
			</gallery>

	==Microscopic==		==Microscopic==
	Features:<ref name=ouhsc>URL: [http://moon.ouhsc.edu/kfung/jty1/Com05/Com501-2-Diss.htm http://moon.ouhsc.edu/kfung/jty1/Com05/Com501-2-Diss.htm]. Accessed on: 2 June 2011.</ref>		Features:<ref name=ouhsc>URL: [http://moon.ouhsc.edu/kfung/jty1/Com05/Com501-2-Diss.htm http://moon.ouhsc.edu/kfung/jty1/Com05/Com501-2-Diss.htm]. Accessed on: 2 June 2011.</ref>
	*Microcysts with bluish material - give a spongy appearance at low magnification.		*Microcysts with bluish material - give a spongy appearance at low magnification.
	*~~Nuclei~~ cluster.		*Isomorphic nuclei cluster embedded into fibrillary matrix.
	**Described as "bundles of flowers".		**Described as "bundles of flowers".
			*Calcifications possible
			*Combined subependymomas/classical cellular ependymomas (then grade II)

	Negatives.		Negatives.
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	===Images===		===Images===
	www:		www: [http://moon.ouhsc.edu/kfung/jty1/Com05/Com05Image/Com501-2-04.gif Subependymoma (ouhsc.edu)].<ref name=ouhsc>URL: [http://moon.ouhsc.edu/kfung/jty1/Com05/Com501-2-Diss.htm http://moon.ouhsc.edu/kfung/jty1/Com05/Com501-2-Diss.htm]. Accessed on: 2 June 2011.</ref>
	*[http://moon.ouhsc.edu/kfung/jty1/Com05/Com05Image/Com501-2-04.gif Subependymoma (ouhsc.edu)].<ref name=ouhsc>URL: [http://moon.ouhsc.edu/kfung/jty1/Com05/Com501-2-Diss.htm http://moon.ouhsc.edu/kfung/jty1/Com05/Com501-2-Diss.htm]. Accessed on: 2 June 2011.</ref>
	<gallery>		<gallery>
			File:Subependymoma HE x40.jpg \| Subependymoma - low mag. (WC/jensflorian)
	Image:Subependymoma_-_intermed_mag.jpg \| Subependyoma - intermed. mag. (WC)		Image:Subependymoma_-_intermed_mag.jpg \| Subependyoma - intermed. mag. (WC)
	Image:Subependymoma_-_high_mag.jpg \| Subependymoma - high mag. (WC)		Image:Subependymoma_-_high_mag.jpg \| Subependymoma - high mag. (WC)
			File:Subependymoma 2 - high mag.jpg \| Subependymoma - high mag. (WC/Nephron)
	Image:Subependymoma_-_very_high_mag.jpg \| Subependymoma - very high mag. (WC)		Image:Subependymoma_-_very_high_mag.jpg \| Subependymoma - very high mag. (WC)
			File:AFIP405743M-SUBEPENDYMOMA.jpg \| Subependymoma (AFIP)
	</gallery>		</gallery>

			DDx:
			[[Ependymoma]]

			==IHC==
			*GFAP+ve
			*MIB-1 very low (1%)
			*ATRX: no loss
			*IDH1(R132H)-ve

			==Molecular==
			*No consistent abberations

	==See also==		==See also==

Michael at 03:03, 17 February 2014

2014-02-17T03:03:49Z

← Older revision		Revision as of 03:03, 17 February 2014
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	\| Clinicalhx =		\| Clinicalhx =
	\| Signs =		\| Signs =
	\| Symptoms =		\| Symptoms = +/-headache
	\| Prevalence =		\| Prevalence =
	\| Bloodwork =		\| Bloodwork =
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	\| Other =		\| Other =
	\| ClinDDx = other brain tumours - [[ependymoma]], [[CNS lymphoma]]		\| ClinDDx = other brain tumours - [[ependymoma]], [[CNS lymphoma]]
	\| Tx =		\| Tx = surgical excision
	}}		}}
	'''Subependymoma''' is [[neuropathology]] tumour classically found in the fourth ventricle.		'''Subependymoma''' is [[neuropathology]] tumour classically found in the fourth ventricle.
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	==General==		==General==
	*Good prognosis - WHO Grade I.		*Good prognosis - WHO Grade I.
			*Low-grade glial tumour.<ref name=pmid23483468/>

			Clinical:<ref name=pmid23483468>{{Cite journal \| last1 = Castro-Castro \| first1 = J. \| last2 = Castro-Bouzas \| first2 = D. \| last3 = Prieto-Casal \| first3 = PL. \| last4 = Carcacia-Hermilla \| first4 = ID. \| last5 = Riu-Lloveras \| first5 = M. \| last6 = Castro-Gómez \| first6 = JE. \| title = [Subependymoma of the lateral ventricle. A case report]. \| journal = Rev Neurol \| volume = 56 \| issue = 6 \| pages = 332-6 \| month = Mar \| year = 2013 \| doi = \| PMID = 23483468 }}
			</ref>
			*Slow growing.
			*+/-Headaches.
			*Tx: surgery.

	==Gross/radiology==		==Gross/radiology==
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	Negatives.		Negatives.
	*No nuclear pleomorphism, no prominent nucleoli, no mitoses.		*No nuclear pleomorphism, no prominent nucleoli, no mitoses.
			*Do not invade into brain.<ref name=pmid23483468/>

	===Images===		===Images===

Michael: +infobox

2014-02-17T02:58:13Z

+infobox

← Older revision		Revision as of 02:58, 17 February 2014
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			{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image = Subependymoma_-_very_high_mag.jpg
			\| Width =
			\| Caption = Subependymoma. [[H&E stain]].
			\| Synonyms =
			\| Micro = microcysts with bluish material (give a spongy appearance at low magnification), clustering of nuclei cluster (described as "bundles of flowers"), bland nuclei
			\| Subtypes =
			\| LMDDx =
			\| Stains =
			\| IHC =
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross =
			\| Grossing =
			\| Site = [[brain]] - see ''[[neuropathology tumours]]''
			\| Assdx =
			\| Syndromes =
			\| Clinicalhx =
			\| Signs =
			\| Symptoms =
			\| Prevalence =
			\| Bloodwork =
			\| Rads = classically fourth ventricle
			\| Endoscopy =
			\| Prognosis = WHO grade I
			\| Other =
			\| ClinDDx = other brain tumours - [[ependymoma]], [[CNS lymphoma]]
			\| Tx =
			}}
	'''Subependymoma''' is [[neuropathology]] tumour classically found in the fourth ventricle.		'''Subependymoma''' is [[neuropathology]] tumour classically found in the fourth ventricle.

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	==Gross/radiology==		==Gross/radiology==
	*Classic location: fourth ventricle.<ref>{{Cite journal \| last1 = Hoeffel \| first1 = C. \| last2 = Boukobza \| first2 = M. \| last3 = Polivka \| first3 = M. \| last4 = Lot \| first4 = G. \| last5 = Guichard \| first5 = JP. \| last6 = Lafitte \| first6 = F. \| last7 = Reizine \| first7 = D. \| last8 = Merland \| first8 = JJ. \| title = MR manifestations of subependymomas. \| journal = AJNR Am J Neuroradiol \| volume = 16 \| issue = 10 \| pages = 2121-9 \| month = \| year = \| doi = \| PMID = 8585504 \|url=http://www.ajnr.org/cgi/reprint/16/10/2121}}</ref>		*Classic location: fourth ventricle.<ref>{{Cite journal \| last1 = Hoeffel \| first1 = C. \| last2 = Boukobza \| first2 = M. \| last3 = Polivka \| first3 = M. \| last4 = Lot \| first4 = G. \| last5 = Guichard \| first5 = JP. \| last6 = Lafitte \| first6 = F. \| last7 = Reizine \| first7 = D. \| last8 = Merland \| first8 = JJ. \| title = MR manifestations of subependymomas. \| journal = AJNR Am J Neuroradiol \| volume = 16 \| issue = 10 \| pages = 2121-9 \| month = \| year = \| doi = \| PMID = 8585504 \|url=http://www.ajnr.org/cgi/reprint/16/10/2121}}</ref>
	*Well demarcated margin.		*Well-demarcated margin.
	*Usu. completely within the ventricle; does not extend into brain (like [[ependymoma]]s).		*Usu. completely within the ventricle; does not extend into brain (like [[ependymoma]]s).

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	Image:Subependymoma_-_intermed_mag.jpg \| Subependyoma - intermed. mag. (WC)		Image:Subependymoma_-_intermed_mag.jpg \| Subependyoma - intermed. mag. (WC)
	Image:Subependymoma_-_high_mag.jpg \| Subependymoma - high mag. (WC)		Image:Subependymoma_-_high_mag.jpg \| Subependymoma - high mag. (WC)
			Image:Subependymoma_-_very_high_mag.jpg \| Subependymoma - very high mag. (WC)
	</gallery>		</gallery>

Michael: split out

2014-02-17T02:53:45Z

split out

← Older revision		Revision as of 02:53, 17 February 2014
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	~~#redirect~~ [[~~Neuropathology_tumours#~~Subependymoma]]		'''Subependymoma''' is [[neuropathology]] tumour classically found in the fourth ventricle.

			==General==
			*Good prognosis - WHO Grade I.

			==Gross/radiology==
			*Classic location: fourth ventricle.<ref>{{Cite journal \| last1 = Hoeffel \| first1 = C. \| last2 = Boukobza \| first2 = M. \| last3 = Polivka \| first3 = M. \| last4 = Lot \| first4 = G. \| last5 = Guichard \| first5 = JP. \| last6 = Lafitte \| first6 = F. \| last7 = Reizine \| first7 = D. \| last8 = Merland \| first8 = JJ. \| title = MR manifestations of subependymomas. \| journal = AJNR Am J Neuroradiol \| volume = 16 \| issue = 10 \| pages = 2121-9 \| month = \| year = \| doi = \| PMID = 8585504 \|url=http://www.ajnr.org/cgi/reprint/16/10/2121}}</ref>
			*Well demarcated margin.
			*Usu. completely within the ventricle; does not extend into brain (like [[ependymoma]]s).

			==Microscopic==
			Features:<ref name=ouhsc>URL: [http://moon.ouhsc.edu/kfung/jty1/Com05/Com501-2-Diss.htm http://moon.ouhsc.edu/kfung/jty1/Com05/Com501-2-Diss.htm]. Accessed on: 2 June 2011.</ref>
			*Microcysts with bluish material - give a spongy appearance at low magnification.
			*Nuclei cluster.
			**Described as "bundles of flowers".

			Negatives.
			*No nuclear pleomorphism, no prominent nucleoli, no mitoses.

			===Images===
			www:
			*[http://moon.ouhsc.edu/kfung/jty1/Com05/Com05Image/Com501-2-04.gif Subependymoma (ouhsc.edu)].<ref name=ouhsc>URL: [http://moon.ouhsc.edu/kfung/jty1/Com05/Com501-2-Diss.htm http://moon.ouhsc.edu/kfung/jty1/Com05/Com501-2-Diss.htm]. Accessed on: 2 June 2011.</ref>
			<gallery>
			Image:Subependymoma_-_intermed_mag.jpg \| Subependyoma - intermed. mag. (WC)
			Image:Subependymoma_-_high_mag.jpg \| Subependymoma - high mag. (WC)
			</gallery>

			==See also==
			*[[Neuropathology tumours]].
			*[[Neuropathology]].

			==References==
			{{Reflist\|2}}

	[[Category:Diagnosis]]		[[Category:Diagnosis]]
			[[Category:Neuropathology tumours]]

Michael: +cat.

2011-10-18T04:01:46Z

+cat.

← Older revision		Revision as of 04:01, 18 October 2011
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	#redirect [[Neuropathology_tumours#Subependymoma]]		#redirect [[Neuropathology_tumours#Subependymoma]]

			[[Category:Diagnosis]]

Michael: redirect

2011-06-02T14:29:28Z

redirect

New page

#redirect [[Neuropathology_tumours#Subependymoma]]