TDP-43 - Revision history

Jensflorian at 12:03, 5 July 2018

2018-07-05T12:03:33Z

← Older revision		Revision as of 12:03, 5 July 2018
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	* [[Alzheimer disease]].<ref>{{Cite journal \| last1 = Wilson \| first1 = AC. \| last2 = Dugger \| first2 = BN. \| last3 = Dickson \| first3 = DW. \| last4 = Wang \| first4 = DS. \| title = TDP-43 in aging and Alzheimer's disease - a review. \| journal = Int J Clin Exp Pathol \| volume = 4 \| issue = 2 \| pages = 147-55 \| month = Jan \| year = 2011 \| doi = \| PMID = 21326809 }}</ref>		* [[Alzheimer disease]].<ref>{{Cite journal \| last1 = Wilson \| first1 = AC. \| last2 = Dugger \| first2 = BN. \| last3 = Dickson \| first3 = DW. \| last4 = Wang \| first4 = DS. \| title = TDP-43 in aging and Alzheimer's disease - a review. \| journal = Int J Clin Exp Pathol \| volume = 4 \| issue = 2 \| pages = 147-55 \| month = Jan \| year = 2011 \| doi = \| PMID = 21326809 }}</ref>
	*[[Chronic traumatic encephalopathy]] (CTE).<ref>{{Cite journal \| last1 = McKee \| first1 = AC. \| last2 = Cairns \| first2 = NJ. \| last3 = Dickson \| first3 = DW. \| last4 = Folkerth \| first4 = RD. \| last5 = Keene \| first5 = CD. \| last6 = Litvan \| first6 = I. \| last7 = Perl \| first7 = DP. \| last8 = Stein \| first8 = TD. \| last9 = Vonsattel \| first9 = JP. \| title = The first NINDS/NIBIB consensus meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy. \| journal = Acta Neuropathol \| volume = 131 \| issue = 1 \| pages = 75-86 \| month = Jan \| year = 2016 \| doi = 10.1007/s00401-015-1515-z \| PMID = 26667418 }}</ref>		*[[Chronic traumatic encephalopathy]] (CTE).<ref>{{Cite journal \| last1 = McKee \| first1 = AC. \| last2 = Cairns \| first2 = NJ. \| last3 = Dickson \| first3 = DW. \| last4 = Folkerth \| first4 = RD. \| last5 = Keene \| first5 = CD. \| last6 = Litvan \| first6 = I. \| last7 = Perl \| first7 = DP. \| last8 = Stein \| first8 = TD. \| last9 = Vonsattel \| first9 = JP. \| title = The first NINDS/NIBIB consensus meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy. \| journal = Acta Neuropathol \| volume = 131 \| issue = 1 \| pages = 75-86 \| month = Jan \| year = 2016 \| doi = 10.1007/s00401-015-1515-z \| PMID = 26667418 }}</ref>
	*[[Lewy body disease]].<ref>{{Cite journal \| last1 = Ling \| first1 = H. \| last2 = Kara \| first2 = E. \| last3 = Bandopadhyay \| first3 = R. \| last4 = Hardy \| first4 = J. \| last5 = Holton \| first5 = J. \| last6 = Xiromerisiou \| first6 = G. \| last7 = Lees \| first7 = A. \| last8 = Houlden \| first8 = H. \| last9 = Revesz \| first9 = T. \| title = TDP-43 pathology in a patient carrying G2019S LRRK2 mutation and a novel p.Q124E MAPT. \| journal = Neurobiol Aging \| volume = 34 \| issue = 12 \| pages = 2889.e5-9 \| month = Dec \| year = 2013 \| doi = 10.1016/j.neurobiolaging.2013.04.011 \| PMID = 23664753 }}</ref>		*[[Lewy body disease]] (LBD).<ref>{{Cite journal \| last1 = Ling \| first1 = H. \| last2 = Kara \| first2 = E. \| last3 = Bandopadhyay \| first3 = R. \| last4 = Hardy \| first4 = J. \| last5 = Holton \| first5 = J. \| last6 = Xiromerisiou \| first6 = G. \| last7 = Lees \| first7 = A. \| last8 = Houlden \| first8 = H. \| last9 = Revesz \| first9 = T. \| title = TDP-43 pathology in a patient carrying G2019S LRRK2 mutation and a novel p.Q124E MAPT. \| journal = Neurobiol Aging \| volume = 34 \| issue = 12 \| pages = 2889.e5-9 \| month = Dec \| year = 2013 \| doi = 10.1016/j.neurobiolaging.2013.04.011 \| PMID = 23664753 }}</ref>
	*In 30% of non-demented individuals 65yrs and older.<ref>{{Cite journal \| last1 = Wilson \| first1 = AC. \| last2 = Dugger \| first2 = BN. \| last3 = Dickson \| first3 = DW. \| last4 = Wang \| first4 = DS. \| title = TDP-43 in aging and Alzheimer's disease - a review. \| journal = Int J Clin Exp Pathol \| volume = 4 \| issue = 2 \| pages = 147-55 \| month = Jan \| year = 2011 \| doi = \| PMID = 21326809 }}</ref>		*In 30% of non-demented individuals 65yrs and older.<ref>{{Cite journal \| last1 = Wilson \| first1 = AC. \| last2 = Dugger \| first2 = BN. \| last3 = Dickson \| first3 = DW. \| last4 = Wang \| first4 = DS. \| title = TDP-43 in aging and Alzheimer's disease - a review. \| journal = Int J Clin Exp Pathol \| volume = 4 \| issue = 2 \| pages = 147-55 \| month = Jan \| year = 2011 \| doi = \| PMID = 21326809 }}</ref>
			*[[Inclusion body myositis]] (IBM).<ref>{{Cite journal \| last1 = D'Agostino \| first1 = C. \| last2 = Nogalska \| first2 = A. \| last3 = Engel \| first3 = WK. \| last4 = Askanas \| first4 = V. \| title = In sporadic inclusion body myositis muscle fibres TDP-43-positive inclusions are less frequent and robust than p62 inclusions, and are not associated with paired helical filaments. \| journal = Neuropathol Appl Neurobiol \| volume = 37 \| issue = 3 \| pages = 315-20 \| month = Apr \| year = 2011 \| doi = 10.1111/j.1365-2990.2010.01108.x \| PMID = 20626631 }}</ref>


	===Images===		===Images===
	<gallery>		<gallery>
	FTLD TSP43 hippocampus.jpg \| Pan-TDP43 immunohistochemisty.		FTLD TSP43 hippocampus.jpg \| Pan-TDP43 immunohistochemisty. Pathological cytoplasmic inclusions.
	</gallery>		</gallery>

Jensflorian: + LBD

2018-07-05T11:58:45Z

+ LBD

← Older revision		Revision as of 11:58, 5 July 2018
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	==Inclusions found==		==Inclusions found==
	*[[FTLD TDP-43]]		*Frontotemporal dementias [[FTLD TDP-43]] <ref>{{Cite journal \| last1 = Neumann \| first1 = M. \| title = Molecular neuropathology of TDP-43 proteinopathies. \| journal = Int J Mol Sci \| volume = 10 \| issue = 1 \| pages = 232-46 \| month = Jan \| year = 2009 \| doi = 10.3390/ijms10010232 \| PMID = 19333444 }}</ref>
	* Alzheimer disease.<ref>{{Cite journal \| last1 = Wilson \| first1 = AC. \| last2 = Dugger \| first2 = BN. \| last3 = Dickson \| first3 = DW. \| last4 = Wang \| first4 = DS. \| title = TDP-43 in aging and Alzheimer's disease - a review. \| journal = Int J Clin Exp Pathol \| volume = 4 \| issue = 2 \| pages = 147-55 \| month = Jan \| year = 2011 \| doi = \| PMID = 21326809 }}</ref>		* [[Alzheimer disease]].<ref>{{Cite journal \| last1 = Wilson \| first1 = AC. \| last2 = Dugger \| first2 = BN. \| last3 = Dickson \| first3 = DW. \| last4 = Wang \| first4 = DS. \| title = TDP-43 in aging and Alzheimer's disease - a review. \| journal = Int J Clin Exp Pathol \| volume = 4 \| issue = 2 \| pages = 147-55 \| month = Jan \| year = 2011 \| doi = \| PMID = 21326809 }}</ref>
	*[[Chronic traumatic encephalopathy]] (CTE).<ref>{{Cite journal \| last1 = McKee \| first1 = AC. \| last2 = Cairns \| first2 = NJ. \| last3 = Dickson \| first3 = DW. \| last4 = Folkerth \| first4 = RD. \| last5 = Keene \| first5 = CD. \| last6 = Litvan \| first6 = I. \| last7 = Perl \| first7 = DP. \| last8 = Stein \| first8 = TD. \| last9 = Vonsattel \| first9 = JP. \| title = The first NINDS/NIBIB consensus meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy. \| journal = Acta Neuropathol \| volume = 131 \| issue = 1 \| pages = 75-86 \| month = Jan \| year = 2016 \| doi = 10.1007/s00401-015-1515-z \| PMID = 26667418 }}</ref>		*[[Chronic traumatic encephalopathy]] (CTE).<ref>{{Cite journal \| last1 = McKee \| first1 = AC. \| last2 = Cairns \| first2 = NJ. \| last3 = Dickson \| first3 = DW. \| last4 = Folkerth \| first4 = RD. \| last5 = Keene \| first5 = CD. \| last6 = Litvan \| first6 = I. \| last7 = Perl \| first7 = DP. \| last8 = Stein \| first8 = TD. \| last9 = Vonsattel \| first9 = JP. \| title = The first NINDS/NIBIB consensus meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy. \| journal = Acta Neuropathol \| volume = 131 \| issue = 1 \| pages = 75-86 \| month = Jan \| year = 2016 \| doi = 10.1007/s00401-015-1515-z \| PMID = 26667418 }}</ref>
			*[[Lewy body disease]].<ref>{{Cite journal \| last1 = Ling \| first1 = H. \| last2 = Kara \| first2 = E. \| last3 = Bandopadhyay \| first3 = R. \| last4 = Hardy \| first4 = J. \| last5 = Holton \| first5 = J. \| last6 = Xiromerisiou \| first6 = G. \| last7 = Lees \| first7 = A. \| last8 = Houlden \| first8 = H. \| last9 = Revesz \| first9 = T. \| title = TDP-43 pathology in a patient carrying G2019S LRRK2 mutation and a novel p.Q124E MAPT. \| journal = Neurobiol Aging \| volume = 34 \| issue = 12 \| pages = 2889.e5-9 \| month = Dec \| year = 2013 \| doi = 10.1016/j.neurobiolaging.2013.04.011 \| PMID = 23664753 }}</ref>
	*In 30% of non-demented individuals 65yrs and older.<ref>{{Cite journal \| last1 = Wilson \| first1 = AC. \| last2 = Dugger \| first2 = BN. \| last3 = Dickson \| first3 = DW. \| last4 = Wang \| first4 = DS. \| title = TDP-43 in aging and Alzheimer's disease - a review. \| journal = Int J Clin Exp Pathol \| volume = 4 \| issue = 2 \| pages = 147-55 \| month = Jan \| year = 2011 \| doi = \| PMID = 21326809 }}</ref>		*In 30% of non-demented individuals 65yrs and older.<ref>{{Cite journal \| last1 = Wilson \| first1 = AC. \| last2 = Dugger \| first2 = BN. \| last3 = Dickson \| first3 = DW. \| last4 = Wang \| first4 = DS. \| title = TDP-43 in aging and Alzheimer's disease - a review. \| journal = Int J Clin Exp Pathol \| volume = 4 \| issue = 2 \| pages = 147-55 \| month = Jan \| year = 2011 \| doi = \| PMID = 21326809 }}</ref>

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	===Images===		===Images===
	<gallery>		<gallery>
			FTLD TSP43 hippocampus.jpg \| Pan-TDP43 immunohistochemisty.
	</gallery>		</gallery>

Jensflorian: +cte

2018-07-05T11:54:37Z

+cte

← Older revision		Revision as of 11:54, 5 July 2018
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	*[[FTLD TDP-43]]		*[[FTLD TDP-43]]
	* Alzheimer disease.<ref>{{Cite journal \| last1 = Wilson \| first1 = AC. \| last2 = Dugger \| first2 = BN. \| last3 = Dickson \| first3 = DW. \| last4 = Wang \| first4 = DS. \| title = TDP-43 in aging and Alzheimer's disease - a review. \| journal = Int J Clin Exp Pathol \| volume = 4 \| issue = 2 \| pages = 147-55 \| month = Jan \| year = 2011 \| doi = \| PMID = 21326809 }}</ref>		* Alzheimer disease.<ref>{{Cite journal \| last1 = Wilson \| first1 = AC. \| last2 = Dugger \| first2 = BN. \| last3 = Dickson \| first3 = DW. \| last4 = Wang \| first4 = DS. \| title = TDP-43 in aging and Alzheimer's disease - a review. \| journal = Int J Clin Exp Pathol \| volume = 4 \| issue = 2 \| pages = 147-55 \| month = Jan \| year = 2011 \| doi = \| PMID = 21326809 }}</ref>
			*[[Chronic traumatic encephalopathy]] (CTE).<ref>{{Cite journal \| last1 = McKee \| first1 = AC. \| last2 = Cairns \| first2 = NJ. \| last3 = Dickson \| first3 = DW. \| last4 = Folkerth \| first4 = RD. \| last5 = Keene \| first5 = CD. \| last6 = Litvan \| first6 = I. \| last7 = Perl \| first7 = DP. \| last8 = Stein \| first8 = TD. \| last9 = Vonsattel \| first9 = JP. \| title = The first NINDS/NIBIB consensus meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy. \| journal = Acta Neuropathol \| volume = 131 \| issue = 1 \| pages = 75-86 \| month = Jan \| year = 2016 \| doi = 10.1007/s00401-015-1515-z \| PMID = 26667418 }}</ref>
			*In 30% of non-demented individuals 65yrs and older.<ref>{{Cite journal \| last1 = Wilson \| first1 = AC. \| last2 = Dugger \| first2 = BN. \| last3 = Dickson \| first3 = DW. \| last4 = Wang \| first4 = DS. \| title = TDP-43 in aging and Alzheimer's disease - a review. \| journal = Int J Clin Exp Pathol \| volume = 4 \| issue = 2 \| pages = 147-55 \| month = Jan \| year = 2011 \| doi = \| PMID = 21326809 }}</ref>

Jensflorian: +alzheimer

2018-07-05T11:52:00Z

+alzheimer

← Older revision		Revision as of 11:52, 5 July 2018
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	{{ Infobox immunostain		{{ Infobox immunostain
	\| Name = {{PAGENAME}}		\| Name = {{PAGENAME}}
	\| Image = ~~File:~~FTLD TSP43 hippocampus.jpg		\| Image = FTLD TSP43 hippocampus.jpg
	\| Width =		\| Width =
	\| Caption = TDP-43 staining in FTLD-TDP43. (WC)		\| Caption = TDP-43 staining in FTLD-TDP43. (WC)
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	*Nuclear staining.		*Nuclear staining.

	==~~Normal tissues~~==		==Inclusion morphology==
	*		*fine / coarse skeins.
			*dot-like.
			*dense-round inclusions.

			==Inclusions found==
			*[[FTLD TDP-43]]
			* Alzheimer disease.<ref>{{Cite journal \| last1 = Wilson \| first1 = AC. \| last2 = Dugger \| first2 = BN. \| last3 = Dickson \| first3 = DW. \| last4 = Wang \| first4 = DS. \| title = TDP-43 in aging and Alzheimer's disease - a review. \| journal = Int J Clin Exp Pathol \| volume = 4 \| issue = 2 \| pages = 147-55 \| month = Jan \| year = 2011 \| doi = \| PMID = 21326809 }}</ref>

Jensflorian: create

2018-07-05T11:48:40Z

create

New page

{{ Infobox immunostain
| Name = {{PAGENAME}}
| Image = File:FTLD TSP43 hippocampus.jpg
| Width =
| Caption = TDP-43 staining in FTLD-TDP43. (WC)
| Abbrev =
| Synonyms =
| Similar =
| Clones =
| Use =
| Subspecial =
| Pattern = nuclear staining (physiological)
| Positive = cytoplasmatic staining (pathological)
| Negative =
| Other =
}}
'''TAR-DNA-binding Protein 43''', abbreviated '''TDP-43''' is a neuropathology immunostain used in neurodegenerative diseases.
*Nuclear staining.

==Normal tissues==
*

===Images===
<gallery>

</gallery>

==See also==
*[[Immunohistochemistry]].

==References==
{{Reflist|1}}

[[Category:Immunohistochemistry]]
[[Category:Neuropathology]]

← Older revision		Revision as of 12:03, 5 July 2018
Line 27:		Line 27:
	* [[Alzheimer disease]].<ref>{{Cite journal \| last1 = Wilson \| first1 = AC. \| last2 = Dugger \| first2 = BN. \| last3 = Dickson \| first3 = DW. \| last4 = Wang \| first4 = DS. \| title = TDP-43 in aging and Alzheimer's disease - a review. \| journal = Int J Clin Exp Pathol \| volume = 4 \| issue = 2 \| pages = 147-55 \| month = Jan \| year = 2011 \| doi = \| PMID = 21326809 }}</ref>		* [[Alzheimer disease]].<ref>{{Cite journal \| last1 = Wilson \| first1 = AC. \| last2 = Dugger \| first2 = BN. \| last3 = Dickson \| first3 = DW. \| last4 = Wang \| first4 = DS. \| title = TDP-43 in aging and Alzheimer's disease - a review. \| journal = Int J Clin Exp Pathol \| volume = 4 \| issue = 2 \| pages = 147-55 \| month = Jan \| year = 2011 \| doi = \| PMID = 21326809 }}</ref>
	*[[Chronic traumatic encephalopathy]] (CTE).<ref>{{Cite journal \| last1 = McKee \| first1 = AC. \| last2 = Cairns \| first2 = NJ. \| last3 = Dickson \| first3 = DW. \| last4 = Folkerth \| first4 = RD. \| last5 = Keene \| first5 = CD. \| last6 = Litvan \| first6 = I. \| last7 = Perl \| first7 = DP. \| last8 = Stein \| first8 = TD. \| last9 = Vonsattel \| first9 = JP. \| title = The first NINDS/NIBIB consensus meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy. \| journal = Acta Neuropathol \| volume = 131 \| issue = 1 \| pages = 75-86 \| month = Jan \| year = 2016 \| doi = 10.1007/s00401-015-1515-z \| PMID = 26667418 }}</ref>		*[[Chronic traumatic encephalopathy]] (CTE).<ref>{{Cite journal \| last1 = McKee \| first1 = AC. \| last2 = Cairns \| first2 = NJ. \| last3 = Dickson \| first3 = DW. \| last4 = Folkerth \| first4 = RD. \| last5 = Keene \| first5 = CD. \| last6 = Litvan \| first6 = I. \| last7 = Perl \| first7 = DP. \| last8 = Stein \| first8 = TD. \| last9 = Vonsattel \| first9 = JP. \| title = The first NINDS/NIBIB consensus meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy. \| journal = Acta Neuropathol \| volume = 131 \| issue = 1 \| pages = 75-86 \| month = Jan \| year = 2016 \| doi = 10.1007/s00401-015-1515-z \| PMID = 26667418 }}</ref>
	*[[Lewy body disease]].<ref>{{Cite journal \| last1 = Ling \| first1 = H. \| last2 = Kara \| first2 = E. \| last3 = Bandopadhyay \| first3 = R. \| last4 = Hardy \| first4 = J. \| last5 = Holton \| first5 = J. \| last6 = Xiromerisiou \| first6 = G. \| last7 = Lees \| first7 = A. \| last8 = Houlden \| first8 = H. \| last9 = Revesz \| first9 = T. \| title = TDP-43 pathology in a patient carrying G2019S LRRK2 mutation and a novel p.Q124E MAPT. \| journal = Neurobiol Aging \| volume = 34 \| issue = 12 \| pages = 2889.e5-9 \| month = Dec \| year = 2013 \| doi = 10.1016/j.neurobiolaging.2013.04.011 \| PMID = 23664753 }}</ref>		*[[Lewy body disease]] (LBD).<ref>{{Cite journal \| last1 = Ling \| first1 = H. \| last2 = Kara \| first2 = E. \| last3 = Bandopadhyay \| first3 = R. \| last4 = Hardy \| first4 = J. \| last5 = Holton \| first5 = J. \| last6 = Xiromerisiou \| first6 = G. \| last7 = Lees \| first7 = A. \| last8 = Houlden \| first8 = H. \| last9 = Revesz \| first9 = T. \| title = TDP-43 pathology in a patient carrying G2019S LRRK2 mutation and a novel p.Q124E MAPT. \| journal = Neurobiol Aging \| volume = 34 \| issue = 12 \| pages = 2889.e5-9 \| month = Dec \| year = 2013 \| doi = 10.1016/j.neurobiolaging.2013.04.011 \| PMID = 23664753 }}</ref>
	*In 30% of non-demented individuals 65yrs and older.<ref>{{Cite journal \| last1 = Wilson \| first1 = AC. \| last2 = Dugger \| first2 = BN. \| last3 = Dickson \| first3 = DW. \| last4 = Wang \| first4 = DS. \| title = TDP-43 in aging and Alzheimer's disease - a review. \| journal = Int J Clin Exp Pathol \| volume = 4 \| issue = 2 \| pages = 147-55 \| month = Jan \| year = 2011 \| doi = \| PMID = 21326809 }}</ref>		*In 30% of non-demented individuals 65yrs and older.<ref>{{Cite journal \| last1 = Wilson \| first1 = AC. \| last2 = Dugger \| first2 = BN. \| last3 = Dickson \| first3 = DW. \| last4 = Wang \| first4 = DS. \| title = TDP-43 in aging and Alzheimer's disease - a review. \| journal = Int J Clin Exp Pathol \| volume = 4 \| issue = 2 \| pages = 147-55 \| month = Jan \| year = 2011 \| doi = \| PMID = 21326809 }}</ref>
			*[[Inclusion body myositis]] (IBM).<ref>{{Cite journal \| last1 = D'Agostino \| first1 = C. \| last2 = Nogalska \| first2 = A. \| last3 = Engel \| first3 = WK. \| last4 = Askanas \| first4 = V. \| title = In sporadic inclusion body myositis muscle fibres TDP-43-positive inclusions are less frequent and robust than p62 inclusions, and are not associated with paired helical filaments. \| journal = Neuropathol Appl Neurobiol \| volume = 37 \| issue = 3 \| pages = 315-20 \| month = Apr \| year = 2011 \| doi = 10.1111/j.1365-2990.2010.01108.x \| PMID = 20626631 }}</ref>


	===Images===		===Images===
	<gallery>		<gallery>
	FTLD TSP43 hippocampus.jpg \| Pan-TDP43 immunohistochemisty.		FTLD TSP43 hippocampus.jpg \| Pan-TDP43 immunohistochemisty. Pathological cytoplasmic inclusions.
	</gallery>		</gallery>