Wilms tumour - Revision history

Abraham: /* General */

2018-10-14T05:48:12Z

General

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	*Common abdominal [[pediatric pathology\|pediatric]] tumour.		*Common abdominal [[pediatric pathology\|pediatric]] tumour.
	**Affects approximately 1 in 8000 children.		**Affects approximately 1 in 8000 children.
	**There is no sex predilection and the mean patient age ~~pf presentation~~ ranges among 37 to 43 months.		**There is no sex predilection and the mean patient age at diagnosis ranges among 37 to 43 months.
	*May be associated with a syndrome:<ref>URL: [http://emedicine.medscape.com/article/989398-overview http://emedicine.medscape.com/article/989398-overview]. Accessed on: 9 March 2011.</ref>		*May be associated with a syndrome:<ref>URL: [http://emedicine.medscape.com/article/989398-overview http://emedicine.medscape.com/article/989398-overview]. Accessed on: 9 March 2011.</ref>
	**WAGR syndrome (Wilms tumour, Aniridia (absence of iris), GU abnormalities, Retardation).<ref>{{OMIM\|194072}}</ref>		**WAGR syndrome (Wilms tumour, Aniridia (absence of iris), GU abnormalities, Retardation).<ref>{{OMIM\|194072}}</ref>

Abraham: /* General */

2018-10-14T05:47:35Z

General

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	==General==		==General==
	*Common abdominal [[pediatric pathology\|pediatric]] tumour.		*Common abdominal [[pediatric pathology\|pediatric]] tumour.
			**Affects approximately 1 in 8000 children.
			**There is no sex predilection and the mean patient age pf presentation ranges among 37 to 43 months.
	*May be associated with a syndrome:<ref>URL: [http://emedicine.medscape.com/article/989398-overview http://emedicine.medscape.com/article/989398-overview]. Accessed on: 9 March 2011.</ref>		*May be associated with a syndrome:<ref>URL: [http://emedicine.medscape.com/article/989398-overview http://emedicine.medscape.com/article/989398-overview]. Accessed on: 9 March 2011.</ref>
	**WAGR syndrome (Wilms tumour, Aniridia (absence of iris), GU abnormalities, Retardation).<ref>{{OMIM\|194072}}</ref>		**WAGR syndrome (Wilms tumour, Aniridia (absence of iris), GU abnormalities, Retardation).<ref>{{OMIM\|194072}}</ref>

Abraham: /* Gross */

2018-10-14T05:43:29Z

Gross

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	==Gross==		==Gross==
	Features <ref name="pmid10193955">{{~~Cita publicación~~ \| ~~apellido~~ = Coppes \| ~~nombre~~ = MJ. \| ~~coautores~~ = M. ~~Arnold,~~ JB. ~~Beckwith,~~ ML. ~~Ritchey, GJ.~~ D'Angio, DM. ~~Green,~~ NE. ~~Breslow~~ \| ~~título~~ = Factors affecting the risk of contralateral Wilms tumor development: a report from the National Wilms Tumor Study Group. \| ~~publicación~~ = Cancer \| volume = 85 \| ~~número~~ = 7 \| ~~páginas~~ = 1616-25 \| ~~mes~~ = Apr \| ~~año~~ = 1999 \| doi = \| ~~pmid~~ = 10193955 }}</ref>		Features <ref name="pmid10193955">{{Cite journal \| last1 = Coppes \| first1 = MJ. \| last2 = Arnold \| first2 = M. \| last3 = Beckwith \| first3 = JB. \| last4 = Ritchey \| first4 = ML. \| last5 = D'Angio \| first5 = GJ. \| last6 = Green \| first6 = DM. \| last7 = Breslow \| first7 = NE. \| title = Factors affecting the risk of contralateral Wilms tumor development: a report from the National Wilms Tumor Study Group. \| journal = Cancer \| volume = 85 \| issue = 7 \| pages = 1616-25 \| month = Apr \| year = 1999 \| doi = \| PMID = 10193955 }}</ref>
	*Most nephroblastomas are unifocal.		*Most nephroblastomas are unifocal.
	**Usually solitary, rounded, multilobular masses sharply demarcated from adjacent parenchyma.		**Usually solitary, rounded, multilobular masses sharply demarcated from adjacent parenchyma.

Abraham: /* Gross */

2018-10-14T05:40:58Z

Gross

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	==Gross==		==Gross==
			Features <ref name="pmid10193955">{{Cita publicación \| apellido = Coppes \| nombre = MJ. \| coautores = M. Arnold, JB. Beckwith, ML. Ritchey, GJ. D'Angio, DM. Green, NE. Breslow \| título = Factors affecting the risk of contralateral Wilms tumor development: a report from the National Wilms Tumor Study Group. \| publicación = Cancer \| volume = 85 \| número = 7 \| páginas = 1616-25 \| mes = Apr \| año = 1999 \| doi = \| pmid = 10193955 }}</ref>
	*Most nephroblastomas are unifocal.		*Most nephroblastomas are unifocal.
	**Usually solitary, rounded, multilobular masses sharply demarcated from adjacent parenchyma.		**Usually solitary, rounded, multilobular masses sharply demarcated from adjacent parenchyma.

Abraham: /* Gross */

2018-10-14T05:36:52Z

Gross

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	==Gross==		==Gross==
	*~~Lobulated~~ tan ~~mass~~.		*Most nephroblastomas are unifocal.
			**Usually solitary, rounded, multilobular masses sharply demarcated from adjacent parenchyma.
			**The cut surface is most commonly pale grey or tan.
			**Cyst most be prominent in some cases.
			*Multifocal masses in a single kidney and bilateral primary lesions are less frequent.

	===Images===		===Images===

Abraham: /* Microscopic */

2017-08-24T02:16:27Z

Microscopic

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	Features - classically three components (blastema, immature stroma, tubules):<ref name=Ref_PCPBoD8_254-5>{{Ref PCPBoD8\|254-5}}</ref>		Features - classically three components (blastema, immature stroma, tubules):<ref name=Ref_PCPBoD8_254-5>{{Ref PCPBoD8\|254-5}}</ref>
	#Malignant [[Small round blue cell tumours\|small round blue cells]] ("blastema"):		#Malignant [[Small round blue cell tumours\|small round blue cells]] ("blastema"):
			#*The blastemal component is the least differentiated cellular element.
	#*Size = ~ 2x RBC diameter.		#*Size = ~ 2x RBC diameter.
	#*Nuclear pleomorphism (variation of size, shape and staining).		#*Nuclear pleomorphism (variation of size, shape and staining).

Abraham: /* Microscopic */

2017-08-22T15:39:13Z

Microscopic

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	#**Elliptical nuclear membrane.		#**Elliptical nuclear membrane.
	#**Abundant loose cytoplasm.		#**Abundant loose cytoplasm.
	#~~Tubular structures~~ ("tubules"):		#Epithelial components ("tubules"):
	#*~~Usually clustered~~.		#*Primitive rossete-like tubules, well-formed maturing and mature tubules, glomerular structures and variably papillary architecture.
	#*~~Vaguely resemble a glomerulus~~.		#**Usually clustered.
	#*Usu. have a central (clear/white) space surrounded by a rim of intensely eosinophilic cytoplasm.		#**Usu. have a central (clear/white) space surrounded by a rim of intensely eosinophilic cytoplasm.
	#*Nuclei of tubular structures often elongated and palisaded.		#**Nuclei of tubular structures often elongated and palisaded.

	Other findings:		Other findings:

Abraham at 18:53, 20 August 2017

2017-08-20T18:53:26Z

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	*CD56 +ve.<ref name=pmid11688464>{{Cite journal \| last1 = Muir \| first1 = TE. \| last2 = Cheville \| first2 = JC. \| last3 = Lager \| first3 = DJ. \| title = Metanephric adenoma, nephrogenic rests, and Wilms' tumor: a histologic and immunophenotypic comparison. \| journal = Am J Surg Pathol \| volume = 25 \| issue = 10 \| pages = 1290-6 \| month = Oct \| year = 2001 \| doi = \| PMID = 11688464 }}</ref>		*CD56 +ve.<ref name=pmid11688464>{{Cite journal \| last1 = Muir \| first1 = TE. \| last2 = Cheville \| first2 = JC. \| last3 = Lager \| first3 = DJ. \| title = Metanephric adenoma, nephrogenic rests, and Wilms' tumor: a histologic and immunophenotypic comparison. \| journal = Am J Surg Pathol \| volume = 25 \| issue = 10 \| pages = 1290-6 \| month = Oct \| year = 2001 \| doi = \| PMID = 11688464 }}</ref>
	**-ve in [[metanephric adenoma]].		**-ve in [[metanephric adenoma]].

			==Molecular==
			*Cytogenetics<ref>{{Cite journal \| last1 = Md Zin \| first1 = R. \| last2 = Murch \| first2 = A. \| last3 = Charles \| first3 = A. \| title = Pathology, genetics and cytogenetics of Wilms' tumour. \| journal = Pathology \| volume = 43 \| issue = 4 \| pages = 302-12 \| month = Jun \| year = 2011 \| doi = 10.1097/PAT.0b013e3283463575 \| PMID = 21516053 }}</ref>
			**Partial gains of 1q.
			**Partial losses of 1p, 1q, 4q, 11q, 16q, 22q.
			**Complete loss of chromosome 16, 11, 12, 22.
			**Trisomy of chromosome 8, 12, 13, 18.

	==See also==		==See also==

Abraham: /* Gross */

2017-08-20T03:09:04Z

Gross

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	www:		www:
	*[http://library.med.utah.edu/WebPath/EXAM/IMGQUIZ/rnfrm.html Wilms tumour (med.utah.edu)].		*[http://library.med.utah.edu/WebPath/EXAM/IMGQUIZ/rnfrm.html Wilms tumour (med.utah.edu)].
	*[http://www.webpathology.com/image.asp?case=73&n=1 (WebPathology)].		*[http://www.webpathology.com/image.asp?case=73&n=1 Wilms tumour (WebPathology)].

	==Microscopic==		==Microscopic==

Abraham: /* Microscopic */

2017-08-20T03:00:19Z

Microscopic

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	*Other [[small round cell tumours]].		*Other [[small round cell tumours]].
	*[[Synovial sarcoma]], biphasic - especially in adults.		*[[Synovial sarcoma]], biphasic - especially in adults.
			*Immature teratoma.

	Notes:		Notes: