Difference between revisions of "Progressive transformation of germinal centers"
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Progressive_transformation_of_germinal_centres_-1-_very_low_mag.jpg | |||
| Width = | |||
| Caption = PTGC. [[H&E stain]]. | |||
| Micro = follicular hyperplasia with focally large germinal centers with a poorly demarcated germinal center (GC)/mantle zone interfaces (as GCs infiltrated by mantle zone lymphocytes), expanded mantle zone | |||
| Subtypes = | |||
| LMDDx = [[nodular lymphocyte predominant Hodgkin lymphoma]], other lymphomas | |||
| Stains = | |||
| IHC = | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[lymph node]] | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = lymphadenopathy | |||
| Symptoms = asymptomatic | |||
| Prevalence = very rare | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = | |||
| Other = | |||
| ClinDDx = [[lymph node metastasis]], [[lymphoma]] | |||
}} | |||
'''Progressive transformation of germinal centers''', abbreviated '''PTGC''', is a rare [[lymph node pathology]]. | '''Progressive transformation of germinal centers''', abbreviated '''PTGC''', is a rare [[lymph node pathology]]. | ||
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*Benign. | *Benign. | ||
*Classically in younger patients. | *Classically in younger patients. | ||
*Associated with nodular lymphocyte predominant | *Associated with [[nodular lymphocyte predominant Hodgkin lymphoma]] (NLPHL); NLPHL found in up to 5% in a 7 year follow-up.<ref name=pmid12145465>{{cite journal |author=Verma A, Stock W, Norohna S, Shah R, Bradlow B, Platanias LC |title=Progressive transformation of germinal centers. Report of 2 cases and review of the literature |journal=Acta Haematol. |volume=108 |issue=1 |pages=33–8 |year=2002 |pmid=12145465 |doi= |url=}}</ref> | ||
Clinical: | Clinical: | ||
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**Expanded mantle zone. | **Expanded mantle zone. | ||
Images: | ===Images=== | ||
<gallery> | |||
Image:Progressive transformation of germinal centres -1- low mag.jpg| PTGCs - low mag. (WC) | |||
Image:Progressive transformation of germinal centres -1- intermed mag.jpg| PTGCs - intermed. mag. (WC) | |||
</gallery> | |||
<gallery> | |||
Image:Progressive transformation of germinal centers -2- very low mag.jpg| PTGCs - very low mag. (WC) | |||
Image:Progressive transformation of germinal centers -2- low mag.jpg| PTGCs - low mag. (WC) | |||
Image:Progressive transformation of germinal centers -2- intermed mag.jpg| PTGCs - intermed. mag. (WC) | |||
</gallery> | |||
==See also== | ==See also== | ||
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[[Category:Lymph node pathology]] | [[Category:Lymph node pathology]] | ||
[[Category:Diagnosis]] |
Latest revision as of 04:22, 5 September 2013
Progressive transformation of germinal centers | |
---|---|
Diagnosis in short | |
PTGC. H&E stain. | |
| |
LM | follicular hyperplasia with focally large germinal centers with a poorly demarcated germinal center (GC)/mantle zone interfaces (as GCs infiltrated by mantle zone lymphocytes), expanded mantle zone |
LM DDx | nodular lymphocyte predominant Hodgkin lymphoma, other lymphomas |
Site | lymph node |
| |
Signs | lymphadenopathy |
Symptoms | asymptomatic |
Prevalence | very rare |
Clin. DDx | lymph node metastasis, lymphoma |
Progressive transformation of germinal centers, abbreviated PTGC, is a rare lymph node pathology.
General
- Benign.
- Classically in younger patients.
- Associated with nodular lymphocyte predominant Hodgkin lymphoma (NLPHL); NLPHL found in up to 5% in a 7 year follow-up.[1]
Clinical:
- Asymptomatic lymphadenopathy.
Microscopic
Features:
- Follicular hyperplasia (many follicles).
- Focally large germinal centers with:
- Poorly demarcated germinal center (GC)/mantle zone interfaces (as GCs infiltrated by mantle zone lymphocytes) -- key feature.[1]
- Expanded mantle zone.
Images
See also
References
Additional reading
- Hansmann ML, Fellbaum C, Hui PK, Moubayed P (February 1990). "Progressive transformation of germinal centers with and without association to Hodgkin's disease". Am. J. Clin. Pathol. 93 (2): 219–26. PMID 2405631.
- Kojima M, Nakamura S, Motoori T, et al. (April 2003). "Progressive transformation of germinal centers: a clinicopathological study of 42 Japanese patients". Int. J. Surg. Pathol. 11 (2): 101–7. PMID 12754626.