Difference between revisions of "Squamous cell carcinoma of the lung"

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| Other      =
| Other      =
| ClinDDx    = other [[lung tumours]] - esp. [[small cell carcinoma of the lung]]
| ClinDDx    = other [[lung tumours]] - esp. [[small cell carcinoma of the lung]]
| Tx        =
| Tx        = surgical if possible resection
}}
}}
'''Squamous cell carcinoma of the lung''', also '''lung squamous cell carcinoma''', is a common [[cancer|malignant]] [[lung tumour]] that is associated with [[smoking]].
'''Squamous cell carcinoma of the lung''', also '''lung squamous cell carcinoma''', is a common [[cancer|malignant]] [[lung tumour]] that is associated with [[smoking]].


Revision as of 03:45, 12 January 2014

Squamous cell carcinoma of the lung
Diagnosis in short

Squamous cell carcinoma of the lung. Pap stain.
Synonyms squamous carcinoma of the lung
LM DDx lung adenocarcinoma, non-small cell lung carcinoma, metastatic squamous cell carcinoma, others
IHC p40 +ve, p63 +ve, TTF-1 -ve, CK7 -ve
Site lung - see lung tumours
Clinical history smoking
Symptoms +/-hemoptysis
Prevalence common
Blood work serum calcium elevated
Radiology typically a large airway mass, +/-spiculated, +/-cavitation
Prognosis usually poor
Clin. DDx other lung tumours - esp. small cell carcinoma of the lung
Treatment surgical if possible resection

Squamous cell carcinoma of the lung, also lung squamous cell carcinoma, is a common malignant lung tumour that is associated with smoking.

General

  • Strong association with smoking.
  • May be treated with surgery.

Clinical:

  • May be associated with elevated serum calcium.[1]
  • +/-Hemoptysis.

Gross

  • Usually centrally located, i.e. large airways.

Image

  • Squamous carcinoma of the lung. (WC)

Microscopic

Features:

  • Central nucleus.
  • Dense appearing cytoplasm, usu. eosinophilic.
  • +/-Small nucleolus.

DDx:

IHC

  • p40 +ve.[2]
    • p63 +ve -- less specific.
  • TTF-1 -ve.
    • Positive in adenocarcinoma.
  • Calponin -ve.
  • CK5/6 +ve.

See also

References

  1. ↑ Campbell, JH.; Ralston, S.; Boyle, IT.; Banham, SW. (May 1991). "Symptomatic hypercalcaemia in lung cancer.". Respir Med 85 (3): 223-7. PMID 1831917.
  2. ↑ Bishop, JA.; Teruya-Feldstein, J.; Westra, WH.; Pelosi, G.; Travis, WD.; Rekhtman, N. (Mar 2012). "p40 (ΔNp63) is superior to p63 for the diagnosis of pulmonary squamous cell carcinoma.". Mod Pathol 25 (3): 405-15. doi:10.1038/modpathol.2011.173. PMID 22056955.
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