Difference between revisions of "Enteropathy-associated T-cell lymphoma"
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==IHC== | ==IHC== | ||
Features - type 1:<ref name=pmid21323966/> | Features - type 1:<ref name=pmid21323966/> | ||
*CD56 +ve. | *[[CD56]] +ve. | ||
Features - type 2:<ref name=pmid21323966/><ref name=pmid21921780>{{Cite journal | last1 = Chan | first1 = JK. | last2 = Chan | first2 = AC. | last3 = Cheuk | first3 = W. | last4 = Wan | first4 = SK. | last5 = Lee | first5 = WK. | last6 = Lui | first6 = YH. | last7 = Chan | first7 = WK. | title = Type II enteropathy-associated T-cell lymphoma: a distinct aggressive lymphoma with frequent γδ T-cell receptor expression. | journal = Am J Surg Pathol | volume = 35 | issue = 10 | pages = 1557-69 | month = Oct | year = 2011 | doi = 10.1097/PAS.0b013e318222dfcd | PMID = 21921780 }}</ref> | Features - type 2:<ref name=pmid21323966/><ref name=pmid21921780>{{Cite journal | last1 = Chan | first1 = JK. | last2 = Chan | first2 = AC. | last3 = Cheuk | first3 = W. | last4 = Wan | first4 = SK. | last5 = Lee | first5 = WK. | last6 = Lui | first6 = YH. | last7 = Chan | first7 = WK. | title = Type II enteropathy-associated T-cell lymphoma: a distinct aggressive lymphoma with frequent γδ T-cell receptor expression. | journal = Am J Surg Pathol | volume = 35 | issue = 10 | pages = 1557-69 | month = Oct | year = 2011 | doi = 10.1097/PAS.0b013e318222dfcd | PMID = 21921780 }}</ref> |
Revision as of 08:03, 13 September 2014
Enteropathy-associated T-cell lymphoma, abbreviated EATL, is an uncommon type of lymphoma associated with celiac disease.
It is also known as enteropathy-type T-cell lymphoma, abbreviated ETTL.
General
- T cell lymphoma due to celiac sprue.
- Subdivided into type I and type II.[1]
Microscopic
Features:[2]
- Large or medium-sized lymphoid cells in the mucosa and submucosa.
- Large-sized cells ~ 2x RBC diameter = type 1.
- Medium sized cells ~ 1.5x RBC diameter = type 2.
- Intestinal epithelium usually preserved.
Image
IHC
Features - type 1:[2]
- CD56 +ve.
- CD3 +ve.
- CD5 -ve.
- CD8 -ve/+ve.
- CD56 -ve/+ve.
- CD30 +ve.
See also
References
- ↑ Delabie J, et al (July 2011). "Enteropathy-associated T-cell lymphoma: clinical and histological findings from the International Peripheral T-Cell Lymphoma Project". Blood 118 (148): 148.
- ↑ 2.0 2.1 2.2 Takeshita, M.; Nakamura, S.; Kikuma, K.; Nakayama, Y.; Nimura, S.; Yao, T.; Urabe, S.; Ogawara, S. et al. (Feb 2011). "Pathological and immunohistological findings and genetic aberrations of intestinal enteropathy-associated T cell lymphoma in Japan.". Histopathology 58 (3): 395-407. doi:10.1111/j.1365-2559.2011.03768.x. PMID 21323966.
- ↑ Chan, JK.; Chan, AC.; Cheuk, W.; Wan, SK.; Lee, WK.; Lui, YH.; Chan, WK. (Oct 2011). "Type II enteropathy-associated T-cell lymphoma: a distinct aggressive lymphoma with frequent γδ T-cell receptor expression.". Am J Surg Pathol 35 (10): 1557-69. doi:10.1097/PAS.0b013e318222dfcd. PMID 21921780.