Difference between revisions of "ABCC2"
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==Papillary renal cell carcinoma== | ==Papillary renal cell carcinoma== | ||
ABCC2 staining is predictive of outcome in [[papillary renal cell carcinoma]] | ABCC2 staining is predictive of outcome in [[papillary renal cell carcinoma]]: | ||
*Brush border staining is associated with a worse survival.<ref name=pmid37680023>{{cite journal |authors=Castillo VF, Masoomian M, Trpkov K, Downes M, Brimo F, van der Kwast T, Yousef GM, Zakhary A, Rotondo F, Saad G, Nguyen VN, Kidanewold W, Streutker C, Rowsell C, Hamdani M, Saleeb RM |title=ABCC2 brush-border expression predicts outcome in papillary renal cell carcinoma: a multi-institutional study of 254 cases |journal=Histopathology |volume=83 |issue=6 |pages=949–958 |date=December 2023 |pmid=37680023 |doi=10.1111/his.15042 |url=}}</ref> | |||
*Brush border staining suggests response to immunotherapy.<ref>{{cite journal |authors=Castillo VF, Zakhary A, Rotondo F, Di Ciano-Oliveira C, Hamdani M, Adona E, van der Kwast T, Trpkov K, Saleeb R |title=Papillary renal cell carcinoma with high-ABCC2 shows an immune-evasive profile associated with favorable response to immunotherapy |journal=J Pathol |volume=268 |issue=2 |pages=188–199 |date=February 2026 |pmid=41259021 |doi=10.1002/path.70001 |url=}}</ref> | |||
Latest revision as of 22:59, 18 May 2026
ABCC2 is an immunostain.
Papillary renal cell carcinoma
ABCC2 staining is predictive of outcome in papillary renal cell carcinoma:
- Brush border staining is associated with a worse survival.[1]
- Brush border staining suggests response to immunotherapy.[2]
References
- ↑ Castillo VF, Masoomian M, Trpkov K, Downes M, Brimo F, van der Kwast T, Yousef GM, Zakhary A, Rotondo F, Saad G, Nguyen VN, Kidanewold W, Streutker C, Rowsell C, Hamdani M, Saleeb RM (December 2023). "ABCC2 brush-border expression predicts outcome in papillary renal cell carcinoma: a multi-institutional study of 254 cases". Histopathology 83 (6): 949–958. doi:10.1111/his.15042. PMID 37680023.
- ↑ Castillo VF, Zakhary A, Rotondo F, Di Ciano-Oliveira C, Hamdani M, Adona E, van der Kwast T, Trpkov K, Saleeb R (February 2026). "Papillary renal cell carcinoma with high-ABCC2 shows an immune-evasive profile associated with favorable response to immunotherapy". J Pathol 268 (2): 188–199. doi:10.1002/path.70001. PMID 41259021.