UTERINE CERVIX, BIOPSY:
- SQUAMOUS INTRAEPITHELIAL LESION, FAVOUR HIGH-GRADE -- SMALL FOCUS, SEE COMMENT.
- BENIGN ENDOCERVICAL EPITHELIUM PRESENT.
COMMENT:
The cytology has intermediate features.
A p16 immunostain strongly marks the full thickness of the thin (abnormal) squamous
epithelium seen in the plane of section, and a Ki-67 focally shows positive superficial cells. These findings favour the presence of a high-grade squamous intraepithelial lesion (HSIL).
A re-biopsy with close follow-up could be considered.
Idea
UTERINE CERVIX, 12 O'CLOCK, BIOPSY:
- HIGH-GRADE SQUAMOUS INTRAEPITHELIAL LESION (HSIL).
- VERY SCANT STRIPPED ENDOCERVICAL EPITHELIUM.
- ACUTE AND CHRONIC INFLAMMATION.
COMMENT:
A p16 immunostain marks the full thickness of the squamous epithelium and is
strong. A Ki-67 immunostain marks a mildly increased number of superficial
epithelial cells. A immunostain shows basal staining and superficial
non-staining in the region of HSIL.