B cell small lymphocytic lymphoma/chronic lymphocytic leukemia
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B cell small lymphocytic lymphoma/chronic lymphocytic leukemia, often referred to as chronic lymphocytic leukemia (abbreviated CLL) or small lymphocytic lymphoma (abbreviated SLL), is a common low-grade hematologic malignancy. That typically afflicts older individuals.
General
- Very common.
- Good prognosis.
Richter's transformation
- CLL/SLL may under go a Richter's transformation into a high-grade non-Hodgkin's lymphoma (NHL), e.g. DLBCL:[1]
- Incidence of transformation <5%.
- Prognosis < 1 year.
Microscopic
Features in a lymph node:[2]
- Mixed population of lymphoid cells with "proliferation centers" - key feature:
- Larger cells (~ 1.5x the size of resting lymphocyte ~ 12-15 micrometers):
- Nucleoli.
- Form (nodular) collections.
- Small dark cells (~ size of resting lymphocyte ~ 8-10 micrometers):
- Predominant population.
- Lack nucleolus.
- Larger cells (~ 1.5x the size of resting lymphocyte ~ 12-15 micrometers):
Images
www:
- CLL in the liver (pathologyatlas.ro).
- SLL in the parotid - several images (upmc.edu).
- CLL with Richter transformation - several images (upmc.edu).
IHC
Others:
- Cyclin D1 -ve.
Molecular
- Lacks t(11;14) seen in mantle cell lymphoma.
See also
References
- ↑ Tsimberidou AM, Keating MJ (April 2006). "Richter's transformation in chronic lymphocytic leukemia". Semin. Oncol. 33 (2): 250–6. doi:10.1053/j.seminoncol.2006.01.016. PMID 16616072.
- ↑ DG. 17 August 2010.
- ↑ URL: http://path.upmc.edu/cases/case296/dx.html. Accessed on: 14 January 2012.