MAP2
MICROTUBULE-ASSOCIATED PROTEIN 2, abbreviated MAP2,[1] is a common immunostain used in neuropathology and pulomary pathology. It's expression is associated with neuronal, glial or neuroendocrine differentiation
Positive
- CNS cortex, esp. neurons. [2]
- Oligodendroglioma, predominantly perinuclear [3]
- Ganglioglioma [4]
- Astrocytoma / Glioblastoma [5]
- Neurocytoma / Medulloblastoma [6]
- Dysembryoplastic neuroepithelial tumour [7]
- Small cell lung carcinoma [8]
- Carcinoid tumour [9]
- Merkel cell carcinoma [10]
Images
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Perinuclear MAP2 in Oligodendroglioma -
MAP2 in Medulloblastoma -
MAP2 in floating neurons of DNT -
MAP2 in astrocytoma
See also
References
- ↑ Online 'Mendelian Inheritance in Man' (OMIM) 157130
- ↑ Kalcheva, N.; Albala, J.; O'Guin, K.; Rubino, H.; Garner, C.; Shafit-Zagardo, B. (Nov 1995). "Genomic structure of human microtubule-associated protein 2 (MAP-2) and characterization of additional MAP-2 isoforms.". Proc Natl Acad Sci U S A 92 (24): 10894-8. PMID 7479905.
- ↑ Blümcke, I.; Becker, AJ.; Normann, S.; Hans, V.; Riederer, BM.; Krajewski, S.; Wiestler, OD.; Reifenberger, G. (Oct 2001). "Distinct expression pattern of microtubule-associated protein-2 in human oligodendrogliomas and glial precursor cells.". J Neuropathol Exp Neurol 60 (10): 984-93. PMID 11589429.
- ↑ Duggal, N.; Hammond, RR. (Mar 2002). "Nestin expression in ganglioglioma.". Exp Neurol 174 (1): 89-95. doi:10.1006/exnr.2001.7838. PMID 11869037.
- ↑ Wharton, SB.; Chan, KK.; Whittle, IR. (Mar 2002). "Microtubule-associated protein 2 (MAP-2) is expressed in low and high grade diffuse astrocytomas.". J Clin Neurosci 9 (2): 165-9. doi:10.1054/jocn.2001.1055. PMID 11922706.
- ↑ Liu, Y.; Saad, RS.; Shen, SS.; Silverman, JF. (Mar 2003). "Diagnostic value of microtubule-associated protein-2 (MAP-2) for neuroendocrine neoplasms.". Adv Anat Pathol 10 (2): 101-6. PMID 12605092.
- ↑ Duggal, N.; Iskander, S.; Hammond, RR.. "MAP2 and nestin co-expression in dysembryoplastic neuroepithelial tumors.". Clin Neuropathol 22 (2): 57-65. PMID 12670051.
- ↑ Zhou, DM.; Sun, Y.; Li, XH. (May 2013). "[Diagnostic value of microtubule-associated protein-2 in small cell lung carcinoma: an analysis of 240 biopsy cases].". Zhonghua Bing Li Xue Za Zhi 42 (5): 321-4. PMID 24004589.
- ↑ Liu, Y.; Sturgis, CD.; Grzybicki, DM.; Jasnosz, KM.; Olson, PR.; Tong, M.; Dabbs, DD.; Raab, SS. et al. (Sep 2001). "Microtubule-associated protein-2: a new sensitive and specific marker for pulmonary carcinoid tumor and small cell carcinoma.". Mod Pathol 14 (9): 880-5. doi:10.1038/modpathol.3880406. PMID 11557784.
- ↑ Liu, Y.; Mangini, J.; Saad, R.; Silverman, AR.; Abell, E.; Tung, MY.; Graner, SR.; Silverman, JF. (Dec 2003). "Diagnostic value of microtubule-associated protein-2 in Merkel cell carcinoma.". Appl Immunohistochem Mol Morphol 11 (4): 326-9. PMID 14663358.