Signet ring cell-like adenocarcinoma of the prostate
Signet ring cell carcinoma of the prostate, also prostatic signet ring cell carcinoma, is a rare aggressive form of prostate cancer.
General
- Very rare - 9 cases in a series of 29,783 prostate cancer cases.[1]
- Criteria vary - percentage of SRCs required for Dx varies from 20% to 50%.[1]
Microscopic
Features:
- Signet ring cells - see basics article.
- +/-Conventional prostatic carcinoma.
DDx:
- Acinar adenocarcinoma - Gleason pattern 4 with very small glands.
- Metastatic signet ring cell carcinoma.
Images
- Prostatic SRCC (nih.gov).
- Prostatic SRCC (nature.com).
- Prostatic SRCC (nature.com).
- Prostatic SRCC (webpathology.com) - looks like acinar adenocarcinoma.
Stains
- Alcian blue-PAS stain +ve.
- PAS -- 50% of cases +ve.[1]
- Alcian blue -- 44% of cases +ve.[1]
Note:
- May be mucin stain -ve.
IHC
- PSAP +ve.[1]
- PSA +ve.
- CEA -ve.
Note:
- If prostate stains (PSAP, PSA, NKX3.1) are negative, a GI primary should be excluded. Clinical correlation may be required.