Difference between revisions of "CD56"

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'''CD56''' is a commonly available [[immunostain]] that is seen in a number of tumours. It is a sensitive marker of neuroendocrine differentiation.
'''CD56''' is a commonly available [[immunostain]] that is seen in a number of tumours. It is a sensitive [[neuroendocrine marker|marker of neuroendocrine differentiation]].


==Positive==
==Positive==
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*[[Merkel cell carcinoma]].<ref name=pmid12727026>{{Cite journal  | last1 = Kurokawa | first1 = M. | last2 = Nabeshima | first2 = K. | last3 = Akiyama | first3 = Y. | last4 = Maeda | first4 = S. | last5 = Nishida | first5 = T. | last6 = Nakayama | first6 = F. | last7 = Amano | first7 = M. | last8 = Ogata | first8 = K. | last9 = Setoyama | first9 = M. | title = CD56: a useful marker for diagnosing Merkel cell carcinoma. | journal = J Dermatol Sci | volume = 31 | issue = 3 | pages = 219-24 | month = May | year = 2003 | doi =  | PMID = 12727026 }}</ref>
*[[Merkel cell carcinoma]].<ref name=pmid12727026>{{Cite journal  | last1 = Kurokawa | first1 = M. | last2 = Nabeshima | first2 = K. | last3 = Akiyama | first3 = Y. | last4 = Maeda | first4 = S. | last5 = Nishida | first5 = T. | last6 = Nakayama | first6 = F. | last7 = Amano | first7 = M. | last8 = Ogata | first8 = K. | last9 = Setoyama | first9 = M. | title = CD56: a useful marker for diagnosing Merkel cell carcinoma. | journal = J Dermatol Sci | volume = 31 | issue = 3 | pages = 219-24 | month = May | year = 2003 | doi =  | PMID = 12727026 }}</ref>


===Others===
===Lymphoid===
*[[Follicular dendritic cell sarcoma]].
*[[Acute myeloid leukemia]].<ref name=nordiqc>URL: [http://www.nordiqc.org/Epitopes/CD56/CD56.htm http://www.nordiqc.org/Epitopes/CD56/CD56.htm]. Accessed on: September 13, 2014.</ref>
*[[Acute myeloid leukemia]].<ref name=nordiqc>URL: [http://www.nordiqc.org/Epitopes/CD56/CD56.htm http://www.nordiqc.org/Epitopes/CD56/CD56.htm]. Accessed on: September 13, 2014.</ref>
*[[Chronic myeloid leukemia]].<ref name=nordiqc/>
*[[Chronic myeloid leukemia]].<ref name=nordiqc/>
*[[Extranodal NK/T-cell lymphoma, nasal type]].
*[[Extranodal NK/T-cell lymphoma, nasal type]].
*[[Hepatosplenic T-cell lymphoma]].
*[[Plasma cell myeloma]]
===Others===
*[[Rhabdomyosarcoma]].<ref name=pmid18487991>{{Cite journal  | last1 = Bahrami | first1 = A. | last2 = Gown | first2 = AM. | last3 = Baird | first3 = GS. | last4 = Hicks | first4 = MJ. | last5 = Folpe | first5 = AL. | title = Aberrant expression of epithelial and neuroendocrine markers in alveolar rhabdomyosarcoma: a potentially serious diagnostic pitfall. | journal = Mod Pathol | volume = 21 | issue = 7 | pages = 795-806 | month = Jul | year = 2008 | doi = 10.1038/modpathol.2008.86 | PMID = 18487991 }}</ref>
*[[Solid pseudopapillary tumour‎]].
*[[Follicular dendritic cell sarcoma]].
==Occasionally positive==
*[[Renal cell carcinoma]] ~18% of cases.<ref name=pmid20462442>{{cite journal |authors=Ronkainen H, Soini Y, Vaarala MH, Kauppila S, Hirvikoski P |title=Evaluation of neuroendocrine markers in renal cell carcinoma |journal=Diagn Pathol |volume=5 |issue= |pages=28 |date=May 2010 |pmid=20462442 |pmc=2876076 |doi=10.1186/1746-1596-5-28 |url=}}</ref>


==See also==
==See also==

Latest revision as of 22:39, 26 March 2021

CD56 is a commonly available immunostain that is seen in a number of tumours. It is a sensitive marker of neuroendocrine differentiation.

Positive

Carcinomas

Lymphoid

Others

Occasionally positive

See also

References

  1. Kurokawa, M.; Nabeshima, K.; Akiyama, Y.; Maeda, S.; Nishida, T.; Nakayama, F.; Amano, M.; Ogata, K. et al. (May 2003). "CD56: a useful marker for diagnosing Merkel cell carcinoma.". J Dermatol Sci 31 (3): 219-24. PMID 12727026.
  2. 2.0 2.1 URL: http://www.nordiqc.org/Epitopes/CD56/CD56.htm. Accessed on: September 13, 2014.
  3. Bahrami, A.; Gown, AM.; Baird, GS.; Hicks, MJ.; Folpe, AL. (Jul 2008). "Aberrant expression of epithelial and neuroendocrine markers in alveolar rhabdomyosarcoma: a potentially serious diagnostic pitfall.". Mod Pathol 21 (7): 795-806. doi:10.1038/modpathol.2008.86. PMID 18487991.
  4. Ronkainen H, Soini Y, Vaarala MH, Kauppila S, Hirvikoski P (May 2010). "Evaluation of neuroendocrine markers in renal cell carcinoma". Diagn Pathol 5: 28. doi:10.1186/1746-1596-5-28. PMC 2876076. PMID 20462442. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2876076/.