Difference between revisions of "Medulloblastoma"

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Image: Cerebellar medulloblastoma (1) in adult.JPG | Medulloblastoma. (WC/KGH)
Image: Cerebellar medulloblastoma (1) in adult.JPG | Medulloblastoma. (WC/KGH)
Image: Cerebellar medulloblastoma (2) in adult.JPG | Medulloblastoma. (WC/KGH)
Image: Cerebellar medulloblastoma (2) in adult.JPG | Medulloblastoma. (WC/KGH)
File:Medulloblastoma with rosettes.jpg | Homer-Wright rosettes in a medulloblastoma. (WC/jensflorian)
File:Medulloblastoma stratum moleculare x40.jpg | Cerebellar infiltrative growth. (WC/jensflorian)
File:Desmoplastic nodular medulloblastoma.jpg | Demsomplastic nodular medullloblastoma. (WC/jensflorian)
File:Anaplastic medulloblastoma x200.jpg | Anaplastic large cell medulloblastoma. (WC/jensflorian)
File:AFIP405820M-MEDULLOBLASTOMA.jpg | Medulloblastoma cells smear. (AFIP)
File:Medulloblastoma .jpg | Medulloblastoma in the cerebellum. (AFIP)
</gallery>
</gallery>
Case:
<gallery>
File:Medulloblastoma_SHH_type_adult.jpg | Classic Medulloblastoma of the SHH type. (WC/jensflorian)
File:Medulloblastoma nuclear moulding HE stain.jpg | Epitheloid ribboning and nuclear moulding of tumor cells. (WC/jensflorian)
File:Medulloblastoma_geographic_necrosis.jpg | Areas of geographic necrosis. (WC/jensflorian)
File:Medulloblastoma_MAP2_IHC.jpg | Partial MAP2 immunoreactivity. (WC/jensflorian)
</gallery>
www:
www:
*[http://moon.ouhsc.edu/kfung/jty1/neurotest/Q93-Ans.htm Medulloblastoma (ouhsc.edu)].
*[http://moon.ouhsc.edu/kfung/jty1/neurotest/Q93-Ans.htm Medulloblastoma (ouhsc.edu)].

Revision as of 12:15, 19 June 2015

Medulloblastoma is a malignant small round cell tumour that is found in the cerebellum.

Morphologically identical supratentorial tumours are called primitive neuroectodermal tumour (PNET).

General

Gross

Microscopic

Features:[3]

DDx:

Images

Case:

www:

Subtypes

  • Classic medulloblastoma (~85% of all medulloblastomas).
  • Variants of medulloblastoma (~15% of all medulloblastomas together):
    1. Anaplastic variant.
    2. Large cell variant.
    3. Desmoplastic/nodular medulloblastoma (DNMB).
    4. Medulloblastoma with extensive nodularity (MBEN).

Notes:

  • Prognosis:[5][6] DNMB & MBEN > classic > anaplastic variant, large cell variant.

Anaplastic variant

Features:

  • Larger cells.
  • Severe anaplasia.
  • Polygonal cells.

See also

References

  1. Online 'Mendelian Inheritance in Man' (OMIM) 601309
  2. Lefkowitch, Jay H. (2006). Anatomic Pathology Board Review (1st ed.). Saunders. pp. 424 Q34. ISBN 978-1416025887.
  3. URL: http://moon.ouhsc.edu/kfung/jty1/neurotest/Q93-Ans.htm. Accessed on: 26 October 2010.
  4. Wippold FJ, Perry A (March 2006). "Neuropathology for the neuroradiologist: rosettes and pseudorosettes". AJNR Am J Neuroradiol 27 (3): 488–92. PMID 16551982.
  5. Gulino A, Arcella A, Giangaspero F (November 2008). "Pathological and molecular heterogeneity of medulloblastoma". Curr Opin Oncol 20 (6): 668–75. doi:10.1097/CCO.0b013e32831369f4. PMID 18841049.
  6. Rutkowski S, von Hoff K, Emser A, et al. (November 2010). "Survival and Prognostic Factors of Early Childhood Medulloblastoma: An International Meta-Analysis". J Clin Oncol 28 (33): 4961–4968. doi:10.1200/JCO.2010.30.2299. PMID 20940197.