Difference between revisions of "Giant cells"
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'''Giant cells''' are "big" cells with multiple nuclei. They come in different flavours, which are suggestive of causality. | [[Image:Giant cell in bronchial wash -- very high mag.jpg|thumb|right|Giant cell from a [[pulmonary cytopathology|bronchial wash]]. [[Pap stain]].]] | ||
'''Giant cells''' are "big" cells with multiple nuclei. They come in different flavours, which are suggestive of causality. | |||
This article deals with the classic types of giant cells. A more general differential diagnosis of giant cells is in ''[[giant cell lesions]]''. | |||
==Giant cell types== | ==Giant cell types== | ||
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|- | |- | ||
| Touton giant cell | | Touton giant cell | ||
| | | Nuclei form a ring around the cell periphery with eosinophilic cytoplasm centrally and foamy cytoplasm at the periphery. | ||
| [[ | | [[Juvenile xanthogranuloma]], [[xanthoma]], [[Erdheim-Chester disease]], [[fat necrosis]], [[dermatofibroma]] | ||
| | | High lipid content lesions<ref>URL: [http://granuloma.homestead.com/giant_cells.html http://granuloma.homestead.com/giant_cells.html]. Accessed on: 7 February 2011.</ref>, Named after Karl Touton | ||
| [[Image:Juvenile_xanthogranuloma_-_very_high_mag.jpg|thumb|200px|JXG (WC)]] | | [[Image:Juvenile_xanthogranuloma_-_very_high_mag.jpg|thumb|200px|JXG (WC)]] | ||
|- | |- | ||
| Line 25: | Line 28: | ||
| drug reaction, neoplasm, foreign body, infection, idiopathic, autoimmune, allergic | | drug reaction, neoplasm, foreign body, infection, idiopathic, autoimmune, allergic | ||
| [[granuloma|granulomatous inflammation]] | | [[granuloma|granulomatous inflammation]] | ||
| [[Image:Crohn%27s_disease_-_colon_-_very_high_mag.jpg|thumb|150px|Granuloma (WC)]] | | [[Image:Crohn%27s_disease_-_colon_-_very_high_mag.jpg|thumb|150px|center|Granuloma (WC)]] | ||
|- | |- | ||
| Langhans giant cell | | Langhans giant cell | ||
| peripheral eccentric nuclei<ref name=Ref_InstantPath7>{{Ref InstantPath|7}}</ref> | | peripheral semi-circular eccentric nuclei<ref name=Ref_InstantPath7>{{Ref InstantPath|7}}</ref> | ||
| | | tuberculosis, sarcoidosis. | ||
| '''not''' to be confused with ''Langerhans cells'' | | '''not''' to be confused with ''Langerhans cells'', Named after Theodor Langhans | ||
| [[Image:Granulation_tissue_containg_a_poorly_formed_granuloma_with_a_Langhan%27s_giant_cell.jpg|thumb|200px|LGC (WC)]] | | [[Image:Granulation_tissue_containg_a_poorly_formed_granuloma_with_a_Langhan%27s_giant_cell.jpg|thumb|200px|LGC (WC)]] | ||
|- | |- | ||
| Osteoclast-like giant cells | | Osteoclast-like giant cells | ||
| | | multiple bland central nuclei, ruffled cell membrane. | ||
| osteoclasts, others | | osteoclasts, others | ||
| [[AKA]] osteoclast-type giant cells | | [[AKA]] osteoclast-type giant cells | ||
Latest revision as of 09:18, 13 August 2018
File:Giant cell in bronchial wash -- very high mag.jpg
Giant cell from a bronchial wash. Pap stain.
Giant cells are "big" cells with multiple nuclei. They come in different flavours, which are suggestive of causality.
This article deals with the classic types of giant cells. A more general differential diagnosis of giant cells is in giant cell lesions.
Giant cell types
List:
- Touton giant cell.
- Osteoclast-like giant cell.
- Foreign body type giant cell.
Table
| Type | Histology | DDx | Other | Image |
| Touton giant cell | Nuclei form a ring around the cell periphery with eosinophilic cytoplasm centrally and foamy cytoplasm at the periphery. | Juvenile xanthogranuloma, xanthoma, Erdheim-Chester disease, fat necrosis, dermatofibroma | High lipid content lesions[1], Named after Karl Touton | Error creating thumbnail: JXG (WC) |
| Epithelioid type | scattered nuclei[2] | drug reaction, neoplasm, foreign body, infection, idiopathic, autoimmune, allergic | granulomatous inflammation | File:Crohn's disease - colon - very high mag.jpg Granuloma (WC) |
| Langhans giant cell | peripheral semi-circular eccentric nuclei[2] | tuberculosis, sarcoidosis. | not to be confused with Langerhans cells, Named after Theodor Langhans | Error creating thumbnail: LGC (WC) |
| Osteoclast-like giant cells | multiple bland central nuclei, ruffled cell membrane. | osteoclasts, others | AKA osteoclast-type giant cells |
See also
- Basics.
- Giant cell lesions - includes a DDx of lesions with giant cells.
- Histiocytoses.
References
- ↑ URL: http://granuloma.homestead.com/giant_cells.html. Accessed on: 7 February 2011.
- ↑ 2.0 2.1 Borley, Neil R.; Warren, Bryan F. (2007). Instant Pathology (1st ed.). Wiley-Blackwell. pp. 7. ISBN 978-1405132909.