AE1/AE3

AE1/AE3
Immunostain in short
AE1/AE3 staining in a small cell carcinoma. (WC/Yale Rosen)
Similar stains	Z622
Use	unknown primary, confirm carcinoma
Normal staining pattern	membranous
Positive	most carcinomas
Negative	most lymphomas, most sarcomas

AE1/AE3 is a common immunostain that marks keratins. It is considered a pankeratin by most.

Positive

• Most or all carcinomas.

Sarcomas:

• Chordoma.
• Desmoplastic small round cell tumour.
• Most epithelioid sarcomas.
• Others.

Negative

• Most lymphomas.
• Most sarcomas.
  • Biphenotypic sinonasal sarcoma.

See also

• CK7.
• CK20.
• EMA.
• Cytokeratin Z622.