Difference between revisions of "Plasma cell"
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[[Image:Plasmacell.jpg|thumb|right|A plasma cell.]] | |||
The '''plasma cell''' is white blood cell that produces antibodies. | The '''plasma cell''' is white blood cell that produces antibodies. | ||
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***Pale perinuclear crescentic - may be up to the size of the nucleus in active plasma cells. | ***Pale perinuclear crescentic - may be up to the size of the nucleus in active plasma cells. | ||
Images: | Note: | ||
*Multinucleation is not a worisome feature.{{fact}} | |||
===Images=== | |||
<gallery> | |||
Image: Multinucleated plasma cell -- high mag.jpg | Plasma cells - high mag. | |||
Image: Multinucleated plasma cell -- very high mag.jpg | Plasma cells - very high mag. | |||
Image: Multinucleated plasma cell -- extremely high mag.jpg | Plasma cells - extremely high mag. | |||
Image: Chronic_gastritis_--_very_high_mag.jpg | Plasma cells in [[chronic gastritis]] - very high mag. | |||
</gallery> | |||
<gallery> | |||
Image:Plasmacytoma_ultramini1.jpg | Plasma cells in a plasmacytoma. (WC) | |||
</gallery> | |||
==Neoplasia== | ==Neoplasia== | ||
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==IHC== | ==IHC== | ||
*CD38 +ve.<ref name=Ref_WMSP554>{{Ref WMSP|554}}</ref> | *CD38 +ve.<ref name=Ref_WMSP554>{{Ref WMSP|554}}</ref> | ||
*CD138 +ve.<ref name=Ref_WMSP554>{{Ref WMSP|554}}</ref> | *[[CD138]] +ve.<ref name=Ref_WMSP554>{{Ref WMSP|554}}</ref> | ||
Others: | Others: | ||
*CD19 -ve. | *CD19 -ve. | ||
*CD20 -ve | *CD20 -ve | ||
*CD56 -ve. | *[[CD56]] -ve. | ||
==Lesions where plasma cells are important== | |||
===Selected lesions with plasma cells=== | |||
Neoplasms: | |||
*[[Plasma cell neoplasms]]. | |||
*[[Lymphoplasmacytic lymphoma]] - '''not''' truly plasma cells. | |||
*[[Inflammatory myofibroblastic tumour]] (inflammatory pseudotumour). | |||
*Classical [[Hodgkin lymphoma]]. | |||
Inflammatory conditions: | |||
*[[Inflammatory bowel disease]] - esp. at crypt base. | |||
*[[Primary biliary cholangitis]]. | |||
*[[Chronic gastritis]]. | |||
*[[Plasma cell balanitis]] (Zoon balanitis). | |||
*[[Plasma cell vulvitis]] (Zoon vulvitis). | |||
*[[Plasma cell deciduitis]] (chronic deciduitis). | |||
Infectious: | |||
*[[Syphilis]]. | |||
*[[Chancroid]]. | |||
*[[Granuloma inguinale]]. | |||
*[[Lymphogranuloma venereum]]. | |||
===Plasma cells are absent=== | |||
*[[Common variable immunodeficiency]].<ref name=pmid20629103>{{cite journal |author=Agarwal S, Smereka P, Harpaz N, Cunningham-Rundles C, Mayer L |title=Characterization of immunologic defects in patients with common variable immunodeficiency (CVID) with intestinal disease |journal=Inflamm Bowel Dis |volume= |issue= |pages= |year=2010 |month=July |pmid=20629103 |doi=10.1002/ibd.21376 |url=}}</ref> | |||
==See also== | ==See also== | ||
*[[Basics]]. | |||
*[[Red blood cell]]. | *[[Red blood cell]]. | ||
*[[Neutrophil]]. | *[[Neutrophil]]. | ||
*[[Plasma cell neoplasms]]. | *[[Plasma cell neoplasms]]. | ||
*[[IgG4-related systemic disease]]. | |||
*[[Plasmacytoid urothelial carcinoma]]. | |||
==References== | ==References== | ||
Latest revision as of 21:02, 30 September 2021
The plasma cell is white blood cell that produces antibodies.
Microscopic
Features:
- Ovoid intermediate-small cell size ~ 12 micrometers:
- Cells slightly larger than red blood cells and neutrophils.
- Eccentric nucleus.
- Nucleus usu. hugs the cell membrane.
- "Clock-face" chromatin pattern.
- Small dots symmetrically rim the nuclear membrane - like the numbers on a clock.
- Abundant cytoplasm.
- Nucleus-to-cytoplasm ratio ~1:2
- Perinuclear hof (prominent Gogli apparatus).
- Pale perinuclear crescentic - may be up to the size of the nucleus in active plasma cells.
Note:
- Multinucleation is not a worisome feature.[citation needed]
Images
Plasma cells - high mag.
Plasma cells - very high mag.
Plasma cells - extremely high mag.
Plasma cells in chronic gastritis - very high mag.
Plasma cells in a plasmacytoma. (WC)
Neoplasia
Main article: Plasma cell neoplasms
Neoplasms derived from plasma cell are called plasma cell neoplasms.
IHC
Others:
- CD19 -ve.
- CD20 -ve
- CD56 -ve.
Lesions where plasma cells are important
Selected lesions with plasma cells
Neoplasms:
- Plasma cell neoplasms.
- Lymphoplasmacytic lymphoma - not truly plasma cells.
- Inflammatory myofibroblastic tumour (inflammatory pseudotumour).
- Classical Hodgkin lymphoma.
Inflammatory conditions:
- Inflammatory bowel disease - esp. at crypt base.
- Primary biliary cholangitis.
- Chronic gastritis.
- Plasma cell balanitis (Zoon balanitis).
- Plasma cell vulvitis (Zoon vulvitis).
- Plasma cell deciduitis (chronic deciduitis).
Infectious:
Plasma cells are absent
See also
- Basics.
- Red blood cell.
- Neutrophil.
- Plasma cell neoplasms.
- IgG4-related systemic disease.
- Plasmacytoid urothelial carcinoma.
References
- ↑ 1.0 1.1 Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 554. ISBN 978-0781765275.
- ↑ Agarwal S, Smereka P, Harpaz N, Cunningham-Rundles C, Mayer L (July 2010). "Characterization of immunologic defects in patients with common variable immunodeficiency (CVID) with intestinal disease". Inflamm Bowel Dis. doi:10.1002/ibd.21376. PMID 20629103.